ChemicalBook > CAS DataBase List > METHYLENEBIS(PHOSPHONIC DICHLORIDE)

METHYLENEBIS(PHOSPHONIC DICHLORIDE)

Product Name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
CAS No.: 1499-29-2
Chemical Name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Synonyms: bis(dichlorophosphoryl)methane;BIS(DICHLOROPHOSPHONYL)METHANE;Bis-(dichlorophosphinyl)-methane;METHYLENEDIPHOSPHONIC DICHLORIDE;Methylenedisphosphonic Dichloride;METHYLENEBIS(PHOSPHONIC DICHLORIDE);P,P′-Methylenebis[phosphonic dichloride;Phosphonic dichloride, P,P'-methylenebis-
CBNumber: CB1147951
Molecular Formula: CH2Cl4O2P2
Formula Weight: 249.78
MOL File: 1499-29-2.mol

Less

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Property

Melting point:: 102-104 °C(lit.)
Boiling point:: 329.0±25.0 °C(Predicted)
Density: 1.798±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
solubility: Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly)
form: crystalline powder
color: Faint beige
Stability:: Moisture Sensitive
InChI: InChI=1S/CH2Cl4O2P2/c2-8(3,6)1-9(4,5)7/h1H2
InChIKey: VRXYCDTWIOCJBH-UHFFFAOYSA-N
SMILES: P(Cl)(Cl)(=O)CP(Cl)(Cl)=O

Less

Safety

Hazard Codes: C
Risk Statements: 14-34
Safety Statements: 26-27-36/37/39-45
RIDADR: UN 3261 8/PG 1
WGK Germany: 3
HS Code: 2931599090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 447714
Product name: Methylenebis(phosphonic dichloride)
Purity: 97%
Packaging: 5g
Price: $128
Updated: 2025/07/31

TRC

Product number: M304305
Product name: Methylenebis(phosphonic dichloride)
Packaging: 1g
Price: $140
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: OGM0001314
Product name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Purity: 95.00%
Packaging: 1G
Price: $247.8
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: OGM0001314
Product name: METHYLENEBIS(PHOSPHONIC DICHLORIDE)
Purity: 95.00%
Packaging: 5G
Price: $906.05
Updated: 2021/12/16

Less

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Chemical Properties,Usage,Production

Description

Methylenebis (phosphonic dichloride) is an organophosphorus compound commonly used in phosphonation reactions. It is more reactive and faster than POCl. This is due to the fact that the phosphorus centre is more electrophilic due to the lack of electron feedback from the CH2 group.

Chemical Properties

Crystals of the Methylenebis(phosphonic dichloride) are monoclinic, space group C2/c, with a= 15·866(5), b= 5·845(1), c= 9·161 (3)A, β= 106·59(2)°, Z= 4. The molecules, which display a crystallographically imposed C2 symmetry, are linked together through two C–H ? O(P) hydrogen bonds, of length 3·23(1)A, into infinite chains in the z direction. Rigid-body analysis reveals that pronounced rotational and translational motions are associated with the axis of minimum inertia and least cross-section. Bond lengths (corrected for libration) are: P–Cl 1·994(2) and 1·997 (2), PO 1·463(4), P–C 1·804(4)A; angle P–C–P 116·4(4)°, the structure was solved by direct methods and refined by full-matrix least-squares to R 0·041 for 641 diffractometer-measured unique reflections^[1].

Uses

Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.

Application

Methylenebis (phosphonic dichloride) can be used for the following studies:
(1) Synthesis of mycophenolic methylenebis(phosphonate) derivatives.
(2) Phosphonylation of nucleosides.
(3) Preparation of P,P′-partial esters of methylenebisphosphonic acid.
(4) Synthesis of symmetrical di- and tetra- esters of methylenebisphosphonic acid.

References

[1] SHELDRICK W. Crystal structure of methylenebis(phosphonic dichloride)[J]. Journal of The Chemical Society-dalton Transactions, 1975. DOI:10.1039/DT9750000943.

