conantokin R

Product Name: conantokin R
CAS No.: 202925-60-8
Chemical Name: conantokin R
Synonyms: conantokin R;PubChem ID: 90488802;L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-c...;L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-cysteinyl-L-tyrosyl-, cyclic (21→25)-disulfide
CBNumber: CB11367596
Molecular Formula: C127H201N35O49S3
Formula Weight: 3098.36
MOL File: 202925-60-8.mol

More

Less

conantokin R Property

Density: 1.56±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
Sequence: Gly-Glu-{Gla}-{Gla}-Val-Ala-Lys-Met-Ala-Ala-{Gla}-Leu-Ala-Arg-{Gla}-Asn-Ile-Ala-Lys-Gly-Cys-Lys-Val-Asn-Cys-Tyr-Pro (Disulfide bridge:Cys21-Cys25)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: PEP0004466
Product name: CONANTOKIN-R
Purity: 95.00%
Packaging: 5MG
Price: $495.45
Updated: 2021/12/16

More

Less

conantokin R Chemical Properties,Usage,Production

Description

Potent, non-competitive NMDA receptor antagonist (IC50= 93 nM) that has been suggested to have NR2 subunit selectivity. Inhibits inward currents evoked by NMDA in central nervous system neurons (IC50= 350 nM) and exhibits broad anticonvulsant and antiparkinsonian activityin vivoat doses devoid of behavioral toxicity.

Uses

Conantokin R (Con-R) is an NMDA receptor peptide antagonist with an IC50 of 93 nM. Conantokin R binds Zn2+ and Mg2+ with Kds of 0.15 μM and 6.5 μM, respectively. Conantokin R shows anticonvulsant activity[1][2].

References

[1] Blandl T, et al. Structure-function relationships of the NMDA receptor antagonist peptide, conantokin-R. FEBS Lett. 2000 Mar 24;470(2):139-46. DOI:10.1016/s0014-5793(00)01309-0
[2] White HS, et al. In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of the fish-hunting snail Conus radiatus. J Pharmacol Exp Ther. 2000 Jan;292(1):425-32. PMID:10604979

conantokin R Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

conantokin R Suppliers

China 5 United Kingdom 1 United States 3 USA 1 Global 10

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Creative Peptides

Tel
Email: info@creative-peptides.com
Country: United States
ProdList: 6083
Advantage: 56

BOC Sciences

Tel: 16314854226; +16314854226
Email: inquiry@bocsci.com
Country: United States
ProdList: 19654
Advantage: 58

Alomone Labs

Tel: 4008-168-068 13121892008
Email: info@alomone.com
Country: China
ProdList: 1241
Advantage: 58

Hangzhou ALLPEPTIDE Biotechnology Co., Ltd.

Tel: 17342063383
Email: sales@allpeptide.com
Country: China
ProdList: 5320
Advantage: 58

Fuan Bio

Tel: 18178976185
Email: 3855357086@qq.com
Country: China
ProdList: 2061
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Guangzhou Ruifeng Biotechnology Co., Ltd.

Tel: 14715141318
Country: CHINA
ProdList: 181
Advantage: 58

202925-60-8, conantokin RRelated Search:

conantokin R

PubChem ID: 90488802

L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-c...

L-Proline, glycyl-L-α-glutamyl-4-carboxy-L-α-glutamyl-4-carboxy-L-α-glutamyl-L-valyl-L-alanyl-L-lysyl-L-methionyl-L-alanyl-L-alanyl-4-carboxy-L-α-glutamyl-L-leucyl-L-alanyl-L-arginyl-4-carboxy-L-α-glutamyl-L-asparaginyl-L-isoleucyl-L-alanyl-L-lysylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-asparaginyl-L-cysteinyl-L-tyrosyl-, cyclic (21→25)-disulfide

202925-60-8

C127H201N35O49S3