ChemicalBook > CAS DataBase List > Teneligliptin

Teneligliptin

Product Name
Teneligliptin
CAS No.
760937-92-6
Chemical Name
Teneligliptin
Synonyms
Teliglietin;teneligliptin;Teneligptin WS;Teneligliptin (MP-513);API (Teneligliptin free base);3-[[(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-;[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
CBNumber
CB11518541
Molecular Formula
C22H30N6OS
Formula Weight
426.58
MOL File
760937-92-6.mol
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Teneligliptin Property

Melting point:
>100°C (dec.)
Boiling point:
663.4±55.0 °C(Predicted)
Density 
1.38
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
8.70±0.10(Predicted)
color 
Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
T018295
Product name
Teneligliptin
Packaging
10mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-0882
Product name
Teneligliptin
Purity
99.57%
Packaging
10mg
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-0882
Product name
Teneligliptin
Purity
99.57%
Packaging
50mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0882
Product name
Teneligliptin
Purity
99.57%
Packaging
100mg
Price
$288
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0014166
Product name
TENELIGLIPTIN
Purity
95.00%
Packaging
5MG
Price
$502.54
Updated
2021/12/16
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Teneligliptin Chemical Properties,Usage,Production

Description

Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).

Originator

Mitsubishi Tanabe Pharma (Japan)

Uses

Teneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.

Definition

ChEBI: Teneligliptin is an amino acid amide.

brand name

Tenelia

Teneligliptin Preparation Products And Raw materials

Raw materials

Preparation Products

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Teneligliptin Suppliers

China 149 Germany 1 India 23 United States 9 Global 182
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from Teneligliptin manufacturers

Nanjing Fred Technology Co., Ltd
Product
Teneligliptin 760937-92-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%, Single impurity＜0.1
Supply Ability
1 ton
Release date
2024-01-02
Zhuozhou Wenxi import and Export Co., Ltd
Product
Teneligliptin 760937-92-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Teneligliptin 760937-92-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

760937-92-6, TeneligliptinRelated Search:

N-Methyl-2-pyrrolidone Tribenuron methyl Pyrrolidine PHENYL VALERATE Methyl salicylate Methanol Methyl acrylate 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2R)- VILAZODONE Rivaroxaban Pioglitazone hydrochloride Pyrrole N-Aminoethylpiperazine Polyvinylpyrrolidone Basic Violet 1 Kresoxim-methyl (2S,4R)-Teneligliptin Methylparaben

  • teneligliptin
  • 3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine
  • Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-
  • Teneligptin WS
  • [(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
  • API (Teneligliptin free base)
  • Teliglietin
  • Teneligliptin (MP-513)
  • 3-[[(2S,4R)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine
  • 760937-92-6
  • C22H30N6OS