ChemicalBook > CAS DataBase List > 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

Product Name
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
CAS No.
461432-23-5
Chemical Name
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Synonyms
4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene;Dapagliflozin Bromo impurity;Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-;Dapagliflozin-13;Dapaglifozin DAP Bromo;5-broMo-2-chloro-4’Dapagliflozin Impurity 15;4-(Dibenzofuranyl)boronic;Dapagliflozin Impurity 82;Dapagliflozin Intermediate 1
CBNumber
CB71456759
Molecular Formula
C15H14BrClO
Formula Weight
325.63
MOL File
461432-23-5.mol
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4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Property

Boiling point:
393.0±32.0 °C(Predicted)
Density 
1.371±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Low-Melting Solid
color 
White to Off-White
Stability:
Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI
InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3
InChIKey
ZUNCHZBITMUSRD-UHFFFAOYSA-N
SMILES
C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1
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Safety

HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B682175
Product name
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Packaging
1g
Price
$460
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB76075
Product name
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Packaging
50g
Price
$500
Updated
2021/12/16
ChemScene
Product number
CS-B0023
Product name
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Purity
98.57%
Packaging
100g
Price
$158
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB76075
Product name
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Packaging
10g
Price
$180
Updated
2021/12/16
Matrix Scientific
Product number
083813
Product name
4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
Purity
97%
Packaging
5g
Price
$242
Updated
2021/12/16
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4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Chemical Properties,Usage,Production

Uses

5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.

Synthesis

Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene manufacturers

Hebei Mujin Biotechnology Co.,Ltd
Product
5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-03-01
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5
Price
US $999.00-666.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-20
hebei hongtan Biotechnology Co., Ltd
Product
5-bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5
Price
US $80.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
500
Release date
2024-03-20

461432-23-5, 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzeneRelated Search:

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 4-(5-broMo-2-chlorobenzyl)phenol 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene Empagliflozin Canagliflozin heMihydrate PF-04971729 Ipragliflozin Canagliflozin 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Donepezil 1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone (5-bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone 4-BROMO-1-CHLORO-2-ETHYLBENZENE 5-bromo-2-chloro-4’-ethoxydiphenylmethane

  • 5-bromo-2-chloro-4’-ethoxydiphenylmethane
  • Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-
  • 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
  • Dapagliflozin Intermediate 1
  • 4-broMo-1-chloro-2-[(4-ethoxyphenyl)Methyl]-
  • 2-(4-Methoxybenzyl)-4-broMo-1-chlorobenzene
  • 1-(5-broMo-2-chlorobenzyl)-4-ethoxybenzene
  • Dapagliflozin-13
  • Dapagliflozin Bromo impurity
  • 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene
  • 5-broMo-2-chloro-4&rsquo
  • Dapagliflozin Intermediate II
  • Dapagliflozin Intermediate 2
  • 5-bromo-2-chloro-4'-ethoxydiphenylmethane###461432-23-5
  • (5-bromo-2-chlorobenzyl)-4-ethoxybenzene
  • 4-(5-Brom-2-chlorbenzyl)phenyl-ethylether
  • Dapagliflozin Impurity 15
  • 4-(Dibenzofuranyl)boronic
  • 4-(5-Bromo-2-chlorobenzy)phenylethyl ester
  • Dapagliflozin Impurity 82
  • 4-Bromo-1-chloro-2-(4-ethoxybenzyl)
  • Dapagliflozin Despyranose Bromo Impurity
  • 4-Brom-1-chlor-2-(4-ethoxybenzyl)benzol
  • 5-bromo-2-chloro-4’-ethoxydiphenylmethane ISO 9001：2015 REACH
  • 4-(3-((1-ethoxyethoxy)methyl)-4-bromophenoxy)benzonitrile
  • Supply 5-bromo-2-chloro-4'-ethoxydiphenylmethane
  • Dapaglifozin DAP Bromo
  • 5-bromo-2-chloro-4-ethoxydiphenylmethaneQ: What is 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the CAS Number of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the storage condition of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What are the applications of 5-bromo-2-chloro-4-ethoxydiphenylmethane
  • Dapagliflozin Intermediate/ 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane
  • 4-(5- bromo -2- chlorobenzyl) phenethyl ether
  • 5-Bromo-2-chIoro-4’-ethoxydiphenyImethane
  • 4-Bromo-1-ChIoro 2-4-EthoxybenzyI-Benzene
  • 4-bromo-l-chloro-2-(4-ethoxybenzyl)benzene
  • 2-(4-ethoxybenzyl)-4-bromo-1-chloro benzene
  • 5-bromo-2-chloro-4’-ethoxydiphenylmethane, Or 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
  • (5-Bromo-2-chlorobenzyl)phenyl ethyl ether
  • 5-bromo-2-chloro-4'-ethoxydiphenylmethane
  • 6-bromo-2-chloro-4’-ethoxydiphenylmethane
  • 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
  • 5-bromo-2-chloro-4’-ethoxydiphenylmethan
  • 461432-23-5
  • 61432-23-5
  • 100134-06-9
  • 9461432-23-5
  • C15H14BrClO
  • Halides
  • Phenyls & Phenyl-Het
  • 461432-23-5
  • ADVANCED INT.