ChemicalBook > CAS DataBase List > 2,3-Diamino-5-trifluoromethylpyridine

2,3-Diamino-5-trifluoromethylpyridine

Product Name
2,3-Diamino-5-trifluoromethylpyridine
CAS No.
107867-51-6
Chemical Name
2,3-Diamino-5-trifluoromethylpyridine
Synonyms
109527;2,3-Diamino-5-trifluoromethylpyridin;2,3-Diamino-5-trifluoromethylpyridine;5-(trifluoromethyl)-2,3-pyridinediamine;5-(TrifluoroMethyl)pyridine-2,3-diaMine;2,3-PyridinediaMine,5-(trifluoroMethyl)-;5-(Trifluoromethyl)pyridine-2,3-diamine 98%
CBNumber
CB11471051
Molecular Formula
C6H6F3N3
Formula Weight
177.13
MOL File
107867-51-6.mol
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2,3-Diamino-5-trifluoromethylpyridine Property

Boiling point:
296.7±40.0 °C(Predicted)
Density 
1.467±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
4.43±0.49(Predicted)
Appearance
Light brown to yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific
Product number
PC51080
Product name
5-(Trifluoromethyl)pyridine-2,3-diamine
Purity
98%
Packaging
100mg
Price
$99
Updated
2021/12/16
Apolloscientific
Product number
PC51080
Product name
5-(Trifluoromethyl)pyridine-2,3-diamine
Purity
98%
Packaging
250mg
Price
$159
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-3-U0
Product name
5-(Trifluoromethyl)pyridine-2,3-diamine
Packaging
100mg
Price
$159
Updated
2021/12/16
SynQuest Laboratories
Product number
3H30-3-U0
Product name
5-(Trifluoromethyl)pyridine-2,3-diamine
Packaging
250mg
Price
$255
Updated
2021/12/16
Apolloscientific
Product number
PC51080
Product name
5-(Trifluoromethyl)pyridine-2,3-diamine
Purity
98%
Packaging
1g
Price
$396
Updated
2021/12/16
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2,3-Diamino-5-trifluoromethylpyridine Chemical Properties,Usage,Production

Synthesis

79456-30-7

107867-51-6

General procedure for the synthesis of 2,3-diamino-5-trifluoromethylpyridine from 2-amino-3-bromo-5-trifluoromethylpyridine: In an autoclave reactor, 40 g of 2-amino-3-bromo-5-trifluoromethylpyridine, 2.2 g of copper(II) acetylacetonate, 6.6 g of acetylacetonate, 59 g of cesium carbonate, and 105 mL of N-methyl pyrrolidinone (NMP) were added in sequence. Under cooling in an ice bath, 25 mL of 28% ammonia solution was slowly added. After sealing the reactor, the reaction system was warmed to 110 °C and the reaction was stirred at this temperature for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature in an ice bath, diluted with water and extracted with ethyl acetate. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give 15 g of 2,3-diamino-5-trifluoromethylpyridine.1H-NMR (CDCl3) δ of 2,3-diamino-5-trifluoromethylpyridine: 7.93 (1H, d), 7.04 (1H, d), 4.71 (2H, brs), 3.46 (2H, brs).

References

[1] Patent: EP2865266, 2015, A1. Location in patent: Paragraph 0677

2,3-Diamino-5-trifluoromethylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,3-Diamino-5-trifluoromethylpyridine Suppliers

China 60 Germany 1 India 1 United Kingdom 1 United States 7 Global 70
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107867-51-6, 2,3-Diamino-5-trifluoromethylpyridineRelated Search:

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  • 5-(Trifluoromethyl)pyridine-2,3-diamine 98%
  • 109527
  • 5-(TrifluoroMethyl)pyridine-2,3-diaMine
  • 2,3-PyridinediaMine,5-(trifluoroMethyl)-
  • 2,3-Diamino-5-trifluoromethylpyridine
  • 2,3-Diamino-5-trifluoromethylpyridin
  • 5-(trifluoromethyl)-2,3-pyridinediamine
  • 107867-51-6
  • C6H6N3F3
  • Pyridine series