ChemicalBook > CAS DataBase List > 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene

Product Name
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
CAS No.
1030825-20-7
Chemical Name
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
Synonyms
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene;)-5-(4-fL;Canogliflozin;Canagliflozin-19;CanagliflozinINT;Canagliflozin INT4;2-(5-Bromo-2-methyL;CAGLIFLOZIN IMPURITY C;Canagliflozin Bromo Imp;Kagliflozin impurity 24
CBNumber
CB72603549
Molecular Formula
C18H14BrFS
Formula Weight
361.27
MOL File
1030825-20-7.mol
More
Less

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Property

Melting point:
103 °C
Boiling point:
438.3±40.0 °C(Predicted)
Density 
1.388
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly, Heated), Hexanes (Slightly, Heated)
form 
Solid
color 
White to Off-White
InChI
InChI=1S/C18H14BrFS/c1-12-2-5-15(19)10-14(12)11-17-8-9-18(21-17)13-3-6-16(20)7-4-13/h2-10H,11H2,1H3
InChIKey
VLRIERSBZHUCOW-UHFFFAOYSA-N
SMILES
C1(CC2=CC(Br)=CC=C2C)SC(C2=CC=C(F)C=C2)=CC=1
More
Less

Safety

HS Code 
2934999090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
B5335
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity
>98.0%(GC)
Packaging
200mg
Price
$29
Updated
2024/03/01
TCI Chemical
Product number
B5335
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity
>98.0%(GC)
Packaging
1g
Price
$93
Updated
2024/03/01
TRC
Product number
B685970
Product name
2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
Packaging
100mg
Price
$135
Updated
2021/12/16
Apolloscientific
Product number
PC448035
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Purity
98%
Packaging
5g
Price
$107
Updated
2021/12/16
SynQuest Laboratories
Product number
5H66-B-00
Product name
2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene
Packaging
5G
Price
$172
Updated
2021/12/16
More
Less

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Chemical Properties,Usage,Production

Uses

2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene is an antidiabetic agent that can be used to prepare Canagliflozin (C175190), a sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.

Synthesis

prepares 2-(4-fluorophenyl) thiophene III:
Prepared by Grignard reagent: N 2under protection; magnesium chips (11.7g is added in the 500mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed; 480mmol), THF (15.0mL), drips 2 p-Fluoro bromo benzenes; add the initiation reaction of 2 iodine post-heating; p-Fluoro bromo benzene (70.0g, 400mmol) is dissolved in THF (250mL), after under reflux, drip the THF solution of p-Fluoro bromo benzene; drip Bi Baowen backflow 2h, GC detection feedstock conversion complete.

Linked reaction: N 2under protection; in the 1000mL there-necked flask that thermometer, reflux condensing tube, constant pressure funnel be housed, add 2-bromothiophene (52.2g, 320mmol), under stirring, add two (methyl ethyl diketone) palladium (23.4mg; 0.0320mmol); THF (200mL), is heated to 50 DEG C, the above-mentioned Grignard reagent prepared of rear dropping; drip to finish and be warming up to 60 DEG C; insulation 1h, GC detect to raw material reaction complete, terminate reaction.System is cooled to 30 DEG C, drips dilute hydrochloric acid (2M, 150mL) under ice-water bath, drips complete vigorous stirring 0.5h, removes ice-water bath and make system naturally rise to room temperature, stratification, water layer CH 2cl 2(100mL × 3) extract, merge organic phase saturated sodium-chloride 200mL to wash, rear drying, concentrating under reduced pressure obtain light tan solid, vacuum-drying to constant weight obtains 2-(4-fluorophenyl) thiophene III (57.4g, 312mmol), it is 98.5% that GC detects purity, and yield is 99.1%.
1H NMR(500MHz,CDCl 3)δ7.65～7.54(m,2H),7.33～7.22(m,2H),7.14～7.03(m,3H).Gc-Ms:178.1.

