Description References
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VILAZODONE

Description References
Product Name
VILAZODONE
CAS No.
163521-12-8
Chemical Name
VILAZODONE
Synonyms
CS-108;AK-Con;All Clear;Vilozodone;VILAZODONE;EMD 515259;Clear Eyes;Vilazodonei;Vilazodone-d6;Vilazodone HCL
CBNumber
CB31011682
Molecular Formula
C26H27N5O2
Formula Weight
441.52
MOL File
163521-12-8.mol
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VILAZODONE Property

Melting point:
203-205°C
Boiling point:
745.1±60.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly)), Methanol (Slightly)
pka
15.98±0.30(Predicted)
form 
Solid
color 
Pale Yellow to Beige
Stability:
Very Hygroscopic
CAS DataBase Reference
163521-12-8
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Safety

Hazardous Substances Data
163521-12-8(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
V265000
Product name
Vilazodone
Packaging
250mg
Price
$295
Updated
2021/12/16
ChemScene
Product number
CS-0550
Product name
Vilazodone
Purity
99.91%
Packaging
50mg
Price
$396
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
D34392
Product name
Vilazodone-d8HCl
Packaging
1mg
Price
$675
Updated
2021/12/16
Matrix Scientific
Product number
094760
Product name
5-(4-(4-(5-Cyano-1H-indol-3-yl)butyl)piperazin-1-yl)benzofuran-2-carboxamide
Purity
95+%
Packaging
250mg
Price
$681
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008118
Product name
VILAZODONE
Purity
95.00%
Packaging
10MG
Price
$697.2
Updated
2021/12/16
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VILAZODONE Chemical Properties,Usage,Production

Description

Vilazodone is a kind of serotonergic antidepressant developed by Merck KGaA Company. It is a novel compound with high affinity and selectivity for the 5-hydroxytrptamine (5-HT) transporter and 5-HT (1A) receptors. It is indicated for the treatment of major depressive disorder (MDD). It is can be used as an alternative drugs for other kind of antidepressant classes drugs that can’t be tolerated by patients. As a selective serotonin reuptake inhibitor, vilazodone can prevent the serotonin from re-entering into cell bodies, therefore making it remain longer inside the synapse. Moreover, it has a high selectivity for the serotonin-1A receptor, taking effect as a partial agonist that can simulate the production of serotonin. These effects result in increased serotonin in the synaptic cleft. This effect is related to the antidepressant effect of vilazodone in vivo.

References

https://www.drugbank.ca/drugs/DB06684
https://en.wikipedia.org/wiki/Vilazodone
http://www.rxlist.com/viibryd-drug/indications-dosage.htm

Description

In January 2011, the U.S. FDA approved vilazodone for the treatment of major depressive disorder (MDD). Vilazodone is a novel antidepressant agent that combines potent serotonin reuptake inhibition (IC50=0.2 nM) with high affinity for 5-HT1A receptors (IC50=0.5 nM)and partial 5-HT1A receptor agonist functional activity. Vilazodone has good selectivity over other monoamine receptors and is efficacious in preclinical models of depression in rats and mice. Vilazodone is an indolylbutylpiperazine derivative that has been prepared by coupling of an indolylbutyl chloride or tosylate with 5-(piperazin-1-yl)benzofuran-2- carboxamide or the corresponding ester. The cyanoindole portion of vilazodone is important for conferring high affinity for both the serotonin transporter and the 5-HT1A receptor. Para-substitution on the phenyl group attached to the piperidine moiety reduces affinity for dopamine receptors, while the carboxamide group provides improved pharmacokinetic properties.

Chemical Properties

Light Yellow Solid

Originator

Merck KGaA (Germany)

Uses

It is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression.

Uses

Labelled analogue of Vilazodone

Uses

An inhibitor of ST and activator of SR-1A

Definition

ChEBI: A 1-benzofuran that is 5-(piperazin-1-yl}-1-benzofuran-2-carboxamide having a (5-cyanoindol-3-yl)butyl group attached at position N-4 on the piperazine ring. Used for the treatment of major depressive disorder.

brand name

Viibryd

VILAZODONE Preparation Products And Raw materials

Raw materials

Preparation Products

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VILAZODONE Suppliers

Chemvon Biotechnology Co., Ltd
Tel
021-50790412
Fax
+86-21-50790419
Email
info@chemvon.com
Country
China
ProdList
371
Advantage
57
Nanjing Jiusi Pharmaceutical Technology Development Co., Ltd.
Tel
123
Email
jiusiyiyao2020@126.com
Country
China
ProdList
89
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Synches Co., Ltd.
Tel
021-53292253
Fax
021-53292253
Email
biz@synches.com
Country
China
ProdList
200
Advantage
64
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4001
Advantage
55
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14059
Advantage
65
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View Lastest Price from VILAZODONE manufacturers

Guangzhou Sunton Biotechnology Co., Ltd.
Product
Vilazodone 163521-12-8
Price
US $48.00-40.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
2tons
Release date
2021-06-17
Dideu Industries Group Limited
Product
VILAZODONE 163521-12-8
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-26
Zhuozhou Wenxi import and Export Co., Ltd
Product
vilazodone 163521-12-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

163521-12-8, VILAZODONERelated Search:


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