Vilazodone Hydrochloride

ChemicalBook > CAS DataBase List > Vilazodone Hydrochloride

Vilazodone Hydrochloride

Product Name: Vilazodone Hydrochloride
CAS No.: 163521-08-2
Chemical Name: Vilazodone Hydrochloride
Synonyms: CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;4-Methylenedioxyphenol;Vilazodone hydrochloride;Vilazodone HCl (EMD 68843;Vera trazodone hydrochloride;Vilazodone hydrochloride API;Vilazodone hydrochloride salt
CBNumber: CB72521214
Molecular Formula: C26H28ClN5O2
Formula Weight: 477.98582
MOL File: 163521-08-2.mol

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Vilazodone Hydrochloride Property

Melting point:: 279°C(lit.)
Flash point:: 9℃
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO: soluble20mg/mL, clear
form: powder
color: white to beige
Stability:: Hygroscopic

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Safety

Hazard Codes: F,T
Risk Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45
RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1098
Product name: Vilazodone hydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $70.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1098
Product name: Vilazodone hydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $289
Updated: 2024/03/01

TCI Chemical

Product number: V0149
Product name: Vilazodone Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 50mg
Price: $236
Updated: 2024/03/01

TCI Chemical

Product number: V0149
Product name: Vilazodone Hydrochloride
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $657
Updated: 2024/03/01

Cayman Chemical

Product number: 21547
Product name: Vilazodone (hydrochloride)
Purity: ≥95%
Packaging: 50mg
Price: $93
Updated: 2024/03/01

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Vilazodone Hydrochloride Chemical Properties,Usage,Production

Description

Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT_1A (IC₅₀s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.

Uses

Vilazodone Hydrochloride, is the salt form of Vilazodone (V265000), which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.

Definition

ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.

Clinical Use

Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.

Synthesis

Vilazodone hydrochloride is a combined serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist marketed under the trade name Viibryd.202 Viibryd was developed by Merck KGaA (Germany) and approved for the treatment of depression by the U.S. FDA on January 21st, 2011. Vilazodone has been shown to be well-tolerated at higher dosage levels, specifically by not causing significant weight gain or decreased sexual desire or function, which are improvements over existing antidepressant treatments.

storage

Store at -20°C

Vilazodone Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vilazodone Hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Vilazodone Hydrochloride 163521-08-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-09

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Vilazodone Hydrochloride 163521-08-2
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-10-09

Hebei Best Biological Technology Co., Ltd

Product: Vilazodone Hydrochloride 163521-08-2
Price: US $200.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 1000t/month
Release date: 2022-11-30

163521-08-2, Vilazodone HydrochlorideRelated Search:

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Vilazodone hydrochloride

5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2-carboxaMide hydrochloride、Vilazodone hydrochloride

EMD 68843

SB 659746A

CS-796

5-[4-[4-(5-Cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-2-benzofurancarboxamide hydrochloride

VILAZODONE; EMD 68843; SB 659746A

Vilazodone hydrochloride solution

Vilazodone HCl, >=98%

Vilazodone hydrochloride, 98%, a 5-HT1A receptor partial agonist

Vera trazodone hydrochloride

Vilazodone hydrochloride(Vilazodone HCl)

Vilazodone hydrochloride API

2-Benzofurancarboxamide, 5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]-1-piperazinyl]-, hydrochloride (1:1)

5-[4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl]-1-benzofuran-2-carboxamide hydrochloride

Vilazodone Hydrochloride USP/EP/BP

Vilazodone hydrochloride salt

Vilazodone HCl (EMD 68843

5-[4-[4-(5-Cyanoindol-3-yl)butyl]piperazin-1-yl]benzofuran-2...

Vilazodone HydrochlorideQ: What is Vilazodone Hydrochloride Q: What is the CAS Number of Vilazodone Hydrochloride Q: What is the storage condition of Vilazodone Hydrochloride Q: What are the applications of Vilazodone Hydrochloride

4-Methylenedioxyphenol

2H8]-Vilazodone hydrochloride salt

163521-08-2

C26H27N5O2HCl

C26H28ClN5O2

C26H27N5O2ClH

API

Inhibitors