2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
Description Uses Reference- Product Name
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- CAS No.
- 32384-65-9
- Chemical Name
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- Synonyms
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone;Dagliptin Impurity;oxy)-6-((triMethyL;Cagliflozin Impurity 9;Englitazinintermediate;Dapagliflozin Impurity 12;Canagliflozin Related Impurity 9;(3R,4S,5R,6R)-3,4,5-tris(triMethyL;Canagliflozin Impurity 9(Dagelin impurity 11)
- CBNumber
- CB32610563
- Molecular Formula
- C18H42O6Si4
- Formula Weight
- 466.87
- MOL File
- 32384-65-9.mol
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Property
- Boiling point:
- 417℃
- Density
- 0.97
- Flash point:
- 171℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Oil
- color
- Colourless to Pale Yellow
- Stability:
- Moisture Sensitive
Safety
- HS Code
- 2931900090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- T279540
- Product name
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- Packaging
- 5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- T279540
- Product name
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- Packaging
- 50g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- MT08101
- Product name
- 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone
- Packaging
- 100g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-M2269
- Product name
- (3R,4S,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
- Purity
- >97.0%
- Packaging
- 500g
- Price
- $321
- Updated
- 2021/12/16
- Product number
- MT08101
- Product name
- 2,3,4,6-Tetra-O-trimethylsilyl-D-glucono-1,5-lactone
- Packaging
- 250g
- Price
- $375
- Updated
- 2021/12/16
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Chemical Properties,Usage,Production
Description
It is usually used as the intermediate and raw material in the chemistry synthesis and pharmaceutical industry. Especially, this chemical has been widely used in the design and synthesis of sodium-glucose transporter inhibitors.1 For example, this substance can be employed as raw material in the preparation of (1s)-1,5-anhydro-1-c-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol, which is commonly known as Dapagliflozin that act as the sodium dependent glucose transporters for treating type 2 diabetes.2 Moreover, it can also function as the intermediate for synthesizing empagliflozin, which is a novel and selective sodium glucose co-transporter-2 inhibitor.3 In addition, canagliflozin, another sodium glucose co-transporter-2 inhibitor, can be obtained by utilizing this substance as the intermediate.4
Uses
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.
Reference
- Guo, C.; Hu, M.; DeOrazio, R. J.; Usyatinsky, A.; Fitzpatrick, K.; Zhang, Z. J.; Maeng, J. H.; Kitchen, D. B.; Tom, S.; Luche, M.; Khmelnitsky, Y.; Mhyre, A. J.; Guzzo, P. R.; Liu, S., The design and synthesis of novel SGLT2 inhibitors: C-glycosides with benzyltriazolopyridinone and phenylhydantoin as the aglycone moieties. Bioorg. Med. Chem. 2014, 22, 3414-3422.
- S Thirumalai Rajan; Eswaraiah, S., Process for the preparation of (1S)-1,5-anhydro-1-C-[4-chloro-3-[(4-ethoxylphenyl)methyl]phenyl]-D-glucitol and its solvate thereof. US Patent 2015, WO 2015/132803 A2.
- Hrapchak, M.; Latli, B.; Wang, X. J.; Lee, H.; Campbell, S.; Song, J. J.; Senanayake, C. H., Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. J. Label. Compd. Radiopharm. 2014, 57, 687-694.
- Nomura, S.; Sakamaki, S.; Hongu, M.; Kawanishi, E.; Koga, Y.; Sakamoto, T.; Yamamoto, Y.; Ueta, K.; Kimata, H.; Nakayama, K.; Tsuda-Tsukimoto, M., Discovery of Canagliflozin, a Novel C-Glucoside with Thiophene Ring, as Sodium-Dependent Glucose Cotransporter 2 Inhibitor for the Treatment of Type 2 Diabetes Mellitus. J. Med. Chem. 2010, 53, 6355-6360.
Chemical Properties
Pale yellow oil
Uses
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone manufacturers
- Product
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 95%
- Supply Ability
- 500kg
- Release date
- 2022-09-23
- Product
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 90%
- Supply Ability
- 300kg
- Release date
- 2022-12-27
- Product
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 32384-65-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 500kg
- Release date
- 2023-09-08