3,5-Difluoro-4-pyridinecarboxaldehyde
Uses- Product Name
- 3,5-Difluoro-4-pyridinecarboxaldehyde
- CAS No.
- 870234-98-3
- Chemical Name
- 3,5-Difluoro-4-pyridinecarboxaldehyde
- Synonyms
- 2,6-difluoroisonicotinaldehyde;3,5-Difluoroisonicotinaldehyde 98%;3,5-Difluoro-4-pyridinecarboxaldehyde;4-Pyridinecarboxaldehyde, 3,5-difluoro-;3,5-difluoropyridine-4-carbaldehyde - [D87647];(5-fluoro-4-(methylsulfonyl)pyridin-3-yl)boronic acid;3,5-Difluoro-4-pyridinecarboxaldehyde ISO 9001：2015 REACH;3,5-Difluoropyridine-4-carboxaldehyde, 3,5-Difluoro-4-formylpyridine;3,5-Difluoropyridine-4-carboxaldehyde 3,5-Difluoro-4-pyridinecarboxaldehyde
- CBNumber
- CB11501367
- Molecular Formula
- C6H3F2NO
- Formula Weight
- 143.09
- MOL File
- 870234-98-3.mol
3,5-Difluoro-4-pyridinecarboxaldehyde Property
- Melting point:
- 51-52℃
- Boiling point:
- 169℃
- Density
- 1.392
- Flash point:
- 56℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.60±0.28(Predicted)
- Appearance
- Light yellow to yellow Solid
- InChI
- InChI=1S/C6H3F2NO/c7-5-1-9-2-6(8)4(5)3-10/h1-3H
- InChIKey
- RLAOKDGTZKSUJB-UHFFFAOYSA-N
- SMILES
- C1=NC=C(F)C(C=O)=C1F
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D234980
- Product name
- 3,5-Difluoroisonicotinaldehyde
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- Y4412
- Product name
- 3,5-Difluoropyridine-4-carbaldehyde
- Packaging
- 1g
- Price
- $251
- Updated
- 2021/12/16
- Product number
- D1694
- Product name
- 3,5-Difluoro-4-formylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- FD32269
- Product name
- 3,5-Difluoro-4-pyridinecarboxaldehyde
- Packaging
- 1g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- HCH0004101
- Product name
- 3,5-DIFLUORO PYRIDINE-4-CARBOXALDEHYDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $553
- Updated
- 2021/12/16
3,5-Difluoro-4-pyridinecarboxaldehyde Chemical Properties,Usage,Production
Uses
3,5-Difluoropyridine-4-carboxaldehyde is an aldehyde organic compound that can be used as a pharmaceutical intermediate.
Synthesis
107-31-3
71902-33-5
870234-98-3
General procedure for the synthesis of 3,5-difluoropyridine-4-carbaldehyde from methyl formate and 3,5-difluoropyridine: Preparation of Example 10: N-[(3,5-difluoro-4-pyridinyl)methyl]-2-(trifluoromethyl)pyridine-3-carboxamide (Compound A126) Step 1: Synthesis of 3,5-difluoropyridine-4-carbaldehyde A 2M solution of LDA (47.792 mL, 95.58 mmol) was diluted with 50 mL of THF at 0°C and cooled to -78°C. Subsequently, a 100 mL THF solution of 3,5-difluoropyridine (7.886 mL, 86.89 mmol) was added dropwise, keeping the temperature lower than -70°C (the dropwise addition process was controlled to be completed within 20 min). The reaction mixture formed a yellow suspension. Stirring was continued at -78°C for 3 hours. Then, 25 mL of THF solution of methyl formate (10.8 mL, 173.79 mmol) was added and the reaction mixture was transformed into a light yellow solution and stirred at -75°C for 45 minutes. The reaction mixture was transferred by cannula to 100 mL of stirred saturated aqueous NaHCO3 solution, maintained at about 0°C. The solution was extracted with EtOAc, the organic phases were combined and washed with brine and dried with 1N HCl. The solvent was evaporated at 165 mbar, 30°C to give 36.7 g of yellow liquid crude product. The crude product was purified by fast chromatography (eluent: CH2Cl2) to give a light yellow oil (7.85 g), which was crystallized after standing. 1H-NMR (CDCl3) data: δ 10.4 (s, 1H), 8.57 (s, 2H).
References
[1] Patent: US2014/128386, 2014, A1. Location in patent: Paragraph 1410; 1411; 1412; 1413; 1414
[2] Patent: US2017/57954, 2017, A1. Location in patent: Paragraph 0630; 0631; 0632; 0633; 0634
[3] Patent: US2009/286800, 2009, A1. Location in patent: Page/Page column 107-108
[4] Patent: WO2013/64521, 2013, A1. Location in patent: Page/Page column 112
[5] Patent: US2017/217954, 2017, A1
3,5-Difluoro-4-pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
3,5-Difluoro-4-pyridinecarboxaldehyde Suppliers
- Tel
- --
- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
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View Lastest Price from 3,5-Difluoro-4-pyridinecarboxaldehyde manufacturers
- Product
- 3,5-Difluoro-4-pyridinecarboxaldehyde 870234-98-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 3,5-Difluoro-4-pyridinecarboxaldehyde 870234-98-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2019-12-24