ChemicalBook > CAS DataBase List > 6-chloro-2-methyl-4(1H)-quinazolinone

6-chloro-2-methyl-4(1H)-quinazolinone

Product Name
6-chloro-2-methyl-4(1H)-quinazolinone
CAS No.
7142-09-8
Chemical Name
6-chloro-2-methyl-4(1H)-quinazolinone
Synonyms
NSC 45786;6-chlro-2-Methylquinazolin-4-ol;6-chloro-2-methylquinazolin-4-ol;6-Chloro-2-methylquinazolin-4(3H);6-chloro-2-methylquinazolin-4(1H)-one;6-Chloro-2-Methyl-3H-quinazolin-4-one;6-chloro-2-methyl-4(1H)-quinazolinone;6-CHLORO-2-METHYLQUINAZOLIN-4(3H)-ONE;6-Chloro-4-hydroxy-2-methylquinazoline;4(3H)-Quinazolinone, 6-chloro-2-methyl-
CBNumber
CB11373470
Molecular Formula
C9H7ClN2O
Formula Weight
194.62
MOL File
7142-09-8.mol
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6-chloro-2-methyl-4(1H)-quinazolinone Property

Melting point:
287 °C
Boiling point:
355.1±44.0 °C(Predicted)
Density 
1.43
refractive index 
1.5330 (estimate)
storage temp. 
2-8°C
pka
1.84±0.20(Predicted)
Appearance
White to off-white Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S188131
Product name
6-CHLORO-2-METHYL-3H-QUINAZOLIN-4-ONE
Purity
Aldrich<sup>CPR</sup>
Packaging
1 unit
Price
$143
Updated
2025/07/31
Sigma-Aldrich
Product number
S188131
Product name
6-CHLORO-2-METHYL-3H-QUINAZOLIN-4-ONE
Purity
AldrichCPR
Packaging
5MG
Price
$139
Updated
2024/03/01
TRC
Product number
C424355
Product name
6-Chloro-4-hydroxy-2-methylquinazoline
Packaging
500mg
Price
$140
Updated
2021/12/16
TRC
Product number
C424355
Product name
6-Chloro-4-hydroxy-2-methylquinazoline
Packaging
100mg
Price
$55
Updated
2021/12/16
Apolloscientific
Product number
OR906046
Product name
6-Chloro-2-methylquinazolin-4(3H)-one
Purity
96%
Packaging
5g
Price
$537
Updated
2021/12/16
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6-chloro-2-methyl-4(1H)-quinazolinone Chemical Properties,Usage,Production

Uses

6-Chloro-4-hydroxy-2-methylquinazoline is a quinazolinone/quinazoline derivative.

Synthesis

21739-93-5

124-42-5

7142-09-8

A magnetic stirrer was charged into a two-necked round-bottomed flask, evacuated and displaced three times with nitrogen. An aqueous solution (3 mL) of 2 wt% TPGS-750-M in 2-bromo-5-chlorobenzoic acid (1, 0.5 mmol) and acetamidine hydrochloride (2, 0.75 mmol) was added under nitrogen protection. After stirring for 10 min, Cs2CO3 (1 mmol, 326 mg) was added to the flask. 15 min later, CuI (0.1 mmol, 19 mg) was added. The reaction mixture was stirred at the indicated temperature (see Table 3 in the text) for 12 h under nitrogen atmosphere. Upon completion of the reaction, the mixture was extracted with ethyl acetate (1 mL) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate (3:1 to 1:1) as eluent to afford 6-chloro-2-methylquinazolin-4-one.

References

[1] RSC Advances, 2014, vol. 4, # 91, p. 50285 - 50294
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 2, p. 348 - 351
[3] Tetrahedron, 2015, vol. 71, # 29, p. 4853 - 4858
[4] Applied Organometallic Chemistry, 2014, vol. 28, # 9, p. 661 - 665

6-chloro-2-methyl-4(1H)-quinazolinone Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-2-methyl-4(1H)-quinazolinone Suppliers

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7142-09-8, 6-chloro-2-methyl-4(1H)-quinazolinoneRelated Search:

6-chloro-2-methyl-4(1H)-quinazolinone 6-CHLORO-2-([(4-METHOXYPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-2-(2,4-DICHLOROPHENYL)-3-HYDROXY-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(4-CHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-2-(CHLOROMETHYL)-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(2,5-DICHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 2-[(BUTYLSULFANYL)METHYL]-6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 2-[(BENZYLSULFANYL)METHYL]-6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(3-CHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 2-([(4-BROMOPHENYL)SULFANYL]METHYL)-6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-2-(([3-(TRIFLUOROMETHYL)PHENYL]SULFANYL)METHYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-2-([(4-FLUOROPHENYL)SULFANYL]METHYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-HYDROXY-2-(4-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6-CHLORO-3-(2-METHYLPHENYL)-2-(([3-(TRIFLUOROMETHYL)PHENYL]SULFANYL)METHYL)-4(3H)-QUINAZOLINONE 6-CHLORO-2-([(2,6-DICHLOROPHENYL)SULFANYL]METHYL)-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 2-([(4-BROMOPHENYL)SULFANYL]METHYL)-6-CHLORO-3-(2-METHYLPHENYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-HYDROXY-2-(4-NITROPHENYL)-4(3H)-QUINAZOLINONE 6,8-DICHLORO-3-(2,6-DIMETHYLPHENYL)-2-([(4-METHOXYPHENYL)SULFANYL]METHYL)-4(3H)-QUINAZOLINONE

  • 6-chloro-2-methyl-4(1H)-quinazolinone
  • 6-Chloro-2-Methyl-3H-quinazolin-4-one
  • 6-chlro-2-Methylquinazolin-4-ol
  • 6-Chloro-4-hydroxy-2-methylquinazoline
  • 6-CHLORO-2-METHYLQUINAZOLIN-4(3H)-ONE
  • 6-chloro-2-methylquinazolin-4-ol
  • NSC 45786
  • 6-chloro-2-methylquinazolin-4(1H)-one
  • 6-Chloro-2-methylquinazolin-4(3H)
  • 6-chloro-2-methyl-3,4-dihydroquinazolin-4-one
  • 4(3H)-Quinazolinone, 6-chloro-2-methyl-
  • 7142-09-8
  • 7142-9-8