Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside

Product Name: Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
CAS No.: 4099-85-8
Chemical Name: Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside
Synonyms: NSC 85191;EINECS 223-865-8;Capecitabine Impurity 32;Capecitabine Impurity 55;2,3-O-Isopropylidene-B-D-ribofuranoside;METHYL 2,3-O-ISOPROPYLIDEN-D-RIBOFURANOSE;(3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-te;2,3-O-isopropylidine-1-O-methylribofuranose;1-OMe-2,3-Isopropuidene-beta-D-ribofuranoside;METHYL 2,3-O-ISOPROPYLIDENE-B-D-RIBOFURANOSIDE
CBNumber: CB1140967
Molecular Formula: C9H16O5
Formula Weight: 204.22
MOL File: 4099-85-8.mol

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Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Property

Boiling point:: 75°C/0.3mm
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in chloroform, dichloromethane, ethanol, ethyl acetate, and methanol
pka: 14.14±0.10(Predicted)
form: Oil
color: Clear Yellow
InChI: InChI=1/C9H16O5/c1-9(2)13-6-5(4-10)12-8(11-3)7(6)14-9/h5-8,10H,4H2,1-3H3/t5-,6-,7-,8-/s3
InChIKey: DXBHDBLZPXQALN-OVDRDRJSNA-N
SMILES: C([C@H]1O[C@@H](OC)[C@]2([H])OC(C)(C)O[C@]12[H])O |&1:1,3,6,13,r|
CAS DataBase Reference: 4099-85-8(CAS DataBase Reference)

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Safety

HS Code: 2940006000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3528
Product name: Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside
Purity: min. 98.0 %
Packaging: 1G
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: M3528
Product name: Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside
Purity: min. 98.0 %
Packaging: 5G
Price: $94
Updated: 2025/07/31

TRC

Product number: M314600
Product name: Methyl2,3-O-Isopropylidene-β-D-ribofuranoside
Packaging: 25g
Price: $130
Updated: 2021/12/16

Usbiological

Product number: M3505-38
Product name: Methyl 2,3-O-Isopropylidene-b-D-ribofuranoside
Packaging: 5g
Price: $319
Updated: 2021/12/16

Usbiological

Product number: 293909
Product name: Methyl 2,3-O-isopropylidene-b-D-ribofuranoside
Packaging: 5g
Price: $322
Updated: 2021/12/16

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Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Chemical Properties,Usage,Production

Chemical Properties

Colourless Liquid

Uses

Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside is used for the manufacture of fine chemicals, and Industrial use resulting in manufacture of intermediates.

Synthesis

67-56-1

532-20-7

67-64-1

4099-85-8

D-ribose (1; 20.0 g, 133.2 mmol) was suspended in a solvent mixture of acetone (100 mL) and methanol (100 mL) at room temperature. Concentrated sulfuric acid (10 mL) was slowly added and the reaction mixture was stirred for 48 hours. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, solid sodium bicarbonate (NaHCO3) was added to neutralize the reaction solution. The insoluble solids were removed by filtration and the filtrate was subsequently concentrated. The concentrated mixture was extracted with ethyl acetate (EtOAc). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the solvent was evaporated to remove the organic solvent. The crude product was purified by silica gel fast column chromatography using hexane/ethyl acetate (5:1, v/v) as eluent to afford the target compound ((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxin-4-yl)methanol as a light yellow oil in 24.4 g (90% yield). The Rf value of the product was 0.2 (eluent: hexane/EtOAc = 5:1, v/v). The specific optical rotation [α]D25 was -80.00 (c 1.00, CHCl3), which is in accordance with the literature value [α]D20 -75.00 (c 1.00, CHCl3).1H NMR (CDCl3, 400 MHz) data were as follows: δ= 4.97 (s, 1H), 4.83 (d, J = 5.7Hz, 1H), 4.58 (d, J = 6.0 Hz, 1H), 4.42 (t, J = 2.7 Hz, 1H), 3.56-3.72 (m, 2H), 3.43 (s, 3H), 3.32 (dd, J = 10.0,3.0 Hz, 1H), 1.49 (s, 3H), 1.32 (s, 3H).

