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Loxoprofen sodium

Product Name
Loxoprofen sodium
CAS No.
80382-23-6
Chemical Name
Loxoprofen sodium
Synonyms
Loxoprofen sodiuM hydrate;LOXOPROFEN NA;LXP;Loxonin;loxoprofern sodium;Loxoprofen Sodium impurity;cs-600;Unastin;Dipyridame;LOXOPROFEN SODIUM
CBNumber
CB5138100
Molecular Formula
C15H19NaO3
Formula Weight
270.3
MOL File
80382-23-6.mol
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Loxoprofen sodium Property

storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO: soluble
form 
A solid
color 
White to off-white
InChI
InChI=1S/C15H18O3.Na.H/c1-10(15(17)18)12-7-5-11(6-8-12)9-13-3-2-4-14(13)16;;/h5-8,10,13H,2-4,9H2,1H3,(H,17,18);;
InChIKey
ALZXNWUYLUBHJL-UHFFFAOYSA-N
SMILES
C(C1CCCC1=O)C1C=CC(C(C)C(=O)O)=CC=1.[NaH]
CAS DataBase Reference
80382-23-6(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
L472900
Product name
LoxoprofenSodium(Mixtureofdiastereomers)
Packaging
25g
Price
$140
Updated
2021/12/16
TRC
Product number
L472900
Product name
LoxoprofenSodium(Mixtureofdiastereomers)
Packaging
100g
Price
$275
Updated
2021/12/16
Usbiological
Product number
015693
Product name
Loxoprofen Sodium
Packaging
25mg
Price
$446
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
18682
Product name
LoxoprofenSodium
Packaging
5G
Price
$490
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0003221
Product name
LOXOPROFEN SODIUM
Purity
95.00%
Packaging
5G
Price
$500
Updated
2021/12/16
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Loxoprofen sodium Chemical Properties,Usage,Production

Description

Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity.

Originator

Sankyo (Japan)

Uses

anti-inflammatory

Definition

ChEBI: A hydrate that is the dihydrate form of loxoprofen sodium. The parent acid, loxoprofen, is a prodrug that is rapidly converted to its active trans-alcohol metabolite following oral administration.

brand name

LOXONIN

Mechanism of action

As most NSAIDs, loxoprofen is a non-selective cyclooxygenase inhibitor, and works by reducing the synthesis of prostaglandins from arachidonic acid.

Side effects

Adverse effects include anorexia, nausea, vomiting, bleeding, anemia, diarrhea, and constipation.

Synthesis

68767-14-6

80382-23-6

General procedure for the synthesis of sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionate from 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid: 2-(4-((2-oxocyclopentyl)methyl)phenyl)propionic acid and methanol were added into a round-bottomed flask, and 1 equivalent of aqueous sodium hydroxide was added to the above solution drop by drop, and the reaction was stirred for 1 hour at room temperature. Upon completion of the reaction, a decompression distillation was carried out at 50-55°C to remove the solvent. Subsequently, a 5% aqueous solution of ethyl acetate was added to the residue, heated until dissolved and then slowly cooled to room temperature. Crystallization was induced by the addition of crystal seeds during cooling and stirring was continued for 5-6 hours at 0-5°C until a suspension was formed. Finally, the solid was collected by filtration to give loxoprofen sodium dihydrate in 95% yield and 99.1% HPLC purity.

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 21, p. 7879 - 7882
[2] Patent: CN107176942, 2017, A. Location in patent: Paragraph 0067; 0068; 0069
[3] Patent: CN108440274, 2018, A. Location in patent: Paragraph 0076; 0077; 0078; 0079; 0080

Loxoprofen sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Loxoprofen sodium manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
Loxoprofen sodium 80382-23-6
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Loxoprofen sodium 80382-23-6
Price
US $0.00-0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-09-10
Hebei Chuanghai Biotechnology Co., Ltd
Product
Loxoprofen sodium 80382-23-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-06

80382-23-6, Loxoprofen sodiumRelated Search:

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  • 80382-23-6