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene Suppliers

Americas 1 China 367 Europe 1 India 24 Japan 1 United Kingdom 2 United States 10 Global 406
GLR Innovations
Tel
+91 9891111994
Email
info@glrgroup.in
Country
India
ProdList
4535
Advantage
58
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Chemicea Pharmaceuticals Pvt Ltd
Tel
--
Fax
--
Email
sales@chemicea.com
Country
India
ProdList
825
Advantage
58
VASIN BIO LIFE SCIENCES PVT LTD
Tel
--
Fax
--
Email
info@vasinbio.com
Country
India
ProdList
2092
Advantage
58
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Aalidhra Pharma Chem Private Ltd
Tel
--
Fax
--
Country
India
ProdList
5
Advantage
58
VIRUPAKSHA ORGANICS LIMITED
Tel
--
Fax
--
Email
accts@virupaksha.com
Country
India
ProdList
26
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Pharmaffiliates Analytics and Synthetics P. Ltd
Tel
--
Fax
--
Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene manufacturers

Nanjing Fred Technology Co., Ltd
Product
2-(5-bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-02
Hebei Weibang Biotechnology Co., Ltd
Product
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-13
Shaanxi Dideu Medichem Co. Ltd
Product
2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-22

1030825-20-7, 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiopheneRelated Search:

5-bromo-2-chloro-4’-ethoxydiphenylmethane (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone 4-(5-broMo-2-chlorobenzyl)phenol 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE 5-Bromo-2-methylbenzoic acid D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI) (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 5-Bromo-2-methylbenzoyl chloride 5-Iodo-2-methylbenzoic acid Canagliflozin heMihydrate LIPOPHILIC SEPHADEX 2-(4-Fluorophenyl)-thiophene BCP19353 Canagliflozin 5-Bromo-2-chlorobenzoic acid (5-broMo-2-chlorophenyl)(2-ethoxyphenyl)Methanone

  • 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
  • 2-[(5-Bromo-2-methylphenyl)methyl]-5-(4-fluorophenyl)thiophene
  • Thiophene, 2-[(5-broMo-2-Methylphenyl)Methyl]-5-(4-fluorophenyl)-
  • Canagliflozin Intermediate2
  • Canagliflozin INT4
  • Canogliflozin
  • Canagliflozin Intermediate II
  • 2-(5-bromo-2-methyl-benzyl-(5-fluorophenyl)thiophene
  • 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl)thiophene 98%
  • Canagliflozin Impurity 52
  • Canagliflozin-19
  • 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene 1030825-20-7
  • 1030825-20-7 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene
  • Canagliflozin Bromo Imp
  • 2-(4-fluorophenyl)-5-[(5-bromo-2-methylphenyl)methyl]thiophene
  • )-5-(4-fL
  • 2-(5-Bromo-2-methyL
  • Canagliflozin Bromo Impurity
  • 2-(5-Bromo-2-methylbenzyl)-5-(4-fluorophenyl]thiophene (Canagliflozin Impurity)
  • 2-((5-bromo-2-methylphenyl)methyl)-5-(4-fluorophenyl)thiophe...
  • canagliflozin impurities603
  • canagliflozin impurities1
  • Canagliflozin impurity CQ: What is Canagliflozin impurity C Q: What is the CAS Number of Canagliflozin impurity C Q: What is the storage condition of Canagliflozin impurity C
  • 2-(5-Bromo-2-methylbenzoyl)-5-(4-fluorophenyl)thio
  • CanagliflozinINT
  • CAGLIFLOZIN IMPURITY C
  • 2- (2-methyl-5-bromobenzyl) -5- (4-fluorobenzene) thiophene
  • 2-(5-Bromo-2- Methylbenzyl)-5-(4-fIuorophenyl) t
  • Kagliflozin impurity 24
  • 1030825-20-7
  • C18H14BrFS
  • Pharmaceutical intermediates
  • 1030825-20-7