Loxoprofen sodium
- Product Name
- Loxoprofen sodium
- CAS No.
- 80382-23-6
- Chemical Name
- Loxoprofen sodium
- Synonyms
- Loxoprofen sodiuM hydrate;LOXOPROFEN NA;LXP;Loxonin;loxoprofern sodium;Loxoprofen Sodium impurity;cs-600;Unastin;Dipyridame;LOXOPROFEN SODIUM
- CBNumber
- CB5138100
- Molecular Formula
- C15H19NaO3
- Formula Weight
- 270.3
- MOL File
- 80382-23-6.mol
Loxoprofen sodium Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- DMSO: soluble
- form
- A solid
- color
- White to off-white
- InChI
- InChI=1S/C15H18O3.Na.H/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;
- InChIKey
- ALZXNWUYLUBHJL-UHFFFAOYSA-N
- SMILES
- C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1.[NaH]
- CAS DataBase Reference
- 80382-23-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L472900
- Product name
- LoxoprofenSodium(Mixtureofdiastereomers)
- Packaging
- 25g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- L472900
- Product name
- LoxoprofenSodium(Mixtureofdiastereomers)
- Packaging
- 100g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- 015693
- Product name
- Loxoprofen Sodium
- Packaging
- 25mg
- Price
- $446
- Updated
- 2021/12/16
- Product number
- 18682
- Product name
- LoxoprofenSodium
- Packaging
- 5G
- Price
- $490
- Updated
- 2021/12/16
- Product number
- API0003221
- Product name
- LOXOPROFEN SODIUM
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $500
- Updated
- 2021/12/16
Loxoprofen sodium Chemical Properties,Usage,Production
Description
Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity.
Originator
Sankyo (Japan)
Uses
anti-inflammatory
Definition
ChEBI: A hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.
brand name
LOXONIN
Mechanism of action
As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.
Side effects
Adverse effects include anorexia, nausea, vomiting, bleeding, anemia, diarrhea, and constipation.
Synthesis
68767-14-6
80382-23-6
General procedure for the synthesis of sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionate from 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid: 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid and methanol were added into a round-bottomed flask, and 1 equivalent of aqueous sodium hydroxide was added to the above solution drop by drop, and the reaction was stirred for 1 hour at room temperature. Upon completion of the reaction, a decompression distillation was carried out at 50-55°C to remove the solvent. Subsequently, a 5% aqueous solution of ethyl acetate was added to the residue, heated until dissolved and then slowly cooled to room temperature. Crystallization was induced by the addition of crystal seeds during cooling and stirring was continued for 5-6 hours at 0-5°C until a suspension was formed. Finally, the solid was collected by filtration to give loxoprofen sodium dihydrate in 95% yield and 99.1% HPLC purity.
References
[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7879 - 7882
[2] Patent: CN107176942, 2017, A. Location in patent: Paragraph 0067; 0068; 0069
[3] Patent: CN108440274, 2018, A. Location in patent: Paragraph 0076; 0077; 0078; 0079; 0080
Loxoprofen sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Loxoprofen sodium Suppliers
- Tel
- 18672616696
- 229092275@qq.com
- Country
- China
- ProdList
- 706
- Advantage
- 58
- Tel
- 17710328343
- 3004011422@qq.com
- Country
- China
- ProdList
- 2878
- Advantage
- 58
- Tel
- 13217229939
- 773651767@qq.com
- Country
- China
- ProdList
- 4535
- Advantage
- 58
- Tel
- 13626726938
- 15952452933@163.cn
- Country
- China
- ProdList
- 4109
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6003
- Advantage
- 61
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2123
- Advantage
- 70
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
View Lastest Price from Loxoprofen sodium manufacturers
- Product
- Loxoprofen sodium 80382-23-6
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-14
- Product
- Loxoprofen sodium 80382-23-6
- Price
- US $0.00-0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 1000kg
- Release date
- 2021-09-10
- Product
- Loxoprofen sodium 80382-23-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06