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Preparation Products And Raw materials

Raw materials

Preparation Products

Less

METHYLENEBIS(PHOSPHONIC DICHLORIDE) Suppliers

China 73 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 84

Anhui Xunrui Chemical Co., Ltd

Tel: 19159025340
Email: sunrui@hfshly.com
Country: China
ProdList: 469
Advantage: 58

Shanghai Langruibang Pharmaceutical Technology Co., Ltd

Tel: 010-88755821 18612220856
Email: marketing@langrb.com
Country: China
ProdList: 413
Advantage: 58

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

BEIJING EAGLE SKY PHARMATECH CO., LTD

Tel: 010-88755821 13911359480
Email: sophia_818@126.com
Country: China
ProdList: 294
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.

Tel: 027-65388397 18164111589
Fax: 027-65388397
Email: 3321478047@qq.com
Country: China
ProdList: 2007
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Wuxi AppTec

Tel: 022-59987777 13552403979
Email: jia_guoqiang@wuxiapptec.com
Country: China
ProdList: 22345
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

ROSEWA HOLDING GROUP CO.,LIMITED

Tel: +86-023-62871537
Email: sales@rosewachem.com
Country: China
ProdList: 2803
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +8615838112936
Email: alfa10@alfachem.cn
Country: China
ProdList: 12921
Advantage: 58

Finetech Industry Limited

Tel: +86-27-8746-5837 +8619945049750
Fax: 86 27 87772287
Email: info@finetechnology-ind.com
Country: China
ProdList: 9629
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Qiuxian Baitai New Material Co., LTD

Tel: +8618330912755
Fax: +8619932103556
Email: sale2@hbyalin.com
Country: China
ProdList: 1658
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Henan Weituxi Chemical Technology Co., Ltd.

Tel: 0371-63284658 18135795563
Fax: QQ:2885349392
Email: 2885349392@qq.com
Country: China
ProdList: 9992
Advantage: 58

Hubei Zhonglong Kangsheng Fine Chemical Co., Ltd.

Tel: 027-83855385 13407122916
Fax: 027-83855385
Email: 13037171113@163.com
Country: China
ProdList: 995
Advantage: 58

Hubei xin bonus chemical co. LTD

Tel: 86-13657291602
Fax: 027-59338440
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 22963
Advantage: 58

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Email: sales@accelachem.com
Country: China
ProdList: 10467
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 021-021-13773155751 19975051755
Email: 260924549@qq.com
Country: China
ProdList: 10524
Advantage: 58

Wuhan Yuqing Jiaheng Pharmaceutical Co., Ltd

Tel: 027-83855382 15926260338
Email: 15926260338@163.com
Country: China
ProdList: 984
Advantage: 58

Shanghai Jiegu Biotechnology Co., Ltd.

Tel: 021-51698675
Email: sales@jiejiegroup.com
Country: China
ProdList: 8020
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81139210 +86-18192627656
Fax: +86-29-88380327
Email: 1059@dideu.com
Country: China
ProdList: 3588
Advantage: 58

ShangHai Anpel Co, Ltd.

Tel: 18501792038 18502138905
Email: shanpel@anpel.com.cn
Country: China
ProdList: 9611
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 9997
Advantage: 58

Wuxi Helen Biotechnology Co., Ltd.,

Tel: 0510-85629785 18013409632
Fax: 0510-85625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 14081
Advantage: 58

Nanjing F&S Pharmatech Co., Ltd.

Tel: 025-86950358 13390612682
Email: wangjinyu@fshpharm.com
Country: China
ProdList: 170
Advantage: 58

Shaoguan Mingtu Chemical Co., Ltd

Tel: 13411131983
Fax: 0751-2888656
Email: 2407385074@qq.com
Country: China
ProdList: 2034
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9847
Advantage: 58

Hubei Wande Chemical Co., Ltd

Tel: 027-027-59210159 15377098680
Fax: 027-59210159
Email: 1148280011@qq.com
Country: China
ProdList: 9835
Advantage: 58

Hubei xingongli Chemical Co., Ltd

Tel: 027-027-59106151 15172325309
Fax: 027-59503710
Email: 1400858877@qq.com
Country: China
ProdList: 9928
Advantage: 58

Nanjing Yili Biotechnology Co., Ltd.

