THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID

Product Name: THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
CAS No.: 59944-76-2
Chemical Name: THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
Synonyms: 2-Carboxythieno[2,3-b]pyridine;HIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID;THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID
CBNumber: CB1185555
Molecular Formula: C8H5NO2S
Formula Weight: 179.2
MOL File: 59944-76-2.mol

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THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Property

Melting point:: 293 °C
Boiling point:: 397.4±22.0 °C(Predicted)
Density: 1.508±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
form: solid
pka: 2.33±0.30(Predicted)
color: Off-white
InChI: InChI=1S/C8H5NO2S/c10-8(11)6-4-5-2-1-3-9-7(5)12-6/h1-4H,(H,10,11)
InChIKey: XGCSHAYMNOFFNA-UHFFFAOYSA-N
SMILES: C12SC(C(O)=O)=CC1=CC=CN=2
CAS DataBase Reference: 59944-76-2

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Safety

Hazard Codes: Xi
HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B585403
Product name: Thieno[2,3-b]pyridine-2-carboxylicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B585403
Product name: Thieno[2,3-b]pyridine-2-carboxylicAcid
Packaging: 500mg
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR15126
Product name: Thieno[2,3-b]pyridine-2-carboxylicacid
Packaging: 250mg
Price: $27
Updated: 2021/12/16

SynQuest Laboratories

Product number: 8H21-1-64
Product name: Thieno[2,3-b]pyridine-2-carboxylic acid
Packaging: 250mg
Price: $29
Updated: 2021/12/16

Apolloscientific

Product number: OR15126
Product name: Thieno[2,3-b]pyridine-2-carboxylicacid
Packaging: 1g
Price: $82
Updated: 2021/12/16

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THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

Thieno[2,3-b]pyridine-2-carboxylic Acid is a useful reagent in study of neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for treatment of Alzheimer’s disease.

Definition

ChEBI: Thieno[2,3-b]pyridine-2-carboxylic acid is a thienopyridine.

Synthesis

154650-88-1

59944-76-2

Methyl thieno[2,3-b]pyridine-2-carboxylate (C101, 0.700 g, 3.63 mmol) was used as a raw material and dissolved in a solvent mixture of methanol (15 mL) and water (3 mL). At room temperature, 2N sodium hydroxide solution (1.82 mL, 3.63 mmol) was added dropwise and the reaction mixture was stirred for 24 hours. Upon completion of the reaction, the mixture was concentrated under vacuum to remove most of the solvent. Subsequently, water (40 mL) was added to dissolve the residue. The resulting solution was acidified to pH 4 with concentrated hydrochloric acid, at which point thieno[2,3-b]pyridine-2-carboxylic acid (C102) precipitated as a white precipitate. The precipitate was collected by filtration to give the target product in 85% yield. The product was analyzed by mass spectrometry (EI) and showed a molecular ion peak m/z of 179 (M+), which is consistent with the theoretical value of the molecular formula C8H5NO2S.

References

[1] Patent: US2003/153595, 2003, A1
[2] Patent: US2003/45540, 2003, A1
[3] Patent: US2012/190674, 2012, A1. Location in patent: Page/Page column 91

THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID Suppliers

Belgium 1 China 72 India 1 United Kingdom 2 United States 6 Global 82

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59944-76-2, THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACIDRelated Search:

THIAZOLO[5,4-B]PYRIDIN-2-AMINE Thieno[3,2-b]thiophene-2-carbonitrile Thieno[2,3-b]pyrazine Thieno[3,2-b]pyridine-2-c... thiazolo[4,5-b]pyridine-2,6-diaMine Thieno[2,3-c]pyridin-7-amine (9CI) THIENO[3,2-D]PYRIMIDIN-4-AMINE PYRIDO[3,2-D][1,3]THIAZOLE-2-THIOL THIENO[2,3-B]PYRIDINE-2-CARBALDEHYDE Thieno[2,3-b]pyridin-5-amine (9CI) thiazolo[4,5-b]pyridine-2(3H)-thione Thieno[2,3-c]pyridine-2-carboxylic acid (9CI) Thieno[3,2-c]pyridine-2-carboxylic acid THIENO(3 2-B)PYRIDIN-7-OL Thieno[2,3-b]pyridine (8CI,9CI) THIENO[3,2-B]PYRIDINE-6-CARBOXYLIC ACID METHYL ESTER Thieno[2,3-b]pyridine-5-carboxylic acid THIENO[2,3-B]THIOPHENE-2-CARBOXYLIC ACID

THIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID

2-Carboxythieno[2,3-b]pyridine

HIENO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID

59944-76-2