(R)-N-BOC-4-FLUOROPHENYLGLYCINE

(R)-N-BOC-4-FLUOROPHENYLGLYCINE Property

Melting point:

85.7 °C

Boiling point:

408.4±40.0 °C(Predicted)

Density 

1.2168 (estimate)

storage temp. 

Sealed in dry,Room Temperature

form 

Powder

pka

3.47±0.10(Predicted)

color 

White

CAS DataBase Reference

196707-32-1

Safety

Safety Statements 

24/25

HazardClass 

IRRITANT

HS Code 

29224985

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

(R)-N-BOC-4-FLUOROPHENYLGLYCINE Chemical Properties,Usage,Production

Chemical Properties

white powder

Synthesis

Example 59a Single Enantiomeric Isomer; R Configuration NaHCO3 (1.0 g, 11.9 mmol) was added to a stirred aqueous suspension of (R)-4-fluorophenylglycine (1.0 g, 5.9 mmol). after 30 min, a solution of di-tert-butyl dicarbonate (1.5 g, 7.1 mmol) dissolved in tertiary butanol was slowly added dropwise. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction mixture was diluted with water and the pH was subsequently adjusted to 4-5 with 5% aqueous citric acid.The mixture was extracted with dichloromethane (DCM), the organic layer was separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the title compound (R)-2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid (1.6 g). HPLC-MS (Method 17): retention time (Rt) = 2.25 min; mass spectrum (ES+): m/z = 292 [M + Na]+.

References

[1] Patent: US2015/105397, 2015, A1. Location in patent: Paragraph 0385; 0386; 0387; 0388; 0389