2-AMINO-BENZOTHIAZOL-6-OL

Product Name: 2-AMINO-BENZOTHIAZOL-6-OL
CAS No.: 26278-79-5
Chemical Name: 2-AMINO-BENZOTHIAZOL-6-OL
Synonyms: ASISCHEM X25426;VITAS-BB TBB000062;TIMTEC-BB SBB010476;2-Amino-6-benzothiazolol;2-AMINO-BENZOTHIAZOL-6-OL;2-AMINO-BENZOTHIAZOLE-6-OL;6-Benzothiazolol, 2-amino-;2-AMINOBENZO[D]THIAZOL-6-OL;6-Hydroxybenzothiazol-2-amine;2-AMINO-1,3-BENZOTHIAZOL-6-OL
CBNumber: CB1139543
Molecular Formula: C7H6N2OS
Formula Weight: 166.2
MOL File: 26278-79-5.mol

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2-AMINO-BENZOTHIAZOL-6-OL Property

Melting point:: 243-250℃
Boiling point:: 394.6±34.0 °C(Predicted)
Density: 1.553±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 8.69±0.40(Predicted)
form: solid
Appearance: Off-white to gray Solid
InChI: InChI=1S/C7H6N2OS/c8-7-9-5-2-1-4(10)3-6(5)11-7/h1-3,10H,(H2,8,9)
InChIKey: VLNVTNUTGNBNBY-UHFFFAOYSA-N
SMILES: S1C2=CC(O)=CC=C2N=C1N
CAS DataBase Reference: 26278-79-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-36-20/21/22-22
Safety Statements: 26-36/37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 750786
Product name: 2-Amino-6-hydroxybenzothiazole
Purity: 95%
Packaging: 1g
Price: $29
Updated: 2025/07/31

Sigma-Aldrich

Product number: CDS007524
Product name: 2-amino-benzothiazol-6-ol
Purity: AldrichCPR
Packaging: 1g
Price: $104
Updated: 2024/03/01

TRC

Product number: A634688
Product name: 2-Amino-6-hydroxybenzothiazole
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A634688
Product name: 2-Amino-6-hydroxybenzothiazole
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Oakwood

Product number: 015339
Product name: 2-Amino-benzothiazol-6-ol
Packaging: 250mg
Price: $12
Updated: 2021/12/16

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2-AMINO-BENZOTHIAZOL-6-OL Chemical Properties,Usage,Production

Uses

2-Amino-6-hydroxybenzothiazole is a reagent used in the chemical synthesis of new benzothiazole derivatives with anti proliferative and antiiconvulsant activity.

Synthesis Reference(s)

The Journal of Organic Chemistry, 35, p. 4103, 1970 DOI: 10.1021/jo00837a003

Synthesis

1520-27-0

26278-79-5

General procedure for the synthesis of 2-amino-6-hydroxybenzothiazole from 1-(4-hydroxyphenyl)thiourea: 1-(4-hydroxyphenyl)thiourea (5 g, 29.7 mmol) was dissolved in chloroform (30 mL) in a 100 mL two-necked round-bottomed flask fitted with a stirrer. The chloroform (15 mL) solution of bromine (5 g, 29.7 mmol) was transferred to a dropping funnel and slowly added dropwise to the reaction mixture under stirring while controlling the reaction temperature to be lower than 5 °C. After the dropwise addition, the reaction was continued with stirring for 4-6 hours. Subsequently, the reaction mixture was refluxed on a water bath until no more hydrogen bromide gas escaped. After completion of the reaction, the resulting solid was treated with ice water and filtered. The filtrate was neutralized with ammonia solution and the precipitated white precipitate was filtered and washed with water. Finally, the product 2-amino-6-hydroxybenzothiazole was recrystallized from ethanol to give a white solid powder (4 g, 80% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz): δ 9.10 (s, 1H, -OH), 7.13 (d, J = 8.4 Hz, 1H, ArH, C5-H), 7.06 (s, 2H, -NH2), 7.01 (d, J = 2.4 Hz, 1H, ArH, C4-H), 6.65 (dd, J = 2.6 , 8.6 Hz, 1H, ArH, C7-H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3460 - 3463
[2] Medicinal Chemistry Research, 2012, vol. 21, # 7, p. 1136 - 1148
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 21, p. 9814 - 9824

2-AMINO-BENZOTHIAZOL-6-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-BENZOTHIAZOL-6-OL Suppliers

Canada 1 China 122 Europe 1 France 1 Germany 4 India 3 Russia 3 Ukraine 1 United Kingdom 7 United States 20 Global 163

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View Lastest Price from 2-AMINO-BENZOTHIAZOL-6-OL manufacturers

Career Henan Chemica Co

Product: 2-AMINO-BENZOTHIAZOL-6-OL 26278-79-5
Price: US $0.37/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/100kg
Release date: 2020-11-09

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-AMINO-BENZOTHIAZOL-6-OL 26278-79-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

26278-79-5, 2-AMINO-BENZOTHIAZOL-6-OLRelated Search:

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26278-79-5

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