Deslorelin

ChemicalBook > CAS DataBase List > Deslorelin

Product Name: Deslorelin
CAS No.: 57773-65-6
Chemical Name: Deslorelin
Synonyms: H 4065;tryptal;somagard;Deslelin;DESORELIN;DESLORELIN;bachem9022;Deslorenlin;Deslelin Acetate;DESLORELIN, >99%
CBNumber: CB1144228
Molecular Formula: C64H83N17O12
Formula Weight: 1282.48
MOL File: 57773-65-6.mol

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Deslorelin Property

Melting point:: >189oC
alpha: D24 -61° (c = 0.37 in 0.1M acetic acid)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: Acetic acid (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.82±0.15(Predicted)
color: White to Off-White
Sequence: Pyr-His-Trp-Ser-Tyr-DTrp-Leu-Arg-Pro-NHEt
InChI: InChI=1/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/s3
InChIKey: GJKXGJCSJWBJEZ-QCOVUDKBNA-N
SMILES: C(C1=CNC2C=CC=CC1=2)[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(N1CCC[C@H]1C(=O)NCC)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC([C@@H]1CCC(=O)N1)=O)CC1N=CNC=1)CC1=CNC2C=CC=CC1=2)CC1C=CC(O)=CC=1 |&1:10,14,22,35,45,49,55,59,62,r|
CAS DataBase Reference: 57773-65-6(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 60
Safety Statements: 53-22-36/37/39-45
WGK Germany: 3
RTECS: OK6755000
HS Code: 3504009000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Usbiological

Product number: D3220-75
Product name: Deslorelin
Packaging: 5mg
Price: $297
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD41614
Product name: Deslorelin acetate
Packaging: 50mg
Price: $333
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364555
Product name: Deslorelin Acetate
Purity: > 95%
Packaging: 1mg
Price: $661.3
Updated: 2021/12/16

Apolloscientific

Product number: BITH3011
Product name: Deslorelin
Packaging: 100mg
Price: $827
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0002052
Product name: DESLORELIN
Purity: 95.00%
Packaging: 5MG
Price: $1010.05
Updated: 2021/12/16

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Deslorelin Chemical Properties,Usage,Production

Description

Deslorelin is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production.

Chemical Properties

White powder, tens of times more biologically active than natural LH-RH, is synthesized by solid-phase or liquid-phase synthesis method using the corresponding protected amino acid monomers as raw materials.

Uses

Induction of ovulation in estrous mares Reproduction control in dogs

Definition

ChEBI: Deslorelin is an oligopeptide.

brand name

Somagard [as acetate] (Roberts Pharmaceutical).

General Description

Deslorelin (brand names: SucroMate, Suprelorin F, Suprelorin 12, Suprelorin-6) is a synthetic hormone used to induce ovulation and manage artificial insemination programs in horses, modulate reproduction in dogs, or manage adrenal disease in ferrets. In the U.S., deslorelin is only FDA approved for use in mares and ferrets, and 'off label' or 'extra-label' use is prohibited at this time.

Side effects

The most common side effects include swelling, sensitivity, and redness or warmth at the injection site. Rarely reported side effects in dogs include prolonged estrus and uterine infections.

Veterinary Drugs and Treatments

Deslorelin is approved for inducing ovulation in estrual mares. There is also interest in developing dosages and dosage forms as a long-term, reversible contraceptive in a variety of animal species, as a treatment for prostatic disease in male dogs, and incontinence in ovariectomized dogs. At the time of writing, deslorelin in not available in the USA, but is marketed in Canada.
In humans, deslorelin has been investigated for treating children with precocious puberty, and in adults for prostate carcinoma, dysmenorrhea, fibroids, and endometriosis.

References

[1] CLAIRE GROSSET. Contraceptive effect and potential side-effects of deslorelin acetate implants in rats (Rattus norvegicus): preliminary observations.[J]. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2012, 76 3: 209-214.
[2] STEFANO ROMAGNOLI. Chronic Use of Deslorelin in Dogs: Six Cases (2005-2022).[J]. Animals, 2023, 13 2. DOI:10.3390/ani13020265.
[3] K E OERTER. Adult height in precocious puberty after long-term treatment with deslorelin.[J]. Journal of Clinical Endocrinology & Metabolism, 1991, 73 6: 1235-1240. DOI:10.1210/jcem-73-6-1235.