References

[1] Synthesis (Germany), 2017, vol. 49, # 18, p. 4299 - 4302
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 20, p. 7972 - 7990
[3] Journal of the American Chemical Society, 2015, vol. 137, # 10, p. 3558 - 3564
[4] Organic and Biomolecular Chemistry, 2009, vol. 7, # 4, p. 761 - 776
[5] Journal of Fluorine Chemistry, 1993, vol. 60, # 2.3, p. 239 - 250

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside Suppliers

Canada 1 China 106 Germany 3 India 3 Japan 2 United Kingdom 6 United States 16 Global 137

Beijing Qinling Pharmaceutical Co., Ltd.

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View Lastest Price from Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside 4099-85-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Zhuozhou Wenxi import and Export Co., Ltd

Product: Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside 4099-85-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: Methyl-2,3-O–isopropylidene-β-D- ribofuranoside 4099-85-8
Price: US $100.00-90.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg/month or Customized
Release date: 2018-07-25

4099-85-8, Methyl-2,3-O-isopropylidene-beta-D-ribofuranosideRelated Search:

Bensulfuron methyl METSULFURON METHYL Methylparaben Methyl acetate 3-Methyl-2-butanone Cyclopropyl methyl ketone Kresoxim-methyl Methyl acrylate Methyl 2,3,4-tri-O-benzyl-alpha-D-glucopyranoside Methyl-2,3,5-tri-O-benzoyl-alpha-D-arabinofuranoside Methyl-2-deoxy-beta-D-ribofuranoside Thiophanate-methyl Methyl 1,5-Di-O-(4-methylbenzoyl)-2,3-O-isopropylidene-beta-D-ribofuranose Methyl bromide Methyl 2,3-O-isopropylidene-5-O-(p-tolylsulfonyl)-beta-D-ribofuranoside Methyl 2,3-O-isopropylidene-5-O-benzyl-beta-D-ribofuranoside Parathion-methyl

METHYL 2,3-O-ISOPROPYLIDEN-D-RIBOFURANOSE

METHYL-2,3-O-ISOPROPYLIDENE-ALPHA,BETA-D-RIBOFURANOSIDE

METHYL 2,3-O-ISOPROPYLIDENE-B-D-RIBOFURANOSIDE

METHYL 2,3-O-ISOPROPYLIDENE-BETA-D-RIBOFURANOSIDE

EINECS 223-865-8

METHYL 2,3-O-ISOPROPYLIDENE-SS-D-RIBOFURANOSIDE

2,3-O-Isopropylidene-B-D-ribofuranoside

((3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

1-O-Methyl-2-O,3-O-isopropylidene-β-D-ribofuranose

Methyl 2-O,3-O-(1-methylethylidene)-β-D-ribofuranoside

Methyl 2-O,3-O-isopropylidene-β-D-ribofuranoside

NSC 85191

Methyl 2,3-O-isopropylidene-beta-D-ribofuranoside min. 98%

(6-Methoxy-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-methanol

b-D-Ribofuranoside, methyl 2,3-O-(1-methylethylidene)-

Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside

Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside USP/EP/BP

(3aR,4R,6R,6aR)-6-methoxy-2,2-dimethyl-te

TIANFU-CHEM Methyl-2,3-O-isopropylidene-beta-D-ribofuranoside

{6-methoxy-2,2-dimethyl-tetrahydro-2H-furo[3,4-d][1,3]dioxol-4-yl}methanol

Methyl 2,3-O-(1-methylethylidene)-β-D-ribofuranoside

1-OMe-2,3-Isopropuidene-beta-D-ribofuranoside

β-D-Ribofuranoside, methyl 2,3-O-(1-methylethylidene)-

Capecitabine Impurity 32

Capecitabine Impurity 55

2,3-O-isopropylidine-1-O-methylribofuranose

Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, CAS 4099-85-8

4099-85-8

Carbohydrates & Derivatives