HBTU

Product Name: HBTU
CAS No.: 94790-37-1
Chemical Name: HBTU
Synonyms: 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide;O-benzotriazol-l-yl-tetramethyluroniumhexafluorophosphate;O-BENZOTRIAZOL-1-YL-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE;HBTU;-1-yL;HBTU,99%;HBTU 25 G
CBNumber: CB1138465
Molecular Formula: C11H16F6N5OP
Formula Weight: 379.25
MOL File: 94790-37-1.mol

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HBTU Property

Melting point:: 200 °C (dec.)(lit.)
Flash point:: 200°C
storage temp.: Store at +2°C to +8°C.
solubility: acetonitrile: 0.1 g/mL, clear
form: Powder
color: White to Off-White
PH: 4.1 (1.6g/l, H2O)
Decomposition: 200 ºC
BRN: 7328329
Stability:: Stable. Incompatible with oxidizing agents.
InChI: InChI=1S/C11H16N5O.F6P/c1-13(2)11(14(3)4)15-9-7-5-6-8-10(9)16(17)12-15;1-7(2,3,4,5)6/h5-8H,1-4H3;/q+1;-1
InChIKey: UQYZFNUUOSSNKT-UHFFFAOYSA-N
SMILES: [P+5]([F-])([F-])([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=CC=CC=C/12)(\N(C)C)/N(C)C
CAS DataBase Reference: 94790-37-1(CAS DataBase Reference)
EPA Substance Registry System: 1H-Benzotriazolium, 1-[bis(dimethylamino)methylene]-, 3-oxide, hexafluorophosphate(1-) (1:1) (94790-37-1)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22-42/43
Safety Statements: 26-36/37/39-36-22
WGK Germany: 3
F: 8-10-21
Hazard Note: Irritant
HS Code: 29339980
Toxicity: LD50 orally in Rabbit: > 2000 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.51006
Product name: HBTU
Purity: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem?
Packaging: 25g
Price: $72.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.51006
Product name: HBTU
Purity: 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate Novabiochem?
Packaging: 100g
Price: $217
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12804
Product name: HBTU
Purity: ≥98.0% (T)
Packaging: 1g
Price: $52.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12804
Product name: HBTU
Purity: ≥98.0% (T)
Packaging: 5G
Price: $103
Updated: 2024/03/01

Sigma-Aldrich

Product number: 12804
Product name: HBTU
Purity: ≥98.0% (T)
Packaging: 25g
Price: $328
Updated: 2024/03/01

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HBTU Chemical Properties,Usage,Production

Chemical Properties

white to light yellow powder

Uses

HBTU is a coupling reagent used in peptide synthesis. HBTU has been shown to effectively suppress racemization.

Biological Activity

hbtu (2-(1h-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexauorophosphate), a coupling reagent commonly used in solid phase peptide synthesis. after being introduced in 1978, this agent shows popularity in chemistry and industry use due to its mild activating properties. moreover, it also shows resistance against racemization. low tendency for racemization is a key requirement for peptide synthesis. especially for solid phase peptide synthesis, quantitative yields with short reaction times are crucial in order to make the synthesis of large peptides feasible. [1]

Synthesis

HBTU is synthesized by reaction of HOBt with TCFH under basic conditions.

in vitro

peptide synthesis relied mostly on efficient and safe coupling reagents. hbtu was proved to transform carboxylic acids into azides efficiently and practically. the process might be applied to a wide range of carboxylic acids including n-protected amino acids. in addition, hbtu was of great value in one-pot synthesis of dipeptidyl urea esters, ureas, and carbamates from acids. the advantages of hbtu included the following points: 1) non-explosive and therefore more suitable for solution/solid phase peptide synthesis. 2) high solubility and stability in classical solvents. 3) feasible for colorimetric reaction monitoring. [2]

Purification Methods

Wash the salt with H2O (3x), CH2Cl2 (3x), dry and recrystallise it from MeCN. Dry it in a vacuum and store it cold in the dark [Dourtoglou et al. Tetrahedron Lett 1269 1978, NMR: Dourtoglou and Gross Synthesis 572 1984]. Benzoxazolinone (2 -hydroxybenzoxazole) [59 -49 -4] M 135.1, m 137 -139o, 142 -143o(corrected), b 121-213o/17mm, 335-337o/760mm. Benzoxazolinone is purified by recrystallisation from aqueous Me2CO followed by distillation at atmospheric pressure, then in a vacuum. The methyl mercury salt recrystallises from aqueous EtOH and has m 156-158o. [Bywater et al. J Am Chem Soc 67 905 1945, Beilstein 27 III/IV 2677.]

References

[1]adam s. hbtu: a mild activating ageiw of muramic acid. bioorg med chem lett. 1992 mar; 2(6): 571-4.
[2]knorr r, trzeciak a, bannwarth w and gillessen d. new coupling reagents in peptide chemistry. tetrahedron lett. 1989; 30(15): 1927-30.

HBTU Preparation Products And Raw materials

Raw materials

Preparation Products

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HBTU Suppliers

Americas 1 Canada 5 China 443 Europe 5 France 3 Germany 7 India 26 Israel 2 Japan 8 Slovakia 1 Switzerland 3 United Kingdom 17 United States 62 Global 583

BTC pharm India

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TCI Chemicals (India) Pvt. Ltd.

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Sisco Research Laboratories Pvt. Ltd.

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Alfa Aesar

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Bblocks Chemicals Llp

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LOBA CHEMIE PVT.LTD.

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Central Drug House(P) Ltd.

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A.J Chemicals

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CHEMSWORTH

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View Lastest Price from HBTU manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Hbtu 94790-37-1
Price: US $75.00-20.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-29

airuikechemical co., ltd.

