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Anidulafungin

Product Name
Anidulafungin
CAS No.
166663-25-8
Chemical Name
Anidulafungin
Synonyms
Eraxis;Ecalta;CS-2272;LY 303366;nidulafungin;AN(Local GMP);Anidulafungin;LY 303366, Eraxis;Anidulafungin-d11;Anidulafungin(LY303366)
CBNumber
CB71120054
Molecular Formula
C58H73N7O17
Formula Weight
1140.24
MOL File
166663-25-8.mol
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Anidulafungin Property

Boiling point:
1477.0±65.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,2-8°C
pka
9.86±0.26(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20753
Product name
Anidulafungin
Purity
≥98%
Packaging
1mg
Price
$189
Updated
2021/03/22
Cayman Chemical
Product number
20753
Product name
Anidulafungin
Purity
≥98%
Packaging
5mg
Price
$898
Updated
2021/03/22
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Anidulafungin Chemical Properties,Usage,Production

Description

Anidulafungin, a semi-synthetic derivative of echinocandin B, has been developed and launched as an intravenous treatment for serious fungal infections, such as candidemia, Candida-derived peritonitis, intra-abdominal abscesses, and esophageal candidiasis. As a non-competitive inhibitor of 1,3-b-D-glucan synthase, which is responsible for the formation of glucan polymers, anidulafungin interferes with the cell wall synthesis of most pathogenic fungi. This mode of action is characteristic of the echinocandin class of antifungals. While the first member of this class, cilofungin, was withdrawn due to toxicity associated with the formulation vehicle, anidulafungin follows the successful introduction of caspofungin and micafungin. Compared to the other echinocandins, anidulafungin appears to be more potent (MIC90 ofr0.25 mg/mL for C.albicans, 0.5 mg/mL for C.glabrata, 1 mg/mL for C. krusel and C.tropicalis, 2mg/mL for C.lusitaniae, and 2 mg/mL for Aspergillus spp) and is devoid of significant drug interactions since it is neither an inhibitor nor substrate of the cytochrome P450 isoenzymes. The emergence of the echinocandins circumvents the concern regarding the rising resistance to the azole and amphotericin B antifungals; no cross-resistance is expected because the echinocandins work at the cell wall rather than the cell membrane.

Originator

Eli Lilly (US)

Uses

Anidulafungin is a semi-synthetic cyclic lipopeptide belonging to the echinocandin class that was reported in 1995 and commercially developed by Eli Lilly. Anidulafungin inhibits the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi and is extensively referenced in the literature with over 400 citations.

Uses

nucleoside reverse transcriptase inhibitor (NRTI) for HIV treatment in adults

Definition

ChEBI: A semisynthetic echinocandin anti-fungal drug. It is active against Aspergillus and Candida species and is used for the treatment of invasive candidiasis.

brand name

Eraxis (Vicuron).

Antimicrobial activity

It is active against Aspergillus spp., Candida spp. and the cyst stage of Pneumocystis jirovecii. Resistance has not yet been reported.

Pharmaceutical Applications

A semisynthetic lipopeptide derived from a fermentation product of Aspergillus nidulans. Formulated for intravenous infusion.

Pharmacokinetics

Cmax 100 mg 1-h infusion: c. 9 mg/L end infusion
Plasma half-life: 18–27 h
Volume of distribution: 0.6 L/kg
Plasma protein binding: 84%
Blood concentrations increase in proportion to dosage. The steady state is achieved on the first day after a loading dose (twice the daily maintenance dose).
Distribution
Levels in the CSF are negligible.
Metabolism and excretion
Unlike caspofungin and micafungin, anidulafungin is not metabolized by the liver, but undergoes slow non-enzymatic degradation in the blood to a peptide breakdown product which is enzymatically degraded and excreted in the feces and bile. About 30% of a dose is eliminated in the feces, of which less than 10% is unchanged drug. Less than 1% of a dose is excreted in the urine. No dosage adjustment is required in patients with hepatic or renal impairment. Anidulafungin is not cleared by hemodialysis.

Clinical Use

Candidemia and certain invasive forms of candidosis
Esophageal candidosis

Side effects

Occasional histamine-mediated infusion-related reactions, injection site reactions and transient abnormalities of liver enzymes have been reported.

Anidulafungin Preparation Products And Raw materials

Raw materials

Preparation Products

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Anidulafungin Suppliers

Guangzhou Zhiya Chemdrugs Co.,Ltd
Tel
Fax
QQ:2869377561
Email
sculk28@163.com
Country
China
ProdList
670
Advantage
55
Taizhou KEDE Chemical Co., Ltd
Tel
0576-84613060-
Fax
0576-84613060
Email
sales@kedechemical.com;sales01@kedechemical.com;
Country
China
ProdList
292
Advantage
60
Yunfei Pharmaceutical(Shenzhen) Co., Ltd.
Tel
0755-61160828-
Fax
0755-61160828
Email
hulixiu@yunfeipharma.com;
Country
China
ProdList
267
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
;
Fax
18140514863
Email
bd@ruiweier.cn;lq@ruiweier.cn
Country
China
ProdList
1013
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5948
Advantage
61
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
1938
Advantage
70
Nanjing Chemlin Chemical Co., Ltd
Tel
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
20001
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
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View Lastest Price from Anidulafungin manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
Anidulafungin 166663-25-8
Price
US $10.00/KG
Min. Order
500g
Purity
99%
Supply Ability
2000MT/Month
Release date
2021-07-07
Wuhan Boye Science And Technology Development Co., Ltd.
Product
?Anidulafungin 166663-25-8
Price
US $0.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
100KG
Release date
2021-04-15
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Anidulafungin 166663-25-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000kg/month
Release date
2021-07-27

166663-25-8, AnidulafunginRelated Search:


  • Anidulafungin
  • Echinocandin B, 1-(4R,5R)-4,5-dihydroxy-N2-4-(pentyloxy)1,1:4,1-terphenyl-4-ylcarbonyl-L-ornithine-
  • Anidulafungin(LY303366)
  • Ecalta
  • Eraxis
  • LY 303366
  • LY 303366, Eraxis
  • 1-[(4R,5R)-4,5-dihydroxy-N2-[[4''-(pentyloxy)[1,1'',1''-terphenyl]-4-yl]carbonyl]-L-ornithine]-echinocandin B
  • Anidulafungin-d11
  • AN(Local GMP)
  • nidulafungin
  • CS-2272
  • Anidulafungin fandachem
  • Anidulafungin USP/EP/BP
  • 166663-25-8
  • 66663-25-8
  • C58H73N7O17
  • Inhibitors
  • Antifungals
  • API