elaiophylin
- Product Name
- elaiophylin
- CAS No.
- 37318-06-2
- Chemical Name
- elaiophylin
- Synonyms
- EfoMycin E;Salbomycin;Elaiophilin;elaiophylin;GopalaMicin;EfoMycine E;Azalomycin B;Olive leaf hormone;Elaiophylin (>85%);Elaiophylin (Azalomycin B)
- CBNumber
- CB11393845
- Molecular Formula
- C54H88O18
- Formula Weight
- 1025.27
- MOL File
- 37318-06-2.mol
elaiophylin Property
- Melting point:
- 179-182℃
- Boiling point:
- 1080.5±65.0 °C(Predicted)
- Density
- 1.25
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 12.18±0.70(Predicted)
- form
- White to off-white solid.
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15583
- Product name
- Elaiophylin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 15583
- Product name
- Elaiophylin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $326
- Updated
- 2024/03/01
- Product number
- 207162
- Product name
- Elaiophylin
- Packaging
- 1mg
- Price
- $325
- Updated
- 2021/12/16
- Product number
- E501003
- Product name
- Elaiophylin
- Packaging
- 2.5mg
- Price
- $525
- Updated
- 2021/12/16
- Product number
- BVT-0185-M001
- Product name
- Elaiophylin
- Purity
- ≥95%(HPLC)
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
elaiophylin Chemical Properties,Usage,Production
Uses
Elaiophyllin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelminthic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumour cells.
Uses
Elaiophylin is a highly characteristic metabolite produced by Streptomyces hygroscopicus. Elaiophylin inhibits testosterone 5-reductase. Elaiophylin is synergistic with its co-metabolite, rapamycin, as an antifungal. Elaiophylin also has anthelmintic and immunosuppressive activity and inhibits NO synthesis. Elaiophylin displays broad, albeit weak, biological activity against bacteria, nematodes, protozoa and mammalian tumor cells.
Uses
Elaiophylin is a macrodiolide antibiotic that can be isolated from various strains of Streptomyces. It displays in vitro anti-protozoal activity against both Plasmodium and Trypanosoma (IC50s = 370 and 460 ng/ml, respectively) and cytotoxicity against human fetal lung fibroblast MRC-5 cells (IC50 = 870 ng/ml). Elaiophylin alone has no activity against Candida, although it enhances the anti-fungal activity of rapamycin . Elaiophylin also forms stable, long-lasting ion channels in bilayer membranes that are selective for cations.
Definition
ChEBI: A macrolide that is isolated from several bacteria including Streptomyces violaceoniger and other soil actinomycetes.
in vivo
Treatment with 2 mg/kg Elaiophylin (given i.p. every 2 days for 21 days; in BALB/C athymic mice) significantly suppresses ovarian cancer SKOV3 cells growth compared with DMSO treatment, resulting in a 72% decrease in the average daily tumor growth rate compared with DMSO treatment [1].
Lower doses of Elaiophylin as a single agent exert significant antitumor activity, while higher doses lead to intestinal toxicity. Administration of a lower dose (2 mg/kg) of Elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis. Toxic reactions are observed only in the 8 mg/kg group[1].
| Animal Model: | 4-wk-old BALB/C athymic mice with ovarian cancer SKOV3 cells[1] |
| Dosage: | 1 or 2 mg/kg |
| Administration: | Given i.p. every 2 days for 21 days |
| Result: | Treatment with 2 mg/kg significantly suppressed ovarian cancer SKOV3 cells growth compared with DMSO treatment. |
elaiophylin Preparation Products And Raw materials
Raw materials
Preparation Products
elaiophylin Suppliers
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 12952
- Advantage
- 65
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2782
- Advantage
- 58
- Tel
- 028-81700200 18116577057
- Fax
- 028-81705658
- 3003855609@qq.com
- Country
- China
- ProdList
- 7777
- Advantage
- 56
- Tel
- 027-59599241 18871490274
- Fax
- 027-59599241
- 1400878000@qq.com
- Country
- China
- ProdList
- 9541
- Advantage
- 58
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4827
- Advantage
- 55
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 6687
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 86249
- Advantage
- 60