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1-Boc-(4-benzyl)piperazine

Product Name
1-Boc-(4-benzyl)piperazine
CAS No.
57260-70-5
Chemical Name
1-Boc-(4-benzyl)piperazine
Synonyms
BUTTPARK 146\06-23;1-Boc-4-Benzylpiperazine;4-BENZYL-1-BOC-PIPERAZINE;1-BENZYL-4-BOC-PIPERAZINE;1-N-Boc-4-benzylpiperazine;4-BENZYL-1-T-BUTOXYCARBONYLPIPERAZINE;1-Benzyl-4-(tert-butoxycarbonyl)piperazine;TERT-BUTYL 4-BENZYL-1-PIPERAZINECARBOXYLATE;TERT-BUTYL 4-BENZYLPIPERAZINE-1-CARBOXYLATE;4-BENZYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
CBNumber
CB1139932
Molecular Formula
C16H24N2O2
Formula Weight
276.37
MOL File
57260-70-5.mol
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1-Boc-(4-benzyl)piperazine Property

Melting point:
71-73 °C(lit.)
Boiling point:
362.5±35.0 °C(Predicted)
Density 
1.087±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
6.50±0.10(Predicted)
Appearance
Off-white to light yellow Solid
BRN 
797033
CAS DataBase Reference
57260-70-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39
WGK Germany 
3
HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
374830
Product name
1-Boc-(4-benzyl)piperazine
Purity
98%
Packaging
1g
Price
$81.22
Updated
2025/07/31
TRC
Product number
B585330
Product name
tert-Butyl4-Benzylpiperazine-1-carboxylate
Packaging
500mg
Price
$110
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006571
Product name
1-BENZYL-4-BOC-PIPERAZINE
Purity
95.00%
Packaging
1G
Price
$654.89
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0006571
Product name
1-BENZYL-4-BOC-PIPERAZINE
Purity
95.00%
Packaging
5G
Price
$933.82
Updated
2021/12/16
AK Scientific
Product number
8409AB
Product name
tert-Butyl4-benzylpiperazine-1-carboxylate
Packaging
100g
Price
$1011
Updated
2021/12/16
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1-Boc-(4-benzyl)piperazine Chemical Properties,Usage,Production

General Description

1-Boc-(4-benzyl)piperazine is an heterocyclic building block.

Synthesis

100-39-0

57260-71-6

57260-70-5

To a stirred solution of N-BOC-piperazine (6.0 g, 33.0 mmol, 1.0 eq.) in acetonitrile (60 mL), the reaction mixture was cooled to 0°C. Subsequently, triethylamine (22 mL, 161 mmol, 5.0 eq.) and benzyl bromide (6.0 mL, 35.0 mmol, 1.1 eq.) were added slowly and dropwise. The reaction mixture was stirred continuously for about 6 hours at room temperature. After completion of the reaction, the mixture was diluted with water and extracted with dichloromethane (CH2Cl2). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to afford the target product 1-benzyl-4-Boc-piperazine (6.5 g, 76.0% yield) as a white solid.

References

[1] Synthetic Communications, 2009, vol. 39, # 13, p. 2297 - 2303
[2] Patent: WO2017/17630, 2017, A1. Location in patent: Page/Page column 34-35
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 4, p. 1830 - 1842
[4] Patent: WO2017/58716, 2017, A1. Location in patent: Paragraph 00268
[5] Journal of Heterocyclic Chemistry, 2010, vol. 47, # 1, p. 54 - 62

1-Boc-(4-benzyl)piperazine Preparation Products And Raw materials

Raw materials

Benzyl chloride Ethanol Sodium sulfate Sodium thiosulfate Di-tert-butyl dicarbonate Potassium carbonate Piperazine Diethyl ether Iodine Ethyl acetate Sodium bicarbonate Dichloromethane Methanol Sodium hydroxide 1-Benzylpiperazine PETROLEUM ETHER

Preparation Products

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1-Boc-(4-benzyl)piperazine Suppliers

China 98 Germany 2 India 4 Switzerland 2 The Netherlands 1 United Kingdom 7 United States 18 Global 132
Biosynth AG
Tel
--
Fax
--
Email
welcome@biosynth.ch
Country
Switzerland
ProdList
3324
Advantage
72
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 1-Boc-(4-benzyl)piperazine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
1-Boc-(4-benzyl)piperazine 57260-70-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
1-Boc-(4-benzyl)piperazine 57260-70-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10
Career Henan Chemical Co
Product
1-Boc-(4-benzyl)piperazine 57260-70-5
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-10

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