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Vilazodone Hydrochloride

Product Name
Vilazodone Hydrochloride
CAS No.
163521-08-2
Chemical Name
Vilazodone Hydrochloride
Synonyms
CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;4-Methylenedioxyphenol;Vilazodone hydrochloride;Vilazodone HCl (EMD 68843;Vera trazodone hydrochloride;Vilazodone hydrochloride API;Vilazodone hydrochloride salt
CBNumber
CB72521214
Molecular Formula
C26H28ClN5O2
Formula Weight
477.98582
MOL File
163521-08-2.mol
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Vilazodone Hydrochloride Property

Melting point:
279°C(lit.)
Flash point:
9℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
color 
white to beige
Stability:
Hygroscopic
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Safety

Hazard Codes 
F,T
Risk Statements 
11-23/24/25-39/23/24/25
Safety Statements 
7-16-36/37-45
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1098
Product name
Vilazodone hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$70.8
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1098
Product name
Vilazodone hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$289
Updated
2024/03/01
TCI Chemical
Product number
V0149
Product name
Vilazodone Hydrochloride
Purity
>98.0%(HPLC)
Packaging
50mg
Price
$236
Updated
2024/03/01
TCI Chemical
Product number
V0149
Product name
Vilazodone Hydrochloride
Purity
>98.0%(HPLC)
Packaging
200mg
Price
$657
Updated
2024/03/01
Cayman Chemical
Product number
21547
Product name
Vilazodone (hydrochloride)
Purity
≥95%
Packaging
50mg
Price
$93
Updated
2024/03/01
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Vilazodone Hydrochloride Chemical Properties,Usage,Production

Description

Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.

Uses

Vilazodone Hydrochloride, is the salt form of Vilazodone (V265000), which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.

Definition

ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.

Clinical Use

Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.

Synthesis

Vilazodone hydrochloride is a combined serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist marketed under the trade name Viibryd.202 Viibryd was developed by Merck KGaA (Germany) and approved for the treatment of depression by the U.S. FDA on January 21st, 2011. Vilazodone has been shown to be well-tolerated at higher dosage levels, specifically by not causing significant weight gain or decreased sexual desire or function, which are improvements over existing antidepressant treatments.

storage

Store at -20°C

Vilazodone Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Vilazodone Hydrochloride Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8843
Advantage
52
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2873
Advantage
58
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
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View Lastest Price from Vilazodone Hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Vilazodone Hydrochloride 163521-08-2
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-01-09
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Vilazodone Hydrochloride 163521-08-2
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-09
Hebei Best Biological Technology Co., Ltd
Product
Vilazodone Hydrochloride 163521-08-2
Price
US $200.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000t/month
Release date
2022-11-30

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