ChemicalBook > CAS DataBase List > 2-(BENZYLOXY)-6-CHLOROPYRAZINE
2-(BENZYLOXY)-6-CHLOROPYRAZINE
- Product Name
- 2-(BENZYLOXY)-6-CHLOROPYRAZINE
- CAS No.
- 4774-18-9
- Chemical Name
- 2-(BENZYLOXY)-6-CHLOROPYRAZINE
- Synonyms
- 2-(benzyloxy)-6-chloropyraine;2-chloro-6-(phenylmethoxy)Pyrazine;Pyrazine, 2-chloro-6-(phenylmethoxy)-
- CBNumber
- CB11491279
- Molecular Formula
- C11H9ClN2O
- Formula Weight
- 220.65
- MOL File
- 4774-18-9.mol
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2-(BENZYLOXY)-6-CHLOROPYRAZINE Property
- Boiling point:
- 321.4±37.0 °C(Predicted)
- Density
- 1.278±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- pka
- -1.78±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C11H9ClN2O/c12-10-6-13-7-11(14-10)15-8-9-4-2-1-3-5-9/h1-7H,8H2
- InChIKey
- AOYRICZDNURREY-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(OCC2=CC=CC=C2)=CN=C1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- T327336
- Product name
- 2-(BENZYLOXY)-6-CHLOROPYRAZINE
- Purity
- Aldrich<sup>CPR</sup>
- Packaging
- 1MG
- Price
- $148
- Updated
- 2025/07/31
TRC
- Product number
- B416218
- Product name
- 2-(Benzyloxy)-6-chloropyrazine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB139678
- Product name
- 2-(Benzyloxy)-6-chloropyrazine
- Packaging
- 1g
- Price
- $111
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB139678
- Product name
- 2-(Benzyloxy)-6-chloropyrazine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB139678
- Product name
- 2-(Benzyloxy)-6-chloropyrazine
- Packaging
- 2g
- Price
- $193
- Updated
- 2021/12/16
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2-(BENZYLOXY)-6-CHLOROPYRAZINE Chemical Properties,Usage,Production
Synthesis
4774-14-5
100-51-6
4774-18-9
Benzyl alcohol (0.75 mL, 7.24 mmol) was slowly added dropwise to a cooled suspension of sodium hydride (60%, 300 mg, 7.5 mmol) in THF (20 mL) at 0 °C. After dropwise addition, stirring was continued for 30 min. Subsequently, 2,6-dichloropyrazine (999 mg, 6.71 mmol) was added and the reaction mixture was gradually warmed to room temperature and stirred overnight. After completion of the reaction, the reaction was quenched with saturated aqueous NH4Cl solution. The reaction mixture was extracted with ethyl acetate and the organic phases were combined and washed sequentially with water and brine. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the crude product 2-benzyloxy-6-chloropyrazine (1.45 g, 5.33 mmol), which could be used in the next reaction without further purification.
References
[1] Synlett, 2014, vol. 25, # 13, p. 1904 - 1908
[2] Patent: US4791127, 1988, A
[3] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 2821-2823
2-(BENZYLOXY)-6-CHLOROPYRAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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4774-18-9, 2-(BENZYLOXY)-6-CHLOROPYRAZINERelated Search:
2-chloro-6-[(2-chlorobenzyl)oxy]pyrazine
2-(1,3-benzodioxol-5-ylmethoxy)-6-chloropyrazine
2-chloro-6-[(4-methoxyphenyl)methoxy]pyrazine
2-chloro-6-(1-phenylethoxy)pyrazine
2-(BENZYLOXY)-6-CHLOROPYRAZINE
2-chloro-6-[(3-methoxybenzyl)oxy]pyrazine