3-Amino-2-fluorobenzonitrile

Product Name: 3-Amino-2-fluorobenzonitrile
CAS No.: 873697-68-8
Chemical Name: 3-Amino-2-fluorobenzonitrile
Synonyms: 3-AMINO-2-FLUOROBENZONITRILE;2-fluoro-3-aminobenzonitrile;Benzonitrile, 3-amino-2-fluoro-
CBNumber: CB11495914
Molecular Formula: C7H5FN2
Formula Weight: 136.13
MOL File: 873697-68-8.mol

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3-Amino-2-fluorobenzonitrile Property

Boiling point:: 270.3±20.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
pka: 1.40±0.10(Predicted)
Appearance: Light brown to brown Solid

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Safety

HazardClass: IRRITANT
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P311Call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: A898598
Product name: 3-Amino-2-fluorobenzonitrile
Packaging: 2.5g
Price: $310
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA165046
Product name: 3-Amino-2-fluorobenzonitrile
Packaging: 500mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA165046
Product name: 3-Amino-2-fluorobenzonitrile
Packaging: 1g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: 3821AC
Product name: 3-Amino-2-fluorobenzonitrile
Packaging: 1g
Price: $89
Updated: 2021/12/16

Matrix Scientific

Product number: 024815
Product name: 3-Amino-2-fluorobenzonitrile
Purity: 96%
Packaging: 1g
Price: $98
Updated: 2021/12/16

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3-Amino-2-fluorobenzonitrile Chemical Properties,Usage,Production

Uses

3-Amino-2-fluorobenzonitrile is a derivative of fluorobenzonitrile. This compound is used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

2106-04-9

143-33-9

873697-68-8

Step 1: To a round-bottomed flask under nitrogen protection were added 1 eq. of 3-chloro-2-fluoroaniline (3A), 1.5 M of 1-methyl-2-pyrrolidinone (NMP, as 3A), 2.2 eq. of sodium cyanide, and 1.35 eq. of nickel (II) bromide. The concentration of the reaction solution was diluted to half of the original concentration by supplementing with NMP, slowly warmed to 200 ± 5 °C and the reaction was stirred for 4 days under nitrogen atmosphere. After completion of the reaction, the mixture was cooled to room temperature. The reaction mixture was diluted with 30 times volume of tert-butyl methyl ether (MTBE) and filtered through diatomaceous earth. The diatomaceous earth pad was subsequently washed with 10 times volume of MTBE. The organic phase was washed sequentially with 40x volume of brine, 2 x 40x volume of water and 40x volume of brine. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give a brown solid. The solid was dried at 40 °C under vacuum at -30 inches Hg for 8 hours to give the target compound 3B in 71% yield.

References

[1] Patent: US2006/14761, 2006, A1. Location in patent: Page/Page column 32
[2] Patent: WO2007/75377, 2007, A2. Location in patent: Page/Page column 58
[3] Patent: WO2007/70626, 2007, A2. Location in patent: Page/Page column 45
[4] Patent: WO2007/70683, 2007, A2. Location in patent: Page/Page column 88
[5] Patent: WO2007/78839, 2007, A2. Location in patent: Page/Page column 46

3-Amino-2-fluorobenzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Amino-2-fluorobenzonitrile Suppliers

China 80 Germany 1 India 1 United Kingdom 2 United States 5 Global 89

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View Lastest Price from 3-Amino-2-fluorobenzonitrile manufacturers

Career Henan Chemical Co

Product: 3-AMINO-2-FLUOROBENZONITRILE 873697-68-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2018-12-17

873697-68-8, 3-Amino-2-fluorobenzonitrileRelated Search:

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3-AMINO-2-FLUOROBENZONITRILE

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2-fluoro-3-aminobenzonitrile

873697-68-8