3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- Product Name
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- CAS No.
- 350997-39-6
- Chemical Name
- 3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE
- Synonyms
- OGG1-IN-08;OGG1-IN-O8;O8 OGG1 Inhibitor;OGG1 Inhibitor O8;OGG1 Inhibitor O8 >=98% (HPLC);3,4-Dichlorobenzo[b]thiophene-2-carbohydrazide;3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE;Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide;Inhibitor,inhibit,OGG1,FapyGua,OGG1IN08,glycosylase,AP site,OGG1 IN 08,lyase,OGG-1-IN-08
- CBNumber
- CB11499417
- Molecular Formula
- C9H6Cl2N2OS
- Formula Weight
- 261.13
- MOL File
- 350997-39-6.mol
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Property
- Density
- 1.587±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 5mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL
- form
- powder
- pka
- 11.75±0.30(Predicted)
- color
- white to beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1697
- Product name
- OGG1 Inhibitor O8
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $105
- Updated
- 2023/06/20
- Product number
- SML1697
- Product name
- OGG1 Inhibitor O8
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $424
- Updated
- 2023/06/20
- Product number
- 29769
- Product name
- OGG1-IN-O8
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 29769
- Product name
- OGG1-IN-O8
- Packaging
- 25mg
- Price
- $330
- Updated
- 2024/03/01
- Product number
- 29769
- Product name
- OGG1-IN-O8
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Chemical Properties,Usage,Production
Uses
O8 OGG1 Inhibitor is potent and selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 0.2 μM in a gel based assay). Exhibits > 200-fold selectivity for OGG1 over other DNA glycosylases, NEIL1 and NTH1.
General Description
Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.
Biochem/physiol Actions
OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.
storage
Store at +4°C
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-DICHLORO-1-BENZOTHIOPHENE-2-CARBOHYDRAZIDE Suppliers
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58