3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE

Product Name: 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
CAS No.: 38002-45-8
Chemical Name: 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
Synonyms: (3-BroMoprop-1-yn-1-yl)triMethylsilane;)-1-propyne;(3-Bromo-1-pr;3-Bromo-1-(trimethyL;3-bromoprop-1-ynyl(trimethyl)silane;3-(trimethylsilyl)-propagyl bromide;(3-BROMO-1-PROPYNYL)TRIMETHYLSILANE;3-(TRIMETHYLSILYL)PROPARGYL BROMIDE;3-Bromo-1-(trimethulsilyl)-1-propyne;3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE
CBNumber: CB1151699
Molecular Formula: C6H11BrSi
Formula Weight: 191.14
MOL File: 38002-45-8.mol

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3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE Property

Melting point:: <0°C
Boiling point:: 44-45 °C2 mm Hg(lit.)
Density: 1.17 g/mL at 25 °C(lit.)
refractive index: n20/D 1.483(lit.)
Flash point:: 145 °F
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate (Slightly), Methanol (Slightly)
form: Oil
color: Colourless to Pale Yellow
Specific Gravity: 1.351
Water Solubility: Immiscible with water.
Hydrolytic Sensitivity: 4: no reaction with water under neutral conditions
BRN: 2037650
Stability:: Hygroscopic
InChIKey: GAPRPFRDVCCCHR-UHFFFAOYSA-N
CAS DataBase Reference: 38002-45-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-28-36/37/39
RIDADR: UN 3334
WGK Germany: 3
F: 8-9-19
TSCA: No
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 377775
Product name: 3-Bromo-1-(trimethylsilyl)-1-propyne
Purity: 98%
Packaging: 1g
Price: $36.75
Updated: 2025/07/31

Sigma-Aldrich

Product number: 377775
Product name: 3-Bromo-1-(trimethylsilyl)-1-propyne
Purity: 98%
Packaging: 10g
Price: $306
Updated: 2025/07/31

TCI Chemical

Product number: B1654
Product name: 3-Bromo-1-(trimethylsilyl)-1-propyne
Purity: >97.0%(GC)
Packaging: 1g
Price: $34
Updated: 2025/07/31

TCI Chemical

Product number: B1654
Product name: 3-Bromo-1-(trimethylsilyl)-1-propyne
Purity: >97.0%(GC)
Packaging: 5g
Price: $99
Updated: 2025/07/31

TCI Chemical

Product number: B1654
Product name: 3-Bromo-1-(trimethylsilyl)-1-propyne
Purity: >97.0%(GC)
Packaging: 25g
Price: $300
Updated: 2025/07/31

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3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to pale yellow liquid

Uses

3-Bromo-1-(trimethylsilyl)-1-propyne may be used in the preparation of tetrahydroisoquinoline-3-carboxylic acid derivatives. It may be used as reagent for the alkylation of dianion of β-keto esters at γ-carbon. It may be employed in the preparation of terminal conjugated enynes and allenic alcohols.

General Description

3-Bromo-1-(trimethylsilyl)-1-propyne is reported as a propargylating agent. Selective reaction of 3-bromo-1-(trimethylsilyl)-1-propyne with α-keto ester using indium metal has been studied.

Synthesis

5272-36-6

38002-45-8

The general procedure for the synthesis of 3-bromo-1-trimethylsilyl-1-propyne from trimethylsilylpropargyl alcohol was as follows: To a solution of anhydrous dichloromethane (46.0 mL) containing triphenylphosphine (9.735 g, 37.11 mmol) under nitrogen atmosphere, bromine (5.438 g, 34.03 mmol) was slowly added at 0 °C. After 30 min of reaction, when the color of the solution changed from orange to white, trimethylsilylpropynol (3.960 g, 30.93 mmol) was slowly added. The reaction mixture was continued to be stirred for 1 h, followed by washing with water (3 × 30 mL) and 10% aqueous hydrochloric acid (2 × 20 mL) sequentially. The aqueous layer was extracted with ethyl acetate (3 x 20 mL) and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by column chromatography using hexane as eluent to afford 3-bromo-1-trimethylsilyl-1-propyne in 70% yield (4.125 g, 21.6 mmol).

References

[1] Angewandte Chemie - International Edition, 2014, vol. 53, # 31, p. 8122 - 8126
[2] Chemistry - A European Journal, 2011, vol. 17, # 49, p. 13692 - 13696
[3] Tetrahedron, 1996, vol. 52, # 35, p. 11601 - 11624
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 21, p. 6127 - 6130
[5] Bulletin de la Societe Chimique de France, 1993, vol. 130, # 2, p. 154 - 159

3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE Suppliers

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View Lastest Price from 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE 38002-45-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97.0%
Supply Ability: 10000KGS
Release date: 2025-07-08

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE 38002-45-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-09

Henan Aochuang Chemical Co.,Ltd.

Product: 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE 38002-45-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-16

38002-45-8, 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNERelated Search:

Propargyl bromide 1-TRIMETHYLSILYLMETHANOL 4-PHENYL-3-BUTYN-2-ONE Propyne 1-(Trimethylsilyl)-1-propyne 3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE 3-BROMO-1-(TRIETHYLSILYL)-1-PROPYNE 3-BROMO-1-(TRIISOPROPYLSILYL)-1-PROPYNE 3-BROMO-1-(TERT-BUTYLDIMETHYLSILYL)-1-PROPYNE

3-BROMO-1-TRIMETHYLSILYL-1-PROPYNE 98%

(3-Bromo-1-pr

3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE, 98 %

3-bromo-1-trimethylsilyl-1-propargyne

3-Bromo-1-(trimethulsilyl)-1-propyne

3-(trimethylsilyl)-propagyl bromide

3-bromoprop-1-ynyl(trimethyl)silane

silane, (3-bromo-1-propynyl)trimethyl-

3-BROMO-1-TRIMETHYLSILYL-1-PROPYNE, 97%3-BROMO-1-TRIMETHYLSILYL-1-PROPYNE, 97%3-BROMO-1-TRIMETHYLSILYL-1-PROPYNE, 97%

3-(TRIMETHYLSILYL)PROPARGYL BROMIDE 97+%

3-(Trimethylsilyl)propargyl bromide, 3-Bromo-1-(trimethylsilyl)-1-propyne

(3-BROMO-1-PROPYNYL)TRIMETHYLSILANE

3-BROMO-1-(TRIMETHYLSILYL)-1-PROPYNE

(3-BroMoprop-1-yn-1-yl)triMethylsilane

(3-Bromo-1-propyn-1-yl)trimethyl-silane

3-(TRIMETHYLSILYL)PROPARGYL BROMIDE

3-Bromo-1-(trimethyL

3-Bromo-1-(trimethylsilyl)-1-propyne &gt

Silane, (3-bromo-1-propyn-1-yl)trimethyl-

)-1-propyne

3-Bromo-1-(Trimethylsilyl)-1-Propyne,95%

38002-45-8

BrCH2CCSiCH33

C6H11BrSi

BrCH2C8801CSiCH33

Building Blocks

Alkynes

Organic Building Blocks

Internal

Acetylenes

Si-(C)4 Compounds

Si (Classes of Silicon Compounds)

Silicon Compounds (for Synthesis)

Functionalized Acetylenes

Ethynylsilanes

Acetylenes

Ethynylsilanes

Functionalized Acetylenes

Si (Classes of Silicon Compounds)

Si-(C)4 Compounds

Silicon Compounds (for Synthesis)

Synthetic Organic Chemistry