Vilazodone Hydrochloride
- Product Name
- Vilazodone Hydrochloride
- CAS No.
- 163521-08-2
- Chemical Name
- Vilazodone Hydrochloride
- Synonyms
- CS-796;EMD 68843;SB 659746A;Vilazodone HCl, >=98%;4-Methylenedioxyphenol;Vilazodone hydrochloride;Vilazodone HCl (EMD 68843;Vera trazodone hydrochloride;Vilazodone hydrochloride API;Vilazodone hydrochloride salt
- CBNumber
- CB72521214
- Molecular Formula
- C26H28ClN5O2
- Formula Weight
- 477.98582
- MOL File
- 163521-08-2.mol
Vilazodone Hydrochloride Property
- Melting point:
- 279°C(lit.)
- Flash point:
- 9℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- color
- white to beige
- Stability:
- Hygroscopic
Safety
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25
- Safety Statements
- 7-16-36/37-45
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 3
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1098
- Product name
- Vilazodone hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 10mg
- Price
- $70.8
- Updated
- 2024/03/01
- Product number
- SML1098
- Product name
- Vilazodone hydrochloride
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $289
- Updated
- 2024/03/01
- Product number
- V0149
- Product name
- Vilazodone Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 50mg
- Price
- $236
- Updated
- 2024/03/01
- Product number
- V0149
- Product name
- Vilazodone Hydrochloride
- Purity
- >98.0%(HPLC)
- Packaging
- 200mg
- Price
- $657
- Updated
- 2024/03/01
- Product number
- 21547
- Product name
- Vilazodone (hydrochloride)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $93
- Updated
- 2024/03/01
Vilazodone Hydrochloride Chemical Properties,Usage,Production
Description
Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a partial agonist of the serotonin (5-HT) receptor subtype 5-HT1A (IC50s = 0.2 and 0.5 nM, respectively). It increases extracellular 5-HT in the rat ventral hippocampus and frontal cortex when administered intraperitoneally at doses of 1 and 3 mg/kg. Vilazodone (1 mg/kg, i.p.) decreases immobility in the forced swim test in both rats and mice. Formulations containing vilazodone have been used in the treatment of depression.
Uses
Vilazodone Hydrochloride, is the salt form of Vilazodone (V265000), which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. Antidepressant.
Definition
ChEBI: A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.
Clinical Use
Althoughseveral synthetic approaches have beenreported,a process-scale synthesis of vilazodone consists of the union of an indole-containing butyl tosylate 284 with a benzofuranyl piperazine whose synthesis is described in the scheme below. Piperazine 280 arises from a Buchwald coupling of commercially available benzofuranyl bromide 279 with piperazine through the use of a unique catalyst system employing the DavePhos ligand. This single coupling step, which has been executed on multigram scale in 70% yield,210 circumvented the need for any protecting group chemistry for either the primary amide within 279 or the piperazine amine functionality. For the preparation of the key indole subunit, Friedel-Crafts acylation of commercially available 5-cyanoindole (281) proceeded in good yield at the 3-position of the indole with 4-chlorobutanoyl chloride in 82% yield. Treatment of the resulting chloroketone with sodium borohydride in refluxing isopropanol converted 282 to the corresponding terminal alcohol 283. Tosylation of this alcohol was followed by displacement with piperazine 280 to give vilazodone hydrochloride (XXV) after acidification.
Synthesis
Vilazodone hydrochloride is a combined serotonin reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist marketed under the trade name Viibryd.202 Viibryd was developed by Merck KGaA (Germany) and approved for the treatment of depression by the U.S. FDA on January 21st, 2011. Vilazodone has been shown to be well-tolerated at higher dosage levels, specifically by not causing significant weight gain or decreased sexual desire or function, which are improvements over existing antidepressant treatments.
storage
Store at -20°C
Vilazodone Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Vilazodone Hydrochloride Suppliers
- Tel
- --
- Fax
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- druginfo@tevausa.com
- Country
- Israel
- ProdList
- 130
- Advantage
- 58
- Tel
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- megan.carroll@tevapharm.com
- Country
- Israel
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View Lastest Price from Vilazodone Hydrochloride manufacturers
- Product
- Vilazodone Hydrochloride 163521-08-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-01-09
- Product
- Vilazodone Hydrochloride 163521-08-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-10-09
- Product
- Vilazodone Hydrochloride 163521-08-2
- Price
- US $200.00/g
- Min. Order
- 10g
- Purity
- 99%
- Supply Ability
- 1000t/month
- Release date
- 2022-11-30