TNP 351

Product Name: TNP 351
CAS No.: 125991-51-7
Chemical Name: TNP 351
Synonyms: TNP 351;N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-
CBNumber: CB11399317
Molecular Formula: C21H24N6O5
Formula Weight: 440.45
MOL File: 125991-51-7.mol

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Hazard and Precautionary Statements (GHS)

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TNP 351 Chemical Properties,Usage,Production

Uses

TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].

References

[1] F Itoh ,et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34(4):273-9. DOI:10.1007/BF00686032

TNP 351 Preparation Products And Raw materials

Raw materials

Preparation Products

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TNP 351 Suppliers

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125991-51-7, TNP 351Related Search:

CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071517 4-N-BUTYLBENZYLAMINE TNP 351 4-N-BUTYLBENZAMIDE 5-METHYL-7H-PYRROLO[2,3-D]PYRIMIDINE-2,4-DIAMINE 4-Amino-7H-pyrrolo[2,3-d]pyrimidine CHEMBRDG-BB 9071469

TNP 351

N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid

L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-

125991-51-7