DOTA-NOC, DOTA-[Nal3]-octreotide

Product Name: DOTA-NOC, DOTA-[Nal3]-octreotide
CAS No.: 619300-53-7
Chemical Name: DOTA-NOC, DOTA-[Nal3]-octreotide
Synonyms: FC-2154;DOTA-NOC;DOTA-NOC acetate;DOTA-NOC619300-53-7;DOTA-[Nal3]-octreotide;DOTA-NOC, DOTA-[Nal3]-octreotide;L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-Dtryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic(2)-disulfide;L-Cysteinamide, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2-7)-disulfide;L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide;2-[[10-(4-aminobutyl)-7-(1-hydroxyethyl)-13-(1~{H}-indol-3-ylmethyl)-16-(naphthalen-1-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[3-phenyl-2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]propanoyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoic acid
CBNumber: CB11484181
Molecular Formula: C69H92N14O18S2
Formula Weight: 1469.68178
MOL File: 619300-53-7.mol

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DOTA-NOC, DOTA-[Nal3]-octreotide Property

solubility: PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
Sequence: DOTA-{d-Phe}-Cys-{Nal}-{d-Trp}-Lys-Thr-Cys-Thr-ol (Disulfide bridge: Cys2-Cys7)
InChIKey: VMOLIPGHXGTESU-UHFFFAOYSA-N
CAS DataBase Reference: 619300-53-7

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Hazard and Precautionary Statements (GHS)

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DOTA-NOC, DOTA-[Nal3]-octreotide Chemical Properties,Usage,Production

Chemical Properties

Colourless to off-white lyophilised solid

Uses

DOTA-NOC (DOTA-Nal3-octreotide) is a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5. DOTA-NOC can be used for labeling with various radiometals, and development of radiopeptide imaging[1]. DOTA-NOC can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

IC 50

RDC Peptide

References

[1] Wild D, et al. DOTA-NOC, a high-affinity ligand of somatostatin receptor subtypes 2, 3 and 5 for labelling with various radiometals. Eur J Nucl Med Mol Imaging. 2003 Oct;30(10):1338-47. DOI:10.1007/s00259-003-1255-5
[2] JOHAN HYGUM DAM. Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors: Comparison to [68Ga]Ga-DOTA/NOTA-NOC.[J]. Molecules, 2022. DOI: 10.3390/molecules27206818

DOTA-NOC, DOTA-[Nal3]-octreotide Preparation Products And Raw materials

Raw materials

Preparation Products

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DOTA-NOC, DOTA-[Nal3]-octreotide Suppliers

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619300-53-7, DOTA-NOC, DOTA-[Nal3]-octreotideRelated Search:

Octreotide DOTA

DOTA-NOC

DOTA-NOC acetate

L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-Dtryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic(2)-disulfide

DOTA-NOC619300-53-7

DOTA-NOC, DOTA-[Nal3]-octreotide

L-Cysteinamide, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2-7)-disulfide

DOTA-[Nal3]-octreotide

2-[[10-(4-aminobutyl)-7-(1-hydroxyethyl)-13-(1~{H}-indol-3-ylmethyl)-16-(naphthalen-1-ylmethyl)-6,9,12,15,18-pentaoxo-19-[[3-phenyl-2-[[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetyl]amino]propanoyl]amino]-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-hydroxybutanoic acid

FC-2154

L-Cysteinamide, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-3-(1-naphthalenyl)-L-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl]-, cyclic (2→7)-disulfide

619300-53-7

C69H94N14O17S2

C69H92N14O18S2