Product: hbtu 94790-37-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-08

Hangzhou ICH Biofarm Co., Ltd

Product: HBTU 94790-37-1
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 2000kg
Release date: 2023-06-09

94790-37-1, HBTURelated Search:

2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate HOAt 1-Hydroxybenzotriazole HATU Hexafluorophosphoric acid Potassium hexafluorophosphate 5-Methyl-1H-benzotriazole Tolyltriazole Lithium hexafluorophosphate Sodium hexafluorophosphate 1H-Benzotriazole 2-(7-Azabenzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one 1-Hydroxybenzotriazole hydrate Ammonium hexafluorophosphate 5-Chloro-1-[bis(dimethylamino)methylene]-1H-benzotriazolium 3-oxide hexafluorophosphate (Benzotriazol-1-yloxy)dipyrrolidinocarbenium hexafluorophosphate HBTU

O-(1H-BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

O-(BENZOTRIAZOL-1-YL)-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

O-(BENZOTRIAZOL-1-YL)-N-N-N ,N -TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE POLYMER BOUND

O-BENZOTRIAZOL-1-YL-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

O-BENZOTRIAZOLE-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM

O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM-HEXAFLUORO-PHOSPHATE

O-BENZOTRIAZOLE-N,N,N',N'-TETRAMTHYL-URONIUM-HEXAFLUORO-PHOSPHATE

N-[(1-H-BENZOTRIAZOL-1-YL)(DIMETHYLAMINO)METHYLENE]-N-METHYLMETHANAMINIUM HEXAFLUOROPHOSPHATE N-OXIDE

O-(1H-benzotriazol-1-y1)-N,N,N'N'-tetramethyluronium Hexafluorophosphate(HBTU)

O-BENZOTRIAZOL-1-YL-TETRAMETHYLURONIUM (HBTU )

HBTU (O-(BENZOTRIAZOL-1-YL)-N,N,N'',N''-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE)

O-(Benzotriazole-N,N,N'',N''-tetramethyluronium hexafluorophosphate (HBTU)

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium Hexafluorophosphate [Coupling Reagent for Peptide]

benzotriazolyl tetramethyluronium fluorophosphate

HBTU, N,N,Nμ,Nμ-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate

(Benzotriazol-1-yloxy-dimethylaminomethylidene)-dimethylazanium hexafluorophosphate

O-Benzotriazolyl-N,N,N',N'-tetramethyluronium hexafluorophosphate

o-Benzotriazole-N,N,N',N'-tetramethyl-uronium-hexafluorophosphate ,99%

HBTU (o-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexaflu

HBTU,2 bottles kit, 0.1M in HOBT/DMF (0.5M HOBT in DMF)

HBTU,99%

1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate≥ 99% (HPLC)

O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate

HBTU [Coupling Reagent for Peptide]

O-BENZOTRIAZOL-1-YL-N,N,N',N'-TETR

O-benzotriazol-1-yl-tetramethyluronium hexafluorophosphate (HBTU)

O-（1H-Benzotriazole-1-yl）-N,N,N,N-tetramethyluronium Hexafluorophosphate

1-Hydroxy Benzotriazole (HBTU)

[(1H-1,2,3-benzotriazol-1-yloxy)(dimethylamino)methylidene]dimethylazanium

1-(bis(dimethylamino)methylene)-1H-benzo[d][1,2,3]triazole-1-ium 3-oxide hexafluorophosphate(V)

BENZOTRIAZOL-1-YL-N,N,N',N'-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

HBTU

HBTU POLYMER BOUND

HBTU-REAGENT

HEXAFLUOROPHOSPHATE HBTU

2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONOIUM HEXAFLUORPHOSPHATE

2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE

1-[BIS(DIMETHYLAMINO)METHYLENE]-1H-BENZOTRIAZOLIUM 3-OXIDE HEXAFLUOROPHOSPHATE

O-(1H-Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexaflorophosphate

HBTU [O-BENZOTRIAZOLE-N,N,N',N'-TETRAMETHYL-URONIUM-HEXAFLUORO-PHOSPHATE]

O-Benzotriazol-1-yl-tetramethyluronium

2-(1H-BENZOTRIAZOLE-1-YL)-1,1,3,3-TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE (HBTU)

HBTU, 3 bottles, 0.1M in HOBT/DMF (0.45M HOBT in DMF)1:1

1H-Benzotriazolium, 1-bis(dimethylamino)methylene-, hexafluorophosphate(1-), 3-oxide

2-(1H-BENZOTRIAZOL-1-YL)-1,1,3,3-TETRAMETHYLURONIUMHEXAFLUOROPHOSPHATE(HBTU)

ORTHOBENZOTRIAZOLE1YLNNNNTETRAMETHYLURONIUMHEXAFLUOROPHOSPHATE

HBTU [O-Benzotriazole-N

N'-tetraMethyl-uroniuM-hexafluoro-phosphate]

HBTU (o-(Benzotriazol-1-yl)-N,N,Nzzhlxy,Nzzhlxy-tetramethyluronium hexafluorophosphate)

HBTU 2-(1H-Benzotriazole-1-yl)-1,1,3,3-tetraMethyluroniuM hexafluorophosphate

O-(Benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate,N,N,N′,N′-Tetramethyl-O-(1H-benzotriazol-1-yl)uronium hexafluorophosphate, HBTU

O-Benzotriazole-N,N

HBTU N,N,N',N'-Tetramethyl-O-(benzotriazol-1-yl)uronium Hexafluorophosphate

N,N,N',N'-TETRAMETHYL-O-(1H-BENZOTRIAZOL-1-YL)URONIUM HEXAFLUOROPHOSPHATE