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tribendimidine

Product Name: tribendimidine
CAS No.: 115103-15-6
Chemical Name: tribendimidine
Synonyms: tribendimidine;Tribendimidine, 10 mM in DMSO;Ethanimidamide, N',N'''-[1,4-phenylenebis(methylidynenitrilo-4,1-phenylene)]bis[N,N-dimethyl-;N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide);N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide);N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide;N'-(4-{[(4-{[(4-{[1-(dimethylamino)ethylidene]amino}phenyl)imino]methyl}phenyl)methylidene]amino}phenyl)-N,N-dimethylethanimidamide
CBNumber: CB11400967
Molecular Formula: C28H32N6
Formula Weight: 452.59
MOL File: 115103-15-6.mol

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tribendimidine Property

Boiling point:: 618.2±65.0 °C(Predicted)
Density: 1.04±0.1 g/cm3(Predicted)
form: Solid
pka: 12.31±0.15(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C28H32N6/c1-21(33(3)4)31-27-15-11-25(12-16-27)29-19-23-7-9-24(10-8-23)20-30-26-13-17-28(18-14-26)32-22(2)34(5)6/h7-20H,1-6H3
InChIKey: XOIOGKHKNQYULW-UHFFFAOYSA-N
SMILES: C1(C=NC2=CC=C(N=C(N(C)C)C)C=C2)=CC=C(C=NC2=CC=C(N=C(N(C)C)C)C=C2)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0025428
Product name: TRIBENDIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.69
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 5mg
Price: $45
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 10mg
Price: $75
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 100mg
Price: $295
Updated: 2021/12/16

AvaChem

Product number: 2706
Product name: Tribendimidine
Packaging: 250mg
Price: $425
Updated: 2021/12/16

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tribendimidine Chemical Properties,Usage,Production

Uses

Tribendimidine is an orally active, broad-spectrum anthelmintic agent, with particularly high activity against A. lumbricoides and N. americanus. Tribendimidine is also an L-type nicotinic acetylcholine receptor (nAChR) agonist[1][2][3].

in vivo

Tribendimidine (75 and 150 mg/kg; p.o.; once) shows inhibition activity against C. sinensis in rats, and shows inhibition against O. viverrini at 400 mg/kg in hamsters^[2].

Animal Model:	C. sinensis infected Female Wistar rats^[2]
Dosage:	75 mg/kg and 150 mg/kg
Administration:	Oral administration, once
Result:	A 99.1% worm burden reduction was achieved at 150 mg/kg, and the worm burden reduction was still significant (68.9%) at 75 mg/kg.

References

[1] Xiao SH, et al. Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop. 2005 Apr;94(1):1-14. DOI:10.1016/j.actatropica.2005.01.013
[2] Keiser J, et al. Evaluation of the in vivo activity of tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini. Antimicrob Agents Chemother. 2007 Mar;51(3):1096-8. DOI:10.1128/AAC.01366-06
[3] Hu Y, et al. The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis. 2009 Aug 11;3(8):e499. DOI:10.1371/journal.pntd.0000499

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View Lastest Price from tribendimidine manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: tribendimidine 115103-15-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-28

115103-15-6, tribendimidineRelated Search:

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tribendimidine

Ethanimidamide, N',N'''-[1,4-phenylenebis(methylidynenitrilo-4,1-phenylene)]bis[N,N-dimethyl-

N'-[4-[[4-[[4-[1-(dimethylamino)ethylideneamino]phenyl]iminomethyl]phenyl]methylideneamino]phenyl]-N,N-dimethylethanimidamide

N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)

N'-(4-{[(4-{[(4-{[1-(dimethylamino)ethylidene]amino}phenyl)imino]methyl}phenyl)methylidene]amino}phenyl)-N,N-dimethylethanimidamide

Tribendimidine, 10 mM in DMSO

N',N'''-(((1,4-Phenylenebis(methaneylylidene))bis(azaneylylidene))bis(4,1-phenylene))bis(N,N-dimethylacetimidamide)

115103-15-6

C28H32N6