1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

Product Name: 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione
CAS No.: 16233-51-5
Chemical Name: 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione
Synonyms: 102776;2,4-Dihydr;2-d]pyriMidine-2;2-chloro-4-Morpholinothieno;hieno[3,2-d]pyrimidine-2,4-diol;thieno[3,2-d]pyrimidine-2,4-diol;1H-Thieno[3,2-d]pyrimidine-2,4-dione;Thieno[3,2-d]pyriMidine-2,4-diol(8CI);1H-Thieno[3,2-d][1,3]oxazine-2,4-dione;Thieno[3,2-d]pyrimidine2,4(1H,3H)-dione
CBNumber: CB11483285
Molecular Formula: C6H4N2O2S
Formula Weight: 168.17
MOL File: 16233-51-5.mol

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1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Property

Melting point:: >300 °C
Density: 1.517±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 10.40±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C6H4N2O2S/c9-5-4-3(1-2-11-4)7-6(10)8-5/h1-2H,(H2,7,8,9,10)
InChIKey: QAFVXBQPQCSSLI-UHFFFAOYSA-N
SMILES: C1(=O)NC(=O)C2SC=CC=2N1
CAS DataBase Reference: 16233-51-5

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Safety

Risk Statements: 20/21/22
Safety Statements: 24/25-36/37
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T344305
Product name: Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Packaging: 10g
Price: $1230
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0094738
Product name: 2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE
Purity: 95.00%
Packaging: 10G
Price: $1510.74
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 62088
Product name: Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Packaging: 10g
Price: $2120
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0094738
Product name: 2,4-DIHYDROXYTHIENO[3,2-D]PYRIMIDINE
Purity: 95.00%
Packaging: 5G
Price: $1081.08
Updated: 2021/12/16

AK Scientific

Product number: W3535
Product name: 1H-Thieno[3,2-d]pyrimidine-2,4-dione
Packaging: 5g
Price: $103
Updated: 2021/12/16

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1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Chemical Properties,Usage,Production

Chemical Properties

Grey solid

Uses

1H-Thieno[3,4-d]pyrimidine-2,4-dione is an analog of thieno[3,4-d]pyrimidine and can serve as an inhibitor of dipeptidyl peptidase IV, PKD (serine/threonine kinases) as well as take part in the synthesis of antagonists of the humane adenosine A2B receptor.

Synthesis

22288-78-4

16233-51-5

The general procedure for the synthesis of thieno[3,2-d]pyrimidine-2,4-dione from methyl 3-amino-2-thiophenecarboxylate was as follows: to a mixed solution containing methyl 3-amino-2-thiophenecarboxylate (101) (100.0 g, 636.9 mmol, 1.0 eq.), acetic acid (705 mL), and water (600 mL) was added slowly over a period of 1 h. To a mixture containing methyl 3-aminothiophene-2-carboxylate (101) ( 154.8 g, 1.91 mol, 3.0 eq.) of an aqueous solution (326 mL). The reaction mixture was stirred at room temperature for 20 hours before being filtered and the filter cake was washed with deionized water (500 mL). The resulting solid was transferred to an appropriately sized reactor, 2M aqueous sodium hydroxide solution (1.65 L) was added and the slurry was stirred for 2 h. The formation of the target product, thieno[3,2-d]pyrimidine-2,4-dione, was confirmed by LCMS. Subsequently, the reaction mixture was cooled to 10 °C and the pH was adjusted to 5.0-6.0 by slow addition of 3M aqueous hydrochloric acid (1.29 L). The slurry was filtered, the solids were washed with deionized water (700 mL) and dried in a vacuum oven at 50 °C for 24 h. Compound 102 (100 g, 94% yield) was obtained as an off-white solid. lCMS (m/z): 169.1 [ M + H]+. 1H NMR (400MHz, DMSO-d6): δ 6.92 (d, J=5.2Hz, 1H), 8.04 (d, J=5.2Hz, 1H), 11.14 (s, 1H), 11.51 (s, 1H).

References

[1] Patent: WO2018/85342, 2018, A1. Location in patent: Page/Page column 25; 30
[2] Patent: WO2011/49332, 2011, A2. Location in patent: Page/Page column 16
[3] Patent: US2012/277424, 2012, A1. Location in patent: Page/Page column 7
[4] Journal of Chemical Research, Miniprint, 1993, # 2, p. 548 - 575
[5] Patent: CN103980287, 2016, B. Location in patent: Paragraph 0117; 0118; 0119

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione Suppliers

Canada 1 China 151 India 1 United States 22 Global 175

Anhui Shite Pharmaceutical Technology Co., LTD

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View Lastest Price from 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione 16233-51-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-07

Career Henan Chemical Co

Product: 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione 16233-51-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2019-05-25

16233-51-5, 1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dioneRelated Search:

THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE Thieno[2,3-b]pyridine (8CI,9CI) THIENO[3,2-B]THIOPHENE-2-CARBOXYLIC ACID thieno[3,2-c]pyridine Thieno[3,2-b]thiophene-2,5-dicarboxaldehyde tert-butyl thiazol-5-ylcarbamate Thieno[2,3-b]pyridine-5-carboxylic acid Thiazole-4-carboxaldehyde Methyl 2-Thiazolecarboxylate Thiazole-5-carboxylic acid THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Thieno[3,2-b]pyridine-6-carboxylic acid Thieno[3,2-b]thiophene METHYL THIOPHENE-2-CARBOXYLATE methyl thiazolo[4,5-b]pyridine-6-carboxylate THIENO(3 2-B)PYRIDIN-7-OL Thieno[2,3-c]pyridine-6(5H)-acetic acid, -(2-chlorophenyl)-4,7-dihydro-, methyl ester Thieno[3,2-b]pyridine, 3-amino- (6CI)

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione

hieno[3,2-d]pyrimidine-2,4-diol

1H-Thieno[3,2-d]pyrimidine-2,4-dione

2,4-Dihydroxythieno[3,2-d]pyrimidine ,97%

1H-Thieno[3,2-d][1,3]oxazine-2,4-dione

thieno[3,2-d]pyrimidine-2,4-diol

Thieno[3,2-d]pyrimidine2,4(1H,3H)-dione

102776

2-chloro-4-Morpholinothieno

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione-2

2,4-Dihydroxythieno[3,2-d]pyrimidine Thieno[3,2-d]pyrimidine-2,4-diol

2-d]pyriMidine-2

1H,2H,3H,4H-thieno[3,2-d]pyriMidine-2,4-dione

Thieno[3,2-d]pyriMidine-2,4-diol(8CI)

2,4-Dihydroxythieno[3,2-D]Pyrimidine(WX619939)

2,4-Dihydr

1,3-Dihydrothiopheno[3,2-d]pyrimidine-2,4-dione ISO 9001：2015 REACH

Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (9CI, ACI)

2,4-Dihydroxythiopheno [3,2-D] pyrimidine

16233-51-5

6233-51-5

API intermediates

Heterocycles

Heterocycle-Pyrimidine series