5-bromo-4-chlorothieno[2,3-d]pyrimidine
- Product Name
- 5-bromo-4-chlorothieno[2,3-d]pyrimidine
- CAS No.
- 814918-95-1
- Chemical Name
- 5-bromo-4-chlorothieno[2,3-d]pyrimidine
- Synonyms
- 5-BroMo-4-chlorothieno[2,...;5-bromo-4-chlorothieno[2,3-d]pyrimidine;Thieno[2,3-d]pyrimidine, 5-bromo-4-chloro-;5-bromo-4-chlorothienol [2, 3-d] pyrimidine;5-bromo-4-chlorothieno[2,3-d]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB11515803
- Molecular Formula
- C6H2BrClN2S
- Formula Weight
- 249.52
- MOL File
- 814918-95-1.mol
5-bromo-4-chlorothieno[2,3-d]pyrimidine Property
- Boiling point:
- 345.5±37.0 °C(Predicted)
- Density
- 1.955±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.31±0.40(Predicted)
- Appearance
- White to yellow Solid
- CAS DataBase Reference
- 814918-95-1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B684883
- Product name
- 5-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $140
- Updated
- 2021/12/16
- Product number
- FB153032
- Product name
- 5-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB153032
- Product name
- 5-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB153032
- Product name
- 5-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- W8585
- Product name
- 5-Bromo-4-chlorothieno[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $451
- Updated
- 2021/12/16
5-bromo-4-chlorothieno[2,3-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
56844-12-3
814918-95-1
To a solution of diisopropylamine (1.028 mL, 7.21 mmol, 1.8 eq.) dissolved in 10 mL of THF at 0 °C was slowly added n-butyllithium (3.76 mL, 6.01 mmol, 1.5 eq.). After 1 hr of reaction, the resulting LDA solution was transferred to a 35 mL THF solution containing 6-bromo-4-chlorothieno[2,3-d]pyrimidine (1.0 g, 4.01 mmol, 1.0 eq.) at -78 °C and under nitrogen protection. Stirring was continued at -78 °C for 1 h. A mixture consisting of 1.25 mL of water and 5 mL of THF was then slowly added. The reaction mixture was gradually warmed to 0 °C, poured into 60 mL of water and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a yellow solid. The crude product was purified by silica gel column chromatography using a 20% ethyl acetate/hexane gradient elution to give 5-bromo-4-chlorothieno[2,3-d]pyrimidine (tan solid, 671 mg, 67.1% yield). NMR hydrogen spectrum (400 MHz, chloroform-d) δ 8.85 (s, 1H), 7.64 (s, 1H).
References
[1] Patent: WO2012/44993, 2012, A1. Location in patent: Page/Page column 44
[2] Patent: WO2017/46739, 2017, A1. Location in patent: Page/Page column 53
[3] Patent: US2006/89370, 2006, A1. Location in patent: Page/Page column 13-14
[4] Patent: WO2015/136463, 2015, A1. Location in patent: Page/Page column 137
[5] Patent: WO2004/111057, 2004, A1. Location in patent: Page 58-59
5-bromo-4-chlorothieno[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-bromo-4-chlorothieno[2,3-d]pyrimidine manufacturers
- Product
- 5-bromo-4-chlorothieno[2,3-d]pyrimidine 814918-95-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
- Product
- 5-bromo-4-chlorothieno[2,3-d]pyrimidine 814918-95-1
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg, 50kg
- Release date
- 2020-01-09