3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE

Product Name: 3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE
CAS No.: 18741-24-7
Chemical Name: 3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE
Synonyms: AKOS BBS-00007268;PDE7 inhibitor S14;PDE7 inhibitor-S14;TIMTEC-BB SBB000936;3-phenyl-2-thioxo-1H-quinazolin-4-one;PDE-7 inhibitor S14,PDE7 inhibitor S14;2-mercapto-3-phenylquinazolin-4(3H)-one;3-Phenyl-2(1H)-thioxoquinazoline-4(3H)-one;1,3-dihydro-3-phenyl-2-thio-quinazolin-4-on;2-Thio-3-phenyl-1,3-dihydroquinazolin-4-one
CBNumber: CB1146893
Molecular Formula: C14H10N2OS
Formula Weight: 254.31
MOL File: 18741-24-7.mol

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3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Property

Melting point:: 313-314°C
Boiling point:: 414.8±28.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
pka: 10.96±0.20(Predicted)

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2933998090
Toxicity: mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04508,

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S525154
Product name: 1,2-DIHYDRO-3-PHENYL-2-THIOXO-4(3H)-QUINAZOLINONE
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2024/03/01

Matrix Scientific

Product number: 047602
Product name: 3-Phenyl-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Purity: >95%
Packaging: 5g
Price: $233
Updated: 2021/12/16

Apolloscientific

Product number: OR14409
Product name: 2,3-Dihydro-3-phenyl-2-thioxoquinazolin-4(1H)-one
Packaging: 5g
Price: $247
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H67-1-45
Product name: 2,3-Dihydro-3-phenyl-2-thioxoquinazolin-4(1H)-one
Packaging: 5G
Price: $272
Updated: 2021/12/16

Matrix Scientific

Product number: 047602
Product name: 3-Phenyl-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Purity: >95%
Packaging: 1g
Price: $102
Updated: 2021/12/16

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3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Chemical Properties,Usage,Production

Uses

PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases[1].

References

[1] Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles DOI:10.3390/ijms22063206

3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Suppliers

China 21 Germany 1 India 1 Ukraine 2 United Kingdom 2 United States 9 Global 36

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18741-24-7, 3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONERelated Search:

3-phenyl-2-sulfanylidene-1H-quinazolin-4-one

3-phenyl-2-thioxo-1H-quinazolin-4-one

3-Phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one

Quinazolin-4-one, 1,3-dihydro-3-phenyl-2-thio-

4(1H)-Quinazolinone,2,3-dihydro-3-phenyl-2-thioxo-

TIMTEC-BB SBB000936

1,3-dihydro-3-phenyl-2-thio-quinazolin-4-on

3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE

3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE

AKOS BBS-00007268

2,3-dihydro-3-phenyl-2-thioxoquinazolin-4(1H)-one

3-Phenyl-1,2,3,4-tetrahydro-2-thioxoquinazolin-4-one

3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin

1,2,3,4-Tetrahydro-3-phenyl-2-thioxoquinazoline-4-one

2-Thioxo-1,2-dihydro-3-phenylquinazoline-4(3H)-one

3-Phenyl-2(1H)-thioxoquinazoline-4(3H)-one

3-Phenyl-2-thioxo-1,2-dihydroquinazoline-4(3H)-one

4-Oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxoquinazoline

1,2-DIHYDRO-3-PHENYL-2-THIOXO-4(3H)-QUINAZOLINONE

2-mercapto-3-phenylquinazolin-4(3H)-one

2-Thio-3-phenyl-1,3-dihydroquinazolin-4-one

3-Phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one

PDE7 inhibitor S14

PDE7 inhibitor-S14

PDE-7 inhibitor S14,PDE7 inhibitor S14

18741-24-7

quinazolinone