ChemicalBook > CAS DataBase List > 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Product Name
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
CAS No.
1030825-20-7
Chemical Name
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Synonyms
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;)-5-(4-fL;Canogliflozin;Canagliflozin-19;CanagliflozinINT;Canagliflozin INT4;2-(5-Bromo-2-methyL;CAGLIFLOZIN IMPURITY C;Canagliflozin Bromo Imp;Canagliflozin Impurity 52
CBNumber
CB72603549
Molecular Formula
C18H14BrFS
Formula Weight
361.27
MOL File
1030825-20-7.mol
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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Property

Melting point:
103 °C
Boiling point:
438.3±40.0 °C(Predicted)
Density 
1.388
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
InChIKey
VLRIERSBZHUCOW-UHFFFAOYSA-N
SMILES
C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5335
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity
>98.0%(GC)
Packaging
200mg
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B5335
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity
>98.0%(GC)
Packaging
1g
Price
$93
Updated
2024/03/01
TRC
Product number
B685970
Product name
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
Packaging
100mg
Price
$135
Updated
2021/12/16
Apolloscientific
Product number
PC448035
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity
98%
Packaging
5g
Price
$107
Updated
2021/12/16
SynQuest Laboratories
Product number
5H66-B-00
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Packaging
5G
Price
$172
Updated
2021/12/16
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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemical Properties,Usage,Production

Uses

2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Synthesis

prepares 2-(4-fluorophenyl) thiophene III:
Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.

Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Suppliers

Americas 1 China 351 Europe 1 India 25 Japan 1 United Kingdom 2 United States 12 Global 393
Inner Mongolia Slanke Pharm-Tech Co., Ltd
Tel
0479-2224266; 15047962002
Email
1304140798@qq.com
Country
China
ProdList
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JOYCHINE BIO-TECH
Tel
18680818008
Email
18680818008@163.com
Country
China
ProdList
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58
Zhejiang Huahai Pharmaceutical Co., Ltd
Tel
0576-85016990 15014006640
Email
1002779550@qq.com
Country
China
ProdList
161
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58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
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China
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5877
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EVERSHINE CHEMICAL CO., LIMITED
Tel
17185714011 17185714011
Email
3506894070@qq.com
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China
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JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
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Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
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66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
14113
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Anhui Lianchuang Biological Medicine Co.,Ltd
Tel
0551-68779238 18056025720
Email
sales3@lcywhx.com
Country
China
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168
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Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11660
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View Lastest Price from 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-16
Shanghai Joiny Pharmaceutical Co.,LTD
Product
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene 1030825-20-7
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg
Release date
2022-09-23
Shaanxi Dideu Medichem Co. Ltd
Product
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-22

1030825-20-7, 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiopheneRelated Search:

5-bromo-2-chloro-4’-ethoxydiphenylmethane (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 4-(5-broMo-2-chlorobenzyl)phenol 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE 5-Bromo-2-methylbenzoic acid D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI) (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 5-Bromo-2-methylbenzoyl chloride 5-Iodo-2-methylbenzoic acid Canagliflozin heMihydrate LIPOPHILIC SEPHADEX 2-(4-Fluorophenyl)-thiophene BCP19353 Canagliflozin 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone

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  • Thiophene, 2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl)-
  • Canagliflozin Intermediate2
  • Canagliflozin INT4
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  • 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene (Canagliflozin Impurity)
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