ChemicalBook > CAS DataBase List > 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

Uses

Product Name: 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
CAS No.: 74901-69-2
Chemical Name: 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Synonyms: 7-dihydrothieno[3;tert-butyl 3-BroMo-6;2,4-Dichloro-6,7-dihydro-thieno[3,2-;2,4-dichloro-6H,7H-thieno[3,2-d]pyrimidine;2,4-Dichloro-6,7-dihyrothieno[3,2-d]pyrimidine;2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine;2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidi...;Thieno[3,2-d]pyrimidine, 2,4-dichloro-6,7-dihydro-;2, 4-dichloro-6, 7-dihydrothiophene [3, 2-d] pyrimidine;2,4-Dichloro-6,7-dihydrothieno[3,2-D]pyrimidine 5,5-dioxide
CBNumber: CB31856090
Molecular Formula: C6H4Cl2N2S
Formula Weight: 207.08
MOL File: 74901-69-2.mol

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2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Property

Boiling point:: 329.4±42.0 °C(Predicted)
Density: 1.613±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -2.53±0.20(Predicted)
Appearance: Off-white to light yellow Solid
InChI: InChI=1S/C6H4Cl2N2S/c7-5-4-3(1-2-11-4)9-6(8)10-5/h1-2H2
InChIKey: CUVQFHMQHBMFCI-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(Cl)=C2SCCC2=N1

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Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D435538
Product name: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D435538
Product name: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD142208
Product name: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Packaging: 250mg
Price: $80
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD142208
Product name: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Packaging: 500mg
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD142208
Product name: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine
Packaging: 1g
Price: $237.5
Updated: 2021/12/16

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2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Chemical Properties,Usage,Production

Uses

2,4-Dichloro-6,7-dihydrothiophene[3,2-D]pyrimidine is a pyrimidine organic compound that can be used as a pharmaceutical intermediate.

Synthesis

913581-92-7

74901-69-2

General procedure for the synthesis of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (VII) from 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI): 2.4 g (14.1 mmol) of 6,7-dihydrothieno[3,2-d]pyrimidine-2,4-diol (VI) was suspended in 14 mL of phosphorus oxychloride and added with 4.5 mL (28.2 mmol) of diethylaniline and the mixture was stirred at 80 °C for 22 hours. Upon completion of the reaction, it was cooled to room temperature and the reaction mixture was slowly poured into ice water, the precipitate formed was collected by filtration and washed with cold water. The resulting precipitate was dissolved in dichloromethane and the water was removed by a phase separator. The organic phase was concentrated to dryness under reduced pressure to give 2.5 g of the target product VII in 85% yield.

References

[1] Organic Process Research and Development, 2016, vol. 20, # 5, p. 982 - 988
[2] Patent: WO2006/111549, 2006, A1. Location in patent: Page/Page column 61; 59; 65; 68; 69; 72; 74; 76; 84
[3] Patent: US2007/259846, 2007, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2013/26797, 2013, A1. Location in patent: Page/Page column 24-25
[5] Patent: US2013/150341, 2013, A1. Location in patent: Paragraph 0364; 0365; 0366; 0367

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 74901-69-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Career Henan Chemical Co

Product: 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine 74901-69-2
Price: US $40.00-1500.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-03

74901-69-2, 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidineRelated Search:

4-Phenylthieno[3,2-c]pyridine 4-CHLORO-2,5,6-TRIMETHYLTHIENO[2,3-D]PYRIMIDINE 5-bromo-4-chlorothieno[2,3-d]pyrimidine THIENO[2,3-B]PYRAZINE-6-CARBALDEHYDE 8-ISOQUINOLINE-METHANAMINE, DIHYDRO-CHLORIDE SALT 5-ACETYL-3,4-DIMETHYLTHIENO[2,3-B]THIOPHENE-2-CARBONITRILE 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

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FAVORITES COMPARE 2,4-DICHLORO-6,7-DIHYDROTHIENO[3,2-D]PYRIMIDINE 74901-69-2

2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine ISO 9001：2015 REACH

2, 4-dichloro-6, 7-dihydrothiophene [3, 2-d] pyrimidine

74901-69-2

Heterocycle-Pyrimidine series

CHIRAL CHEMICALS