METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- Product Name
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- CAS No.
- 1499-29-2
- Chemical Name
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- Synonyms
- bis(dichlorophosphoryl)methane;BIS(DICHLOROPHOSPHONYL)METHANE;Bis-(dichlorophosphinyl)-methane;METHYLENEDIPHOSPHONIC DICHLORIDE;Methylenedisphosphonic Dichloride;METHYLENEBIS(PHOSPHONIC DICHLORIDE);P,P′-Methylenebis[phosphonic dichloride;Phosphonic dichloride, P,P'-methylenebis-
- CBNumber
- CB1147951
- Molecular Formula
- CH2Cl4O2P2
- Formula Weight
- 249.78
- MOL File
- 1499-29-2.mol
METHYLENEBIS(PHOSPHONIC DICHLORIDE) Property
- Melting point:
- 102-104 °C(lit.)
- Boiling point:
- 329.0±25.0 °C(Predicted)
- Density
- 1.798±0.06 g/cm3(Predicted)
- solubility
- Chloroform (Slightly), DMSO (Sparingly), Ethyl Acetate (Sparingly), Methanol (Slightly)
- form
- crystalline powder
- color
- Faint beige
- Stability:
- Moisture Sensitive
Safety
- Hazard Codes
- C
- Risk Statements
- 14-34
- Safety Statements
- 26-27-36/37/39-45
- RIDADR
- UN 3261 8/PG 1
- WGK Germany
- 3
- HS Code
- 2931599090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 447714
- Product name
- Methylenebis(phosphonic dichloride)
- Purity
- 97%
- Packaging
- 5g
- Price
- $163
- Updated
- 2024/03/01
- Product number
- M304305
- Product name
- Methylenebis(phosphonic dichloride)
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- OGM0001314
- Product name
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $247.8
- Updated
- 2021/12/16
- Product number
- OGM0001314
- Product name
- METHYLENEBIS(PHOSPHONIC DICHLORIDE)
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $906.05
- Updated
- 2021/12/16
METHYLENEBIS(PHOSPHONIC DICHLORIDE) Chemical Properties,Usage,Production
Description
Methylenebis (phosphonic dichloride) is an organophosphorus compound commonly used in phosphonation reactions. It is more reactive and faster than POCl. This is due to the fact that the phosphorus centre is more electrophilic due to the lack of electron feedback from the CH2 group.
Chemical Properties
Crystals of the Methylenebis(phosphonic dichloride) are monoclinic, space group C2/c, with a= 15·866(5), b= 5·845(1), c= 9·161 (3)A, β= 106·59(2)°, Z= 4. The molecules, which display a crystallographically imposed C2 symmetry, are linked together through two C–H ? O(P) hydrogen bonds, of length 3·23(1)A, into infinite chains in the z direction. Rigid-body analysis reveals that pronounced rotational and translational motions are associated with the axis of minimum inertia and least cross-section. Bond lengths (corrected for libration) are: P–Cl 1·994(2) and 1·997 (2), PO 1·463(4), P–C 1·804(4)A; angle P–C–P 116·4(4)°, the structure was solved by direct methods and refined by full-matrix least-squares to R 0·041 for 641 diffractometer-measured unique reflections[1].
Uses
Methylenebis(phosphonic Dichloride) is used as a reagent in synthesis of several organic compounds including that of nucleoside 5'-methylenebis(phosphonate)s and bisphosphonated glycopeptide prodrugs for the treatment of osteomyelitis.
Application
Methylenebis (phosphonic dichloride) can be used for the following studies:
(1) Synthesis of mycophenolic methylenebis(phosphonate) derivatives.
(2) Phosphonylation of nucleosides.
(3) Preparation of P,P′-partial esters of methylenebisphosphonic acid.
(4) Synthesis of symmetrical di- and tetra- esters of methylenebisphosphonic acid.
References
[1] SHELDRICK W. Crystal structure of methylenebis(phosphonic dichloride)[J]. Journal of The Chemical Society-dalton Transactions, 1975. DOI:10.1039/DT9750000943.
METHYLENEBIS(PHOSPHONIC DICHLORIDE) Preparation Products And Raw materials
Raw materials
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View Lastest Price from METHYLENEBIS(PHOSPHONIC DICHLORIDE) manufacturers
- Product
- Methylenediphosphonic dichloride 1499-29-2
- Price
- US $1.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2020-01-16
- Product
- METHYLENEBIS(PHOSPHONIC DICHLORIDE) 1499-29-2
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
- Product
- METHYLENEBIS(PHOSPHONIC DICHLORIDE) 1499-29-2
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500ton/Month
- Release date
- 2021-10-15