THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
- Product Name
- THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
- CAS No.
- 53174-98-4
- Chemical Name
- THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE
- Synonyms
- 2-Formylthieno[2,3-b]pyridine;THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE;THIENO[2,3-B]PYRIDINE-2-CARBOXALDEHYDE;Thieno[2,3-b]pyridine-2-carboxaldehyde 97%;Thieno[2,3-b]pyridine-2-carboxaldehyde 97+%
- CBNumber
- CB7729096
- Molecular Formula
- C8H5NOS
- Formula Weight
- 163.2
- MOL File
- 53174-98-4.mol
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Property
- Melting point:
- 142 °C
- Boiling point:
- 320.2±22.0 °C(Predicted)
- Density
- 1.384±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.37±0.40(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 309101
- Product name
- Thieno[2,3-b]pyridine-2-carbaldehyde
- Packaging
- 250.00mg
- Price
- $52
- Updated
- 2026/05/19
- Product number
- 309101
- Product name
- Thieno[2,3-b]pyridine-2-carbaldehyde
- Packaging
- 1.00g
- Price
- $106
- Updated
- 2026/05/19
- Product number
- 309101
- Product name
- Thieno[2,3-b]pyridine-2-carbaldehyde
- Packaging
- 5.00g
- Price
- $367
- Updated
- 2026/05/19
- Product number
- T47760
- Product name
- Thieno[2,3-b]pyridine-2-carbaldehyde
- Purity
- 97%
- Packaging
- 100mg
- Price
- $42
- Updated
- 2026/05/06
- Product number
- T47760
- Product name
- Thieno[2,3-b]pyridine-2-carbaldehyde
- Purity
- 97%
- Packaging
- 250mg
- Price
- $60
- Updated
- 2026/05/06
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Chemical Properties,Usage,Production
Synthesis
272-23-1
68-12-2
53174-98-4
Thieno[2,3-b]pyridine-2-carbaldehyde was synthesized as follows: 1.3 mL (2.08 mmol) of a hexane solution of 0.8 M n-butyllithium was mixed with 0.3 mL (3.3 mmol) of N,N,N',N'-tetramethylethylenediamine under the protection of argon gas and was stirred magnetically for 30 min at room temperature. Subsequently, the reaction mixture was diluted with 5 mL of hexane and cooled in a dry ice-ethanol bath. Under vigorous stirring, 0.23 g (1.7 mmol) of thieno[2,3-b]pyridine was added dropwise (using a small needle syringe). The reaction mixture was stirred in a cooling bath for 7 hours, then slowly warmed to room temperature and continued stirring for 12 hours. After completion of the reaction, the mixture was cooled in an ice bath, 0.15 g (2.1 mmol) of dimethylformamide was added and stirred for 1 hour. Subsequently, 1 mL of ethanol, 3 mL of saturated aqueous ammonium chloride solution and 4 mL of water were added sequentially. The organic layer was separated and the aqueous layer was extracted with chloroform. The organic layers were combined, dried with magnesium sulfate and the solvent was evaporated. The residue was ground with hexane to give 0.18 g (66% yield) of a brown solid with a melting point of 131.5-132.5°C. Recrystallization by ethanol (with the addition of activated charcoal to decolorize the product once) yielded white needle-like crystals. The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.41 (dd, J = 4.5 Hz, 8.1 Hz, 1H), 7.99 (s, 1H), 8.24 (dd, J = 1.8 Hz, 8.1 Hz, 1H), 8.73 (dd, J = 1.8 Hz, 4.5 Hz, 1H), 10.12 (s, 1H).13C NMR (75 MHz, CDCl3) showed: δ 120.7, 131.8, 132.3, 134.0, 143.2, 150.5, 163.8, 185.0. a carbonyl absorption peak at 1682 cm-1 was observed in the IR spectrum (CHCl3, cm-1). The mass spectrum (EI, 70 eV) showed: m/z [%] = 162 [M]+ (100), 134 [M-CO]+ (26). High-resolution mass spectrum (FAB+) calculated value C8H6NOS [M+1] 164.0170, measured value 164.0167.
References
[1] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1952 - 1956
[2] Tetrahedron Letters, 1994, vol. 35, # 7, p. 1011 - 1014
[3] Journal of Heterocyclic Chemistry, 1974, vol. 11, p. 355 - 361
THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Preparation Products And Raw materials
Raw materials
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View Lastest Price from THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE manufacturers
- Product
- THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE 53174-98-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19
- Product
- THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE 53174-98-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19