2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

ChemicalBook > CAS DataBase List > 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Product Name: 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
CAS No.: 1030825-20-7
Chemical Name: 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Synonyms: 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;)-5-(4-fL;Canogliflozin;Canagliflozin-19;CanagliflozinINT;Canagliflozin INT4;2-(5-Bromo-2-methyL;CAGLIFLOZIN IMPURITY C;Canagliflozin Bromo Imp;Canagliflozin Impurity 52
CBNumber: CB72603549
Molecular Formula: C18H14BrFS
Formula Weight: 361.27
MOL File: 1030825-20-7.mol

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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Property

Melting point:: 103 °C
Boiling point:: 438.3±40.0 °C(Predicted)
Density: 1.388
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
form: Solid
color: White to Off-White
InChI: InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
InChIKey: VLRIERSBZHUCOW-UHFFFAOYSA-N
SMILES: C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5335
Product name: 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity: >98.0%(GC)
Packaging: 200mg
Price: $29
Updated: 2024/03/01

TCI Chemical

Product number: B5335
Product name: 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity: >98.0%(GC)
Packaging: 1g
Price: $93
Updated: 2024/03/01

TRC

Product number: B685970
Product name: 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
Packaging: 100mg
Price: $135
Updated: 2021/12/16

Apolloscientific

Product number: PC448035
Product name: 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity: 98%
Packaging: 5g
Price: $107
Updated: 2021/12/16

SynQuest Laboratories

Product number: 5H66-B-00
Product name: 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Packaging: 5G
Price: $172
Updated: 2021/12/16

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2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemical Properties,Usage,Production

Uses

2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Synthesis

prepares 2-(4-fluorophenyl) thiophene III:
Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.

Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene manufacturers

Nanjing Fred Technology Co., Ltd

Product: 2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

Henan Fengda Chemical Co., Ltd

Product: 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene 1030825-20-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500kg
Release date: 2022-09-23

1030825-20-7, 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiopheneRelated Search:

5-bromo-2-chloro-4’-ethoxydiphenylmethane (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 4-(5-broMo-2-chlorobenzyl)phenol 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE 5-Bromo-2-methylbenzoic acid D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI) (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 5-Bromo-2-methylbenzoyl chloride 5-Iodo-2-methylbenzoic acid Canagliflozin heMihydrate LIPOPHILIC SEPHADEX 2-(4-Fluorophenyl)-thiophene BCP19353 Canagliflozin 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene

Thiophene, 2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl)-

Canagliflozin Intermediate2

Canagliflozin INT4

Canogliflozin

Canagliflozin Intermediate II

2-(5-bromo-2-methyl-benzyl-(5-fluorophenyl)thiophene

2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 98%

Canagliflozin Impurity 52

Canagliflozin-19

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7

1030825-20-7 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Canagliflozin Bromo Imp

2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene

)-5-(4-fL

2-(5-Bromo-2-methyL

Canagliflozin Bromo Impurity

2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene (Canagliflozin Impurity)

2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophe...

canagliflozin impurities603

canagliflozin impurities1

Canagliflozin impurity CQ: What is Canagliflozin impurity C Q: What is the CAS Number of Canagliflozin impurity C Q: What is the storage condition of Canagliflozin impurity C

2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thio

CanagliflozinINT

CAGLIFLOZIN IMPURITY C

2- (2-methyl-5-bromobenzyl) -5- (4-fluorobenzene) thiophene

2-(5-Bromo-2- Methylbenzyl)-5-(4-fIuorophenyl) t

1030825-20-7

C18H14BrFS

Pharmaceutical intermediates

1030825-20-7