1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE
- Product Name
- 1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE
- CAS No.
- 111248-89-6
- Chemical Name
- 1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE
- Synonyms
- 1,3-dihydro-2,1-benzothiazole 2,2-dioxide;1,3-dihydrobenzo[c]isothiazole 2,2-dioxide;1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE;2,1-Benzisothiazole, 1,3-dihydro-, 2,2-dioxide;1,3-dihydro-2,1-benzenebenzoisothiazole2,2-dioxy;2,1-Benzisothiazole, 1,3-dihydro-, 2,2-dioxide (9CI, ACI)
- CBNumber
- CB11516350
- Molecular Formula
- C7H7NO2S
- Formula Weight
- 169.2
- MOL File
- 111248-89-6.mol
1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE Property
- Boiling point:
- 311.3±45.0 °C(Predicted)
- Density
- 1.396±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 8.89±0.20(Predicted)
- Appearance
- Light yellow to orange Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D453423
- Product name
- 1,3-Dihydro-2,1-benzothiazole2,2-Dioxide
- Packaging
- 100mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- D453423
- Product name
- 1,3-Dihydro-2,1-benzothiazole2,2-Dioxide
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 5260AQ
- Product name
- 1,3-dihydro-2,1-benzothiazole2,2-dioxide
- Packaging
- 250mg
- Price
- $369.2
- Updated
- 2021/12/16
- Product number
- CM244335
- Product name
- 1,3-Dihydrobenzo[c]isothiazole2,2-dioxide
- Purity
- 95%
- Packaging
- 1g
- Price
- $449
- Updated
- 2021/12/16
- Product number
- CD11351256
- Product name
- 1,3-Dihydrobenzo[c]isothiazole2,2-dioxide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE Chemical Properties,Usage,Production
Synthesis
89665-79-2
111248-89-6
Using (2-chlorophenyl)methanesulfonamide (450 mg, 2.19 mmol) as starting material, tris(dibenzylideneacetone)dipalladium (100 mg, 0.109 mmol), 2-di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl (186 mg, 0.438 mmol), and potassium carbonate (605 mg, 4.38 mmol) were added in a microwave reaction flask, followed by addition of tetrahydrofuran (THF, 8.8 mL) as solvent. The reaction mixture was stirred at 80 °C for 13 hours. Upon completion of the reaction, the reaction was quenched with saturated ammonium chloride solution. Subsequently, the solvent was removed by rotary evaporator and the obtained residue was purified by column chromatography (eluent: cyclohexane/acetone) to give the final 1,3-dihydro-2,1-benzisothiazole-2,2-dioxide as a white solid (296 mg, 80% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ = 7.31-7.26 (m, 1H), 7.26-7.23 (m, 1H), 7.07 (td, J = 7.6, 0.9 Hz, 1H), 6.90 (d, J = 8.0 Hz, 1H), 6.48 (bs, 1H), 4.39 (s, 2H).HPLC analysis (Method C) showed retention time Rt = 1.69 min.
References
[1] Patent: WO2014/63778, 2014, A1. Location in patent: Page/Page column 43
[2] Patent: WO2015/144290, 2015, A1. Location in patent: Page/Page column 87
[3] Patent: US2016/16951, 2016, A1. Location in patent: Paragraph 0245; 0247
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 3, p. 1078 - 1101
[5] Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 1645 - 1649
1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE Preparation Products And Raw materials
Raw materials
Preparation Products
1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE Suppliers
- Tel
- +86 (21) 6435-5022
- Country
- China
- ProdList
- 4267
- Advantage
- 65
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 021-+86-021-38228826 13916602830;
- Fax
- sales@pharmorgsyn.com
- sales@pharmorgsyn.cn
- Country
- China
- ProdList
- 232
- Advantage
- 58
- Tel
- 15902830537
- zhanghao@happysyn.com
- Country
- China
- ProdList
- 3113
- Advantage
- 55
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-20432229
- Fax
- QQ2412110556
- 2412110556@qq.com
- Country
- China
- ProdList
- 6017
- Advantage
- 55
- Tel
- 021-021-021-31663258 13795219287
- Fax
- 021-31663258
- donghuanwen@126.com
- Country
- China
- ProdList
- 8816
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29640
- Advantage
- 60
- Tel
- 025-58859352 19370895928
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15491
- Advantage
- 58
- Tel
- 021-58581007 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
View Lastest Price from 1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE manufacturers
- Product
- 1,3-dihydrobenzo[c]isothiazole 2,2-dioxide 111248-89-6
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 1,3-DIHYDRO-2,1-BENZISOTHIAZOLE 2,2-DIOXIDE 111248-89-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1lg; 2kg; 5kg; 10kg; 100kg
- Release date
- 2019-08-31