ChemicalBook > CAS DataBase List > 3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE

3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE

Product Name
3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE
CAS No.
18741-24-7
Chemical Name
3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE
Synonyms
AKOS BBS-00007268;PDE7 inhibitor S14;PDE7 inhibitor-S14;TIMTEC-BB SBB000936;3-phenyl-2-thioxo-1H-quinazolin-4-one;PDE-7 inhibitor S14,PDE7 inhibitor S14;2-mercapto-3-phenylquinazolin-4(3H)-one;3-Phenyl-2(1H)-thioxoquinazoline-4(3H)-one;1,3-dihydro-3-phenyl-2-thio-quinazolin-4-on;2-Thio-3-phenyl-1,3-dihydroquinazolin-4-one
CBNumber
CB1146893
Molecular Formula
C14H10N2OS
Formula Weight
254.31
MOL File
18741-24-7.mol
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3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Property

Melting point:
313-314°C
Boiling point:
414.8±28.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
pka
10.96±0.20(Predicted)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933998090
Toxicity
mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04508,
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S525154
Product name
1,2-DIHYDRO-3-PHENYL-2-THIOXO-4(3H)-QUINAZOLINONE
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2024/03/01
Matrix Scientific
Product number
047602
Product name
3-Phenyl-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Purity
>95%
Packaging
5g
Price
$233
Updated
2021/12/16
Apolloscientific
Product number
OR14409
Product name
2,3-Dihydro-3-phenyl-2-thioxoquinazolin-4(1H)-one
Packaging
5g
Price
$247
Updated
2021/12/16
SynQuest Laboratories
Product number
8H67-1-45
Product name
2,3-Dihydro-3-phenyl-2-thioxoquinazolin-4(1H)-one
Packaging
5G
Price
$272
Updated
2021/12/16
Matrix Scientific
Product number
047602
Product name
3-Phenyl-2-thioxo-2,3-dihydro-4(1H)-quinazolinone
Purity
>95%
Packaging
1g
Price
$102
Updated
2021/12/16
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3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Chemical Properties,Usage,Production

Uses

PDE7-IN-4 is a phosphodiesterase 7 (PDE7) inhibitor with activity that increases intracellular cyclic adenosine monophosphate (cAMP) levels. PDE7-IN-4 shows potential inhibitory effects in neurotransmission and anti-inflammatory applications. PDE7-IN-4 exerts its biological activity by acting on the cAMP/cAMP response element binding protein (CREB) pathway. The development of PDE7-IN-4 aims to improve its pharmacokinetic characteristics to more effectively target neurodegenerative diseases and other inflammation-related diseases[1].

References

[1] Improved Controlled Release and Brain Penetration of the Small Molecule S14 Using PLGA Nanoparticles DOI:10.3390/ijms22063206

3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE Suppliers

China 21 Germany 1 India 1 Ukraine 2 United Kingdom 2 United States 9 Global 36
Enamine
Tel
--
Fax
--
Email
enamine@enamine.net
Country
Ukraine
ProdList
6216
Advantage
67
UkrOrgSynthesis Ltd.
Tel
--
Fax
--
Email
y.barysheva@ukrorgsynth.com
Country
Ukraine
ProdList
6230
Advantage
38

18741-24-7, 3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONERelated Search:

3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE 3-(4-ETHOXYPHENYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 7-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 3-(4-BROMO-3-METHYLPHENYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 3-(2-FLUORO-PHENYL)-2-THIOXO-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE 6-CHLORO-3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 3-(4-FLUORO-PHENYL)-2-THIOXO-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE 3-(2,5-DIMETHOXYPHENYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 3-(4-BROMOPHENYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 3-(3-METHOXYPHENYL)-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE 3-(2,4-DICHLORO-PHENYL)-2-THIOXO-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE 3-(4-TRIFLUOROMETHOXYPHENYL)-2-THIOXO-1,3-DIHYDROQUINAZOLIN-4-ONE 3-(3-FLUORO-PHENYL)-2-THIOXO-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE 2-THIOXO-3-(3-TRIFLUOROMETHYL-PHENYL)-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE 3-(2,4-DIFLUOROPHENYL)-2-THIOXO-1,3-DIHYDROQUINAZOLIN-4-ONE 3-(3,4-DICHLORO-PHENYL)-2-THIOXO-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE 3-(3-CHLORO-PHENYL)-2-THIOXO-2,3-DIHYDRO-1H-QUINAZOLIN-4-ONE N-(4-(4-OXO-2-THIOXO-1,3-DIHYDROQUINAZOLIN-3-YL)PHENYL)ETHANAMIDE

  • 3-phenyl-2-sulfanylidene-1H-quinazolin-4-one
  • 3-phenyl-2-thioxo-1H-quinazolin-4-one
  • 3-Phenyl-2-thioxo-2,3-dihydro-1H-quinazolin-4-one
  • Quinazolin-4-one, 1,3-dihydro-3-phenyl-2-thio-
  • 4(1H)-Quinazolinone,2,3-dihydro-3-phenyl-2-thioxo-
  • TIMTEC-BB SBB000936
  • 1,3-dihydro-3-phenyl-2-thio-quinazolin-4-on
  • 3-PHENYL-2-THIOXO-2,3-DIHYDRO-4(1H)-QUINAZOLINONE
  • 3-PHENYL-2-THIOXO-1,2,3,4-TETRAHYDROQUINAZOLIN-4-ONE
  • AKOS BBS-00007268
  • 2,3-dihydro-3-phenyl-2-thioxoquinazolin-4(1H)-one
  • 3-Phenyl-1,2,3,4-tetrahydro-2-thioxoquinazolin-4-one
  • 3-Phenyl-2-thioxo-1,2,3,4-tetrahydroquinazolin
  • 1,2,3,4-Tetrahydro-3-phenyl-2-thioxoquinazoline-4-one
  • 2-Thioxo-1,2-dihydro-3-phenylquinazoline-4(3H)-one
  • 3-Phenyl-2(1H)-thioxoquinazoline-4(3H)-one
  • 3-Phenyl-2-thioxo-1,2-dihydroquinazoline-4(3H)-one
  • 4-Oxo-3-phenyl-1,2,3,4-tetrahydro-2-thioxoquinazoline
  • 1,2-DIHYDRO-3-PHENYL-2-THIOXO-4(3H)-QUINAZOLINONE
  • 2-mercapto-3-phenylquinazolin-4(3H)-one
  • 2-Thio-3-phenyl-1,3-dihydroquinazolin-4-one
  • 3-Phenyl-2-thioxo-2,3-dihydroquinazolin-4(1H)-one
  • PDE7 inhibitor S14
  • PDE7 inhibitor-S14
  • PDE-7 inhibitor S14,PDE7 inhibitor S14
  • 18741-24-7
  • quinazolinone