6-chloro-2-methyl-4(1H)-quinazolinone
- Product Name
- 6-chloro-2-methyl-4(1H)-quinazolinone
- CAS No.
- 7142-09-8
- Chemical Name
- 6-chloro-2-methyl-4(1H)-quinazolinone
- Synonyms
- NSC 45786;6-chlro-2-Methylquinazolin-4-ol;6-chloro-2-methylquinazolin-4-ol;6-Chloro-2-methylquinazolin-4(3H);6-chloro-2-methylquinazolin-4(1H)-one;6-Chloro-2-Methyl-3H-quinazolin-4-one;6-chloro-2-methyl-4(1H)-quinazolinone;6-CHLORO-2-METHYLQUINAZOLIN-4(3H)-ONE;6-Chloro-4-hydroxy-2-methylquinazoline;4(3H)-Quinazolinone, 6-chloro-2-methyl-
- CBNumber
- CB11373470
- Molecular Formula
- C9H7ClN2O
- Formula Weight
- 194.62
- MOL File
- 7142-09-8.mol
6-chloro-2-methyl-4(1H)-quinazolinone Property
- Melting point:
- 287 °C
- Boiling point:
- 355.1±44.0 °C(Predicted)
- Density
- 1.43
- refractive index
- 1.5330 (estimate)
- storage temp.
- 2-8°C
- pka
- 1.84±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S188131
- Product name
- 6-CHLORO-2-METHYL-3H-QUINAZOLIN-4-ONE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1 unit
- Price
- $143
- Updated
- 2025/07/31
- Product number
- S188131
- Product name
- 6-CHLORO-2-METHYL-3H-QUINAZOLIN-4-ONE
- Purity
- AldrichCPR
- Packaging
- 5MG
- Price
- $139
- Updated
- 2024/03/01
- Product number
- C424355
- Product name
- 6-Chloro-4-hydroxy-2-methylquinazoline
- Packaging
- 500mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- C424355
- Product name
- 6-Chloro-4-hydroxy-2-methylquinazoline
- Packaging
- 100mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- OR906046
- Product name
- 6-Chloro-2-methylquinazolin-4(3H)-one
- Purity
- 96%
- Packaging
- 5g
- Price
- $537
- Updated
- 2021/12/16
6-chloro-2-methyl-4(1H)-quinazolinone Chemical Properties,Usage,Production
Uses
6-Chloro-4-hydroxy-2-methylquinazoline is a quinazolinone/quinazoline derivative.
Synthesis
21739-93-5
124-42-5
7142-09-8
A magnetic stirrer was charged into a two-necked round-bottomed flask, evacuated and displaced three times with nitrogen. An aqueous solution (3 mL) of 2 wt% TPGS-750-M in 2-bromo-5-chlorobenzoic acid (1, 0.5 mmol) and acetamidine hydrochloride (2, 0.75 mmol) was added under nitrogen protection. After stirring for 10 min, Cs2CO3 (1 mmol, 326 mg) was added to the flask. 15 min later, CuI (0.1 mmol, 19 mg) was added. The reaction mixture was stirred at the indicated temperature (see Table 3 in the text) for 12 h under nitrogen atmosphere. Upon completion of the reaction, the mixture was extracted with ethyl acetate (1 mL) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate (3:1 to 1:1) as eluent to afford 6-chloro-2-methylquinazolin-4-one.
References
[1] RSC Advances, 2014, vol. 4, # 91, p. 50285 - 50294
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 2, p. 348 - 351
[3] Tetrahedron, 2015, vol. 71, # 29, p. 4853 - 4858
[4] Applied Organometallic Chemistry, 2014, vol. 28, # 9, p. 661 - 665
6-chloro-2-methyl-4(1H)-quinazolinone Preparation Products And Raw materials
Raw materials
Preparation Products
6-chloro-2-methyl-4(1H)-quinazolinone Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58