(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Product Name
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- CAS No.
- 461432-22-4
- Chemical Name
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Synonyms
- Dapagliflozin-15;Dapagliflozin iMpurity A;Dapagliflozin Impurity 18;Dapagliflozin Bromomethanone;Dapagliflozin Intermediate I;5-broMo-2-chloro-4'-ethoxybenzophenone;(5-broMo-2-chlorophenyl)(4-ethoxyphenyl)-;5-bromo-2-chloro-4’-ethoxydiphenylmethanone;5-Bromo-2-ChIorophenyI 4-Ethoxypheny Methanone;(5-Bromo-2-chlorophenyl)(4-oxophenyl)methanone
- CBNumber
- CB11509853
- Molecular Formula
- C15H12BrClO2
- Formula Weight
- 339.61
- MOL File
- 461432-22-4.mol
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Property
- Boiling point:
- 439.2±40.0 °C(Predicted)
- Density
- 1.437
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Low-Melting Solid
- color
- Off-White to Pale Yellow
- InChI
- InChI=1S/C15H12BrClO2/c1-2-19-12-6-3-10(4-7-12)15(18)13-9-11(16)5-8-14(13)17/h3-9H,2H2,1H3
- InChIKey
- OEURLNJEQCLGPS-UHFFFAOYSA-N
- SMILES
- C(C1=CC(Br)=CC=C1Cl)(C1=CC=C(OCC)C=C1)=O
- CAS DataBase Reference
- 461432-22-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B680542
- Product name
- (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB31208
- Product name
- (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-B0022
- Product name
- (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Purity
- 99.57%
- Packaging
- 10g
- Price
- $53
- Updated
- 2021/12/16
- Product number
- FB31208
- Product name
- (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-B0022
- Product name
- (5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone
- Purity
- 99.57%
- Packaging
- 25g
- Price
- $109
- Updated
- 2021/12/16
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Chemical Properties,Usage,Production
Uses
(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone is an intermediate used in the improved synthesis of Dapagliflozin, a novel selective sodium-glucose co-transporter type II (SGLT2) inhibitor.
Synthesis
21900-52-7
103-73-1
461432-22-4
Under the protection of nitrogen, 2.1 g of tert-butyldimethylchlorosilane prepared in step 1) was mixed with 5-bromo-2-chlorobenzoyl chloride in anhydrous dichloromethane and stirred for 30 min at 0 to 10 °C. Subsequently, 1.2 mol of phenethyl ether and 1.1 mol of ferric chloride were sequentially added to the reaction system, and the reaction temperature was maintained at 14.7 °C, and the reaction continued to be stirred for 5 hours. After completion of the reaction, the reaction mixture was quenched by pouring it into ice water, extracted with dichloromethane, the organic phase was washed with water, and 31 g of 5-bromo-2-chloro-4'-ethoxy benzophenone (intermediate of dagliflozin) was obtained after concentration in 91.4% yield and 99.49% purity.
References
[1] Patent: CN107200683, 2017, A. Location in patent: Paragraph 0029; 0035; 0039; 0043; 0047
[2] Patent: CN107417515, 2017, A. Location in patent: Paragraph 0030; 0032; 0034; 0036; 0038; 0040
[3] Patent: CN103739581, 2016, B. Location in patent: Paragraph 0228; 0229
[4] Patent: WO2012/25857, 2012, A1. Location in patent: Page/Page column 20
[5] Patent: CN106316803, 2017, A. Location in patent: Paragraph 0014
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Preparation Products And Raw materials
Raw materials
Preparation Products
(5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone Suppliers
- Tel
- 0512-87815088 18015562287
- Fax
- 0512-69233866
- xmwang@xiaolitech.com
- Country
- China
- ProdList
- 66
- Advantage
- 58
- Tel
- 0598-5501589 15392323620
- zmy@welikepharma.com
- Country
- China
- ProdList
- 93
- Advantage
- 58
- Tel
- 17185714011
- 3506894070@qq.com
- Country
- China
- ProdList
- 117
- Advantage
- 58
- Tel
- 0531-82375892 15553111391
- 3276840968@qq.com
- Country
- China
- ProdList
- 301
- Advantage
- 58
- Tel
- 010-68862197 13810598707
- Fax
- 010-68882204
- sales@huikangchem.com
- Country
- China
- ProdList
- 109
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
View Lastest Price from (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone manufacturers
- Product
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 800KG
- Release date
- 2025-03-11
- Product
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4
- Price
- US $200.00-150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg per month
- Release date
- 2023-09-28
- Product
- (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 461432-22-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-05