Deslorelin Preparation Products And Raw materials

Raw materials

Preparation Products

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Deslorelin Suppliers

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View Lastest Price from Deslorelin manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Deslorelin 57773-65-6
Price: US $30.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 2000kg
Release date: 2024-03-20

Wuhan Cell Pharmaceutical Co., Ltd

Product: Deslorelin Acetate 57773-65-6
Price: US $1.00-9.90/g
Min. Order: 1g
Purity: 99%
Supply Ability: 100kg
Release date: 2023-04-07

Shanghai Getian Industrial Co., LTD

Product: Deslorelin 57773-65-6
Price: US $28.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 20000box
Release date: 2024-04-18

57773-65-6, DeslorelinRelated Search:

Glatiramer acetate POLY(VINYL ACETATE) Ammonium acetate Cellulose acetate Sodium acetate Vinyl acetate Ethyl acetate ACETATE Triptorelin L-Prolinamide D(+)-Tryptophan meterelin PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-LEU-ARG-PRO-GLY-NH2 Luteinizing Hormone Releasing Hormone (LHRH) [des-Gly10, D-Trp6, Pro-NHEt9] (human) (Deslorelin) Lutrelin Deslorelin LHRH(DES-GLY10,D-TRP6,PRO-NHET9),DESLORELIN,RABBITANTI-HUMAN:IH Deslorelin, LHRH (Des-Gly10,D-Trp6,Pro-NHEt9), Rabbit anti-Human, IF Kit

GLP-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET

[D-TRP6, DES-GLY10]-LH-RH ETHYLAMIDE

DESORELIN

DESLORELIN

deslorelin acetate

DESLORELIN (HUMAN)

DES-GLY10,[D-TRP6]-LH-RH ETHYLAMIDE

(DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE

(DES-GLY10,D-TRP6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE (SEA BREAM)

(DES-GLY10,D-TRP6,PRO-NHET9)-LHRH

[DES-GLY10, D-TRP6, PRO-NHET9]-LH-RH (HUMAN)

(DES-GLY10,D-TRP6,PRO-NHET9)-LHRH (SEA BREAM)

(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR

(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR (SEA BREAM)

(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE

[DES-GLY10, D-TRP6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE HUMAN

(DES-GLY10,D-TRP6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE (SEA BREAM)

des-gly10,(D-trp6)luteinizing hormone*releasing H

DES-GLY10,(D-TRP6)LUTEINIZING HORMONE*RE LEASING HOR

1-9-Luteinizing hormone-releasing factor (swine), 6-D-tryptophan-9-(N-ethyl-L-prolinamide)-

PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO NHCH2CH3

PYROGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NH-ETHYL

PYR-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET

PGLU-HIS-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-NHET

luteinizinghormone-releasingfactor(pig),6-d-tryptophan-9-(n-ethyl-l-prolina

mide)-10-deglycinamide-

somagard

tryptal

(Des-Gly10，D-Trp6，Proethylamide9)-LRF

luteinizing hormone releasing hormone (D-Trp^<6^>) analog

Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt acetate salt

Delorelin acetate

(d-trp(sub6)-pro(sup9)-net)-gnrh

(d-trp(sub6)-pro(sup9)-net)-gonadotropinreleasinghormone

(d-trp(sup6)-pro(sup9))-lhrhethylamide

(d-trp(sup6)-pro(sup9))-luteinizinghormone-releasinghormoneethylamide

(d-trp(sup6)-pro(sup9)-net)-gonadotropinreleasinghormon

bachem9022

d-trp(sup6)-pro(sup9)-n-ethylamide-lhrh

(Des-Gly10,D-Trp6,Pro-NHEt9)-LHRH High acetate salt Deslorelin High acetate salt

Deslorelin High acetate salt

Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt High acetate salt

Deslorenlin

Deslelin Acetate

Deslorelin,Deslorelin acetate

H 4065

DESLORELIN, >99%

Deslorelin,H 4065, >99%

Deslorelin Acetate / Deslorelin

Deslorelin impurity

Injectable Lyophillzed Powder Peptides Peptide Deslorelin CAS 57773-65-6

To los gonadorelin

Deslorelin USP/EP/BP

Deslorelin，H 4065

Deslelin

Deslorelin Acetate(net)

57773-65-6

5773-65-6