tribendimidine

Product Name: tribendimidine
CAS No.: 115103-15-6
Chemical Name: tribendimidine
Synonyms: tribendimidine;Tribendimidine, 10 mM in DMSO;Ethanimidamide, N',N'''-[1,4-phenylenebis(methylidynenitrilo-4,1-phenylene)]bis[N,N-dimethyl-;N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide);N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide);N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide;N'-(4-{[(4-{[(4-{[1-(dimethylamino)ethylidene]amino}phenyl)imino]methyl}phenyl)methylidene]amino}phenyl)-N,N-dimethylethanimidamide
CBNumber: CB11400967
Molecular Formula: C28H32N6
Formula Weight: 452.59
MOL File: 115103-15-6.mol

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tribendimidine Property

Boiling point:: 618.2±65.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
form: Solid
pka: 12.31±0.15(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3
InChIKey: XOIOGKHKNQYULW-UHFFFAOYSA-N
SMILES: C1(C=NC2=CC=C(N=C(N(C)C)C)C=C2)=CC=C(C=NC2=CC=C(N=C(N(C)C)C)C=C2)C=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0025428
Product name: TRIBENDIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.69
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 5mg
Price: $45
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 10mg
Price: $75
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 100mg
Price: $295
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 250mg
Price: $425
Updated: 2021/12/16

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tribendimidine Chemical Properties,Usage,Production

Uses

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist[1][2][3].

in vivo

Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters^[2].

Animal Model:	C. sinensis infected Female Wistar rats^[2]
Dosage:	75 mg/kg and 150 mg/kg
Administration:	Oral administration, once
Result:	A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.

References

[1] Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14. DOI:10.1016/j.actatropica.2005.01.013
[2] Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8. DOI:10.1128/AAC.01366-06
[3] Hu Y, et al. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. DOI:10.1371/journal.pntd.0000499

tribendimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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tribendimidine Suppliers

China 49 South Korea 1 United States 1 Global 51

Shandong Xinhua Pharmaceutical Co.,Ltd.

Tel: +86-533-2196810
Fax: +86-533-2282825
Country: China
ProdList: 168
Advantage: 63

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4817
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 4963
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: 021-58958618
Email: sales@uhnshanghai.com
Country: China
ProdList: 1984
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
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Country: China
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Baoji Guokang Healthchem co.,ltd

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Country: CHINA
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AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15079
Advantage: 58

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View Lastest Price from tribendimidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: tribendimidine 115103-15-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

115103-15-6, tribendimidineRelated Search:

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tribendimidine

Ethanimidamide, N',N'''-[1,4-phenylenebis(methylidynenitrilo-4,1-phenylene)]bis[N,N-dimethyl-

N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide

N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)

N'-(4-{[(4-{[(4-{[1-(dimethylamino)ethylidene]amino}phenyl)imino]methyl}phenyl)methylidene]amino}phenyl)-N,N-dimethylethanimidamide

Tribendimidine, 10 mM in DMSO

N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)

115103-15-6

C28H32N6