Tel: 15380789538
Email: 2885743537@qq.com
Country: China
ProdList: 8205
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Haisco Pharmaceutical Group Co., Ltd.

Tel: 028-6725-0449 19382244693
Email: luoyan1@haisco.com
Country: China
ProdList: 174
Advantage: 58

Henan Tongping Chemical Products Co. LTD

Tel: 13402251831
Email: 3635790176@qq.com
Country: China
ProdList: 106
Advantage: 58

Shanghai New Bo Biomedical Technology Co., LTD

Tel: 021-18800336901 15821600833
Email: muyouren139@163.com
Country: China
ProdList: 385
Advantage: 58

Hubei DAHAO Chemical Co., Ltd.

Tel: 027-027-59106191 13986034860
Email: 1400828855@qq.com
Country: China
ProdList: 8919
Advantage: 58

Henan Dobe Chemical Co. , Ltd.

Tel: 0370-6999054 17550096163
Email: 3189729795@qq.com
Country: China
ProdList: 7172
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10674
Advantage: 58

Shanghai Yanze Chemical Co., Ltd.

Tel: 15345144255; 15345144255
Email: 260924549@qq.com
Country: China
ProdList: 3129
Advantage: 58

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9844
Advantage: 58

Hubei Chenghai Chemical Co., Ltd

Tel: 027-59220433 18327245847
Email: 1400838877@qq.com
Country: China
ProdList: 9875
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Foshan Yuhang New Materials Co., Ltd

Tel: 0757-18928797409 13078814179
Email: 1670287326@qq.com
Country: China
ProdList: 963
Advantage: 58

Shandong Mingde Biotechnology Co., Ltd.

Tel: 18560864701
Email: 643971@qq.com
Country: China
ProdList: 6100
Advantage: 58

Shanghai Titan Enterprise Development Co., Ltd

Tel: 16621224781
Email: syy@titansci.com
Country: China
ProdList: 2896
Advantage: 58

Less

View Lastest Price from METHYLENEBIS(PHOSPHONIC DICHLORIDE) manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Methylenediphosphonic dichloride 1499-29-2
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2020-01-16

Henan Fengda Chemical Co., Ltd

Product: METHYLENEBIS(PHOSPHONIC DICHLORIDE) 1499-29-2
Price: US $50.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-22

Qiuxian Baitai New Material Co., LTD

Product: METHYLENEBIS(PHOSPHONIC DICHLORIDE) 1499-29-2
Price: US $50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-10-15

1499-29-2, METHYLENEBIS(PHOSPHONIC DICHLORIDE)Related Search:

BIS(DICHLOROPHOSPHINO)METHANE METHYLPHOSPHONIC DICHLORIDE METHYLDICHLOROPHOSPHINE BIS(PHOSPHINO)METHANE METHYLENEBIS(PHOSPHONIC DICHLORIDE)

METHYLENEDIPHOSPHONIC DICHLORIDE

METHYLENEBIS(PHOSPHONIC DICHLORIDE)

BIS(DICHLOROPHOSPHONYL)METHANE

Bis-(dichlorophosphinyl)-methane

bis(dichlorophosphoryl)methane

Phosphonic dichloride, P,P'-methylenebis-

Methylenedisphosphonic Dichloride

P,P′-Methylenebis[phosphonic dichloride

1499-29-2

CH2Cl4O2P2

CH2POCl22

Building Blocks

Phosphorus Halides

Phosphorus Compounds

Organic Building Blocks

Building Blocks

Chemical Synthesis

Organic Building Blocks

Phosphorus Compounds

Phosphorus Halides

Organic Building Blocks

Phosphorus Compounds

Phosphorus Halides