METHYLENEBIS(PHOSPHONIC DICHLORIDE)

Product Name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
CAS No.: 1499-29-2
Chemical Name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Synonyms: bis(dichlorophosphoryl)methane;BIS(DICHLOROPHOSPHONYL)METHANE;Bis-(dichlorophosphinyl)-methane;METHYLENEDIPHOSPHONIC DICHLORIDE;Methylenedisphosphonic Dichloride;METHYLENEBIS(PHOSPHONIC DICHLORIDE);P,P′-Methylenebis[phosphonic dichloride;Phosphonic dichloride, P,P'-methylenebis-
CBNumber: CB1147951
Molecular Formula: CH2Cl4O2P2
Formula Weight: 249.78
MOL File: 1499-29-2.mol

More

Less

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Property

Melting point:: 102-104 °C(lit.)
Boiling point:: 329.0±25.0 °C(Predicted)
Density: 1.798±0.06 g/cm3(Predicted)
solubility: Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly)
form: crystalline powder
color: Faint beige
Stability:: Moisture Sensitive

More

Less

Safety

Hazard Codes: C
Risk Statements: 14-34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3261 8/PG 1
WGK Germany: 3
HS Code: 2931599090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 447714
Product name: Methylenebis(phosphonic dichloride)
Purity: 97%
Packaging: 5g
Price: $163
Updated: 2024/03/01

TRC

Product number: M304305
Product name: Methylenebis(phosphonic dichloride)
Packaging: 1g
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: OGM0001314
Product name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Purity: 95.00%
Packaging: 1G
Price: $247.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: OGM0001314
Product name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Purity: 95.00%
Packaging: 5G
Price: $906.05
Updated: 2021/12/16

More

Less

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Chemical Properties,Usage,Production

Description

Methylenebis (phosphonic dichloride) is an organophosphorus compound commonly used in phosphonation reactions. It is more reactive and faster than POCl. This is due to the fact that the phosphorus centre is more electrophilic due to the lack of electron feedback from the CH2 group.

Chemical Properties

Crystals of the Methylenebis(phosphonic dichloride) are monoclinic, space group C2/c, with a= 15·866(5), b= 5·845(1), c= 9·161 (3)A, β= 106·59(2)°, Z= 4. The molecules, which display a crystallographically imposed C2 symmetry, are linked together through two C–H ? O(P) hydrogen bonds, of length 3·23(1)A, into infinite chains in the z direction. Rigid-body analysis reveals that pronounced rotational and translational motions are associated with the axis of minimum inertia and least cross-section. Bond lengths (corrected for libration) are: P–Cl 1·994(2) and 1·997 (2), PO 1·463(4), P–C 1·804(4)A; angle P–C–P 116·4(4)°, the structure was solved by direct methods and refined by full-matrix least-squares to R 0·041 for 641 diffractometer-measured unique reflections^[1].

Uses

Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.

Application

Methylenebis (phosphonic dichloride) can be used for the following studies:
(1) Synthesis of mycophenolic methylenebis(phosphonate) derivatives.
(2) Phosphonylation of nucleosides.
(3) Preparation of P,P′-partial esters of methylenebisphosphonic acid.
(4) Synthesis of symmetrical di- and tetra- esters of methylenebisphosphonic acid.

References

[1] SHELDRICK W. Crystal structure of methylenebis(phosphonic dichloride)[J]. Journal of The Chemical Society-dalton Transactions, 1975. DOI:10.1039/DT9750000943.

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Suppliers

China 66 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 77

Anhui Xunrui Chemical Co., Ltd

Tel: 19159025340
Email: sunrui@hfshly.com
Country: China
ProdList: 130
Advantage: 58

Shanghai Langruibang Pharmaceutical Technology Co., Ltd

Tel: 010-88755821 18612220856
Email: marketing@langrb.com
Country: China
ProdList: 213
Advantage: 58

BEIJING EAGLE SKY PHARMATECH CO., LTD

Tel: 010-88755821 13911359480
Email: sophia_818@126.com
Country: China
ProdList: 328
Advantage: 55

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 4986
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44689
Advantage: 61

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11655
Advantage: 64

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9648
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51456
Advantage: 80

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 1998
Advantage: 55

More

Less

View Lastest Price from METHYLENEBIS(PHOSPHONIC DICHLORIDE) manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methylenediphosphonic dichloride 1499-29-2
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-16

Henan Fengda Chemical Co., Ltd

Product: METHYLENEBIS(PHOSPHONIC DICHLORIDE) 1499-29-2
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

Qiuxian Baitai New Material Co., LTD

Product: METHYLENEBIS(PHOSPHONIC DICHLORIDE) 1499-29-2
Price: US $50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-10-15

1499-29-2, METHYLENEBIS(PHOSPHONIC DICHLORIDE)Related Search:

BIS(DICHLOROPHOSPHINO)METHANE METHYLPHOSPHONIC DICHLORIDE METHYLDICHLOROPHOSPHINE BIS(PHOSPHINO)METHANE METHYLENEBIS(PHOSPHONIC DICHLORIDE)

METHYLENEDIPHOSPHONIC DICHLORIDE

METHYLENEBIS(PHOSPHONIC DICHLORIDE)

BIS(DICHLOROPHOSPHONYL)METHANE

Bis-(dichlorophosphinyl)-methane

bis(dichlorophosphoryl)methane

Phosphonic dichloride, P,P'-methylenebis-

Methylenedisphosphonic Dichloride

P,P′-Methylenebis[phosphonic dichloride

1499-29-2

CH2Cl4O2P2

CH2POCl22

Building Blocks

Phosphorus Halides

Phosphorus Compounds

Organic Building Blocks

Building Blocks

Chemical Synthesis

Organic Building Blocks

Phosphorus Compounds

Phosphorus Halides

Organic Building Blocks

Phosphorus Compounds

Phosphorus Halides