2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Uses- Product Name
- 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- CAS No.
- 74901-69-2
- Chemical Name
- 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- Synonyms
- 7-dihydrothieno[3;tert-butyl 3-BroMo-6;2,4-Dichloro-6,7-dihydro-thieno[3,2-;2,4-dichloro-6H,7H-thieno[3,2-d]pyrimidine;2,4-Dichloro-6,7-dihyrothieno[3,2-d]pyrimidine;2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine;2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidi...;Thieno[3,2-d]pyrimidine, 2,4-dichloro-6,7-dihydro-;2, 4-dichloro-6, 7-dihydrothiophene [3, 2-d] pyrimidine;2,4-Dichloro-6,7-dihydrothieno[3,2-D]pyrimidine 5,5-dioxide
- CBNumber
- CB31856090
- Molecular Formula
- C6H4Cl2N2S
- Formula Weight
- 207.08
- MOL File
- 74901-69-2.mol
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Property
- Boiling point:
- 329.4±42.0 °C(Predicted)
- Density
- 1.613±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -2.53±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H4Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H2
- InChIKey
- CUVQFHMQHBMFCI-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2SCCC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D435538
- Product name
- 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D435538
- Product name
- 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD142208
- Product name
- 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD142208
- Product name
- 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- Packaging
- 500mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- FD142208
- Product name
- 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
- Packaging
- 1g
- Price
- $237.5
- Updated
- 2021/12/16
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production
Uses
2,4-Dichloro-6,7-dihydrothiophene[3,2-D]pyrimidine is a pyrimidine organic compound that can be used as a pharmaceutical intermediate.
Synthesis
913581-92-7
74901-69-2
General procedure for the synthesis of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (VII) from 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI): 2.4 g (14.1 mmol) of 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI) was suspended in 14 mL of phosphorus oxychloride and added with 4.5 mL (28.2 mmol) of diethylaniline and the mixture was stirred at 80 °C for 22 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water, the precipitate formed was collected by filtration and washed with cold water. The resulting precipitate was dissolved in dichloromethane and the water was removed by a phase separator. The organic phase was concentrated to dryness under reduced pressure to give 2.5 g of the target product VII in 85% yield.
References
[1] Organic Process Research and Development, 2016, vol. 20, # 5, p. 982 - 988
[2] Patent: WO2006/111549, 2006, A1. Location in patent: Page/Page column 61; 59; 65; 68; 69; 72; 74; 76; 84
[3] Patent: US2007/259846, 2007, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2013/26797, 2013, A1. Location in patent: Page/Page column 24-25
[5] Patent: US2013/150341, 2013, A1. Location in patent: Paragraph 0364; 0365; 0366; 0367
2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine manufacturers
- Product
- 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 74901-69-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 74901-69-2
- Price
- US $40.00-1500.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100kg
- Release date
- 2018-08-03