LOXOPROFEN SODIUM SALT
- Product Name
- LOXOPROFEN SODIUM SALT
- CAS No.
- 226721-96-6
- Chemical Name
- LOXOPROFEN SODIUM SALT
- Synonyms
- LOXOPROFEN SODIUM SALT;Loxoprofen Impurity 72;LoxoprofenSodiumSaltDihydrate>Loxoprofen SodiuM Salt Dihydrate;2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionic Acid Sodium Salt
- CBNumber
- CB11506115
- Molecular Formula
- C15H21NaO5
- Formula Weight
- 304.31401
- MOL File
- 226721-96-6.mol
LOXOPROFEN SODIUM SALT Property
- Melting point:
- 198°C(dec.)(lit.)
- solubility
- Methanol (Sparingly), Water (Slightly)
- form
- powder to crystal
- color
- White to Almost white
- Merck
- 14,5589
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 226721-96-6
Safety
- RIDADR
- UN 2811 6.1/PG III
- RTECS
- CY1678845
- HS Code
- 2918.30.3000
- HazardClass
- 6.1
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L0252
- Product name
- Loxoprofen Sodium Salt Dihydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $61
- Updated
- 2026/03/19
- Product number
- L0252
- Product name
- Loxoprofen Sodium Salt Dihydrate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $204
- Updated
- 2026/03/19
- Product number
- L469378
- Product name
- LoxoprofenSodiumDihydrate
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- L469378
- Product name
- LoxoprofenSodiumDihydrate
- Packaging
- 100mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 38006
- Product name
- Loxoprofensodiumsaltdihydrate,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 5G
- Price
- $90.72
- Updated
- 2021/12/16
LOXOPROFEN SODIUM SALT Chemical Properties,Usage,Production
Uses
Loxoprofen sodium dihydrate is a non-steroidal, orally active anti-inflammatory agent with analgesic and anti-pyretic properties. Loxoprofen sodium dihydrate is a nonselective COX inhibitor with IC50s of 6.5 and 13.5 μM for COX-1 and COX-2, respectively. Loxoprofen sodium dihydrate can reduce atherosclerosis and shows antitumor activity[1][2][3][4].
Definition
ChEBI: Loxoprofen sodium hydrate is a hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted into its active trans-alcohol metabolite following oral administration. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor and an antipyretic. It contains a loxoprofen sodium.
in vivo
Loxoprofen sodium (4 mg/kg/day; p.o.; 1 or 8 weeks) dihydrate reduces atherosclerosis in mice by reducing inflammation[3]. Loxoprofen sodium (60 μg/mL; p.o.; 24 days) dihydrate suppresses mouse tumor growth by inhibiting VEGF[4].
| Animal Model: | ApoE-/- mice (C57BL/6J-Apoetm1Unc) with high-fat diet (0.2% cholesterol, 21% saturated fat) from 8 to 16 weeks of age[3] |
| Dosage: | 4 mg/kg/day in drinking water |
| Administration: | Oral dosing from 8 to 16 weeks of age or from 15 to 16 weeks of age |
| Result: | Inhibited platelet thromboxane production and platelet aggregation. Reduced extent of atherosclerosis. Suppressed the production of PGE2, TxB2 and PGI2. |
| Animal Model: | 6-week-old male C57BL/6 and BDF1 mice, 100 μL suspensions (2 × 106 cells/mL) of LLC cells and KLN205 cells were injected subcutaneously into C57BL/6 and BDF1 mice, respectively[4]. |
| Dosage: | 60 μg/mL |
| Administration: | Oral dosing in drinking water, every day for 24 days |
| Result: | Suppressed tumor growth and angiogenesis, suppressed expression of VEGF in mice with LLC tumor, inhibited tubular formation of HUVECs. |
IC 50
COX-1: 6.5 μM (IC50, in human whole blood); COX-2: 13.5 μM (IC50, in human whole blood)
References
[1] Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203. DOI:10.1016/j.bmcl.2003.12.047
[2] Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16. DOI:10.3390/pharmaceutics11090479
[3] Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47. DOI:10.3164/jcbn.10-33
[4] Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70. DOI:10.1080/0891060310002258
LOXOPROFEN SODIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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