4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- Product Name
- 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- CAS No.
- 461432-23-5
- Chemical Name
- 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- Synonyms
- 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene;Dapagliflozin Bromo impurity;Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-;Dapagliflozin-13;Dapaglifozin DAP Bromo;5-broMo-2-chloro-4’Dapagliflozin Impurity 15;4-(Dibenzofuranyl)boronic;Dapagliflozin Impurity 82;Dapagliflozin Intermediate 1
- CBNumber
- CB71456759
- Molecular Formula
- C15H14BrClO
- Formula Weight
- 325.63
- MOL File
- 461432-23-5.mol
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Property
- Boiling point:
- 393.0±32.0 °C(Predicted)
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Low-Melting Solid
- color
- White to Off-White
- Stability:
- Stable under recommended storage conditions., Stable Under Recommended Storage C
- InChI
- InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3
- InChIKey
- ZUNCHZBITMUSRD-UHFFFAOYSA-N
- SMILES
- C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1
Safety
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B682175
- Product name
- 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- FB76075
- Product name
- 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- Packaging
- 50g
- Price
- $500
- Updated
- 2021/12/16
- Product number
- CS-B0023
- Product name
- 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- Purity
- 98.57%
- Packaging
- 100g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- FB76075
- Product name
- 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
- Packaging
- 10g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 083813
- Product name
- 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
- Purity
- 97%
- Packaging
- 5g
- Price
- $242
- Updated
- 2021/12/16
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Chemical Properties,Usage,Production
Uses
5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.
Synthesis
Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene manufacturers
- Product
- 5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5
- Price
- US $999.00-666.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-20
- Product
- 5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 500
- Release date
- 2024-03-20
- Product
- 5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5
- Price
- US $100.00-70.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-16