3-HYDRAZINO-QUINOXALINE-2-THIOL
- Product Name
- 3-HYDRAZINO-QUINOXALINE-2-THIOL
- CAS No.
- 13080-21-2
- Chemical Name
- 3-HYDRAZINO-QUINOXALINE-2-THIOL
- Synonyms
- AKOS BBS-00008251;CHEMBRDG-BB 5215319;3-Hydrazinylquinoxaline-2-thiol;3-HYDRAZINO-QUINOXALINE-2-THIOL;3-Hydrazinylquinoxaline-2(1H)-thione;2(1H)-Quinoxalinethione, 3-hydrazinyl-;3-hydrazinoquinoxaline-2-thiol(SALTDATA: FREE);membranes,Helicobacter,ulcer,Antimicrobial,gastric,HPi1,inhibit,Inhibitor,Bacterial,permeate,HPi 1,HPi-1,orally,pylori,peptic
- CBNumber
- CB1135666
- Molecular Formula
- C8H8N4S
- Formula Weight
- 192.24
- MOL File
- 13080-21-2.mol
3-HYDRAZINO-QUINOXALINE-2-THIOL Property
- Melting point:
- 254 °C (decomp)(Solv: ethanol (64-17-5))
- Boiling point:
- 376.1±25.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- pka
- 7.91±0.20(Predicted)
- form
- Solid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H370Causes damage to organs
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H954603
- Product name
- 3-Hydrazinylquinoxaline-2-thiol
- Packaging
- 250mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- CS-0078290
- Product name
- HPi1
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- 6386CD
- Product name
- 3-Hydrazinoquinoxaline-2-thiol
- Packaging
- 500mg
- Price
- $386
- Updated
- 2021/12/16
- Product number
- CHM0984007
- Product name
- 3-HYDRAZINO-2-QUINOXALINETHIOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.43
- Updated
- 2021/12/16
- Product number
- BB-5215319
- Product name
- 3-hydrazinoquinoxaline-2-thiol
- Purity
- 95%
- Packaging
- 1g
- Price
- $235
- Updated
- 2021/12/16
3-HYDRAZINO-QUINOXALINE-2-THIOL Chemical Properties,Usage,Production
Biological Activity
HPi1 is a potent, selective and orally active antibacterial agent against Helicobacter pylori with IC50 of 0.24 μM and MIC of 0.08-0.16 μg/mL. It is inactive against other bacteria, including the enteric bacteria Lactobacillus casei, Lactobacillus reuteri and Bifidobacterium longum.
in vitro
The MIC against H. pylori isolates ranged from 0.002-0.032 μg/mL (0.01-0.17 μM) in the agar dilution assay. HPi1 is effective against the clarithromycin-resistant strains ARHp172 (MIC of 0.004–0.016 μg/mL) and ARHp246 (MIC of 0.008–0.032 μg/mL).
HPi1 has some activity against the Bacteroides species , but at concentrations at least 18- fold higher than the H. pylori MIC. More potent activity is detected for Campylobacter jejuni with an MIC of 0.3 μg/mL.
HPi1 has good physicochemical and pharmacological properties, including determining the aqueous solubility (19 μg/mL), human plasma protein binding (93% bound), stability with human liver microsomes (T 1/2 of 1.3 hours) and the ability to passively permeate membranes.
target
IC50: 0.24 μM ( Helicobacter pylori )
MIC: 0.08-0.16 μg/mL ( Helicobacter pylori )
3-HYDRAZINO-QUINOXALINE-2-THIOL Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDRAZINO-QUINOXALINE-2-THIOL Suppliers
- Tel
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- Fax
- --
- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6375
- Advantage
- 65
- Tel
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- Fax
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- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
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