Trifluoperazine dihydrochloride
- Product Name
- Trifluoperazine dihydrochloride
- CAS No.
- 440-17-5
- Chemical Name
- Trifluoperazine dihydrochloride
- Synonyms
- Urinox;skf5019;Stelazin;eskazine;STELAZINE;Eskazinyl;Ai3-50137;Calmazine;tryptazine;Einecs 207-123-0
- CBNumber
- CB1274387
- Molecular Formula
- C21H26Cl2F3N3S
- Formula Weight
- 480.42
- MOL File
- 440-17-5.mol
Trifluoperazine dihydrochloride Property
- Melting point:
- 243 °C (dec.)(lit.)
- Flash point:
- 9℃
- storage temp.
- -20°C
- solubility
- ethanol: soluble5mg/mL
- pka
- pK1 3.9, pK2 8.1(at 25℃)
- form
- powder
- color
- white to off-white
- λmax
- 312nm(MeOH)(lit.)
- Merck
- 14,9680
- BRN
- 3820024
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 440-17-5(CAS DataBase Reference)
- EPA Substance Registry System
- 10H-Phenothiazine, 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-, dihydrochloride (440-17-5)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
H341Suspected of causing genetic defects
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- T-117
- Product name
- Trifluoperazine dihydrochloride solution
- Purity
- 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $172
- Updated
- 2024/03/01
- Product number
- 1685000
- Product name
- Trifluoperazine hydrochloride
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200mg
- Price
- $261.6
- Updated
- 2024/03/01
- Product number
- T2849
- Product name
- Trifluoperazine Dihydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $100
- Updated
- 2024/03/01
- Product number
- T2849
- Product name
- Trifluoperazine Dihydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $347
- Updated
- 2024/03/01
- Product number
- 15068
- Product name
- Trifluoperazine (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
Trifluoperazine dihydrochloride Chemical Properties,Usage,Production
Description
Trifluoperazine (TFP) is a phenothiazine compound with anti-
Chemical Properties
Cream Fine Powder
Originator
Stelazine,SKF,US,1958
Uses
Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.
Uses
Antipsychotic
Manufacturing Process
A mixture of 17.2 grams of 2-trifluoromethylphenothiazine, 3.1 grams of sodamide and 14 grams of 1-(3'-chloropropyl)-4-methylpiperazine in 200 ml of xylene is heated at reflux for 2 hours. The salts are extracted into 150 ml of water. The xylene layer is then extracted with several portions of dilute hydrochloric acid. The acid extracts are combined and neutralized with ammonium hydