2-(BENZYLOXY)-6-CHLOROPYRAZINE

Product Name: 2-(BENZYLOXY)-6-CHLOROPYRAZINE
CAS No.: 4774-18-9
Chemical Name: 2-(BENZYLOXY)-6-CHLOROPYRAZINE
Synonyms: 2-(benzyloxy)-6-chloropyraine;2-chloro-6-(phenylmethoxy)Pyrazine;Pyrazine, 2-chloro-6-(phenylmethoxy)-
CBNumber: CB11491279
Molecular Formula: C11H9ClN2O
Formula Weight: 220.65
MOL File: 4774-18-9.mol

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2-(BENZYLOXY)-6-CHLOROPYRAZINE Property

Boiling point:: 321.4±37.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: -1.78±0.10(Predicted)
Appearance: Light yellow to yellow Solid
InChI: InChI=1S/C11H9ClN2O/c12-10-6-13-7-11(14-10)15-8-9-4-2-1-3-5-9/h1-7H,8H2
InChIKey: AOYRICZDNURREY-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(OCC2=CC=CC=C2)=CN=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T327336
Product name: 2-(BENZYLOXY)-6-CHLOROPYRAZINE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1MG
Price: $148
Updated: 2025/07/31

TRC

Product number: B416218
Product name: 2-(Benzyloxy)-6-chloropyrazine
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139678
Product name: 2-(Benzyloxy)-6-chloropyrazine
Packaging: 1g
Price: $111
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139678
Product name: 2-(Benzyloxy)-6-chloropyrazine
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB139678
Product name: 2-(Benzyloxy)-6-chloropyrazine
Packaging: 2g
Price: $193
Updated: 2021/12/16

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2-(BENZYLOXY)-6-CHLOROPYRAZINE Chemical Properties,Usage,Production

Synthesis

4774-14-5

100-51-6

4774-18-9

Benzyl alcohol (0.75 mL, 7.24 mmol) was slowly added dropwise to a cooled suspension of sodium hydride (60%, 300 mg, 7.5 mmol) in THF (20 mL) at 0 °C. After dropwise addition, stirring was continued for 30 min. Subsequently, 2,6-dichloropyrazine (999 mg, 6.71 mmol) was added and the reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl solution. The reaction mixture was extracted with ethyl acetate and the organic phases were combined and washed sequentially with water and brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the crude product 2-benzyloxy-6-chloropyrazine (1.45 g, 5.33 mmol), which could be used in the next reaction without further purification.

References

[1] Synlett, 2014, vol. 25, # 13, p. 1904 - 1908
[2] Patent: US4791127, 1988, A
[3] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 2821-2823

2-(BENZYLOXY)-6-CHLOROPYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(BENZYLOXY)-6-CHLOROPYRAZINE Suppliers

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4774-18-9, 2-(BENZYLOXY)-6-CHLOROPYRAZINERelated Search:

2-chloro-6-[(2-chlorobenzyl)oxy]pyrazine 2-(1,3-benzodioxol-5-ylmethoxy)-6-chloropyrazine 2-chloro-6-[(4-methoxyphenyl)methoxy]pyrazine 2-chloro-6-(1-phenylethoxy)pyrazine 2-(BENZYLOXY)-6-CHLOROPYRAZINE 2-chloro-6-[(3-methoxybenzyl)oxy]pyrazine

2-(benzyloxy)-6-chloropyraine

2-chloro-6-(phenylmethoxy)Pyrazine

Pyrazine, 2-chloro-6-(phenylmethoxy)-

4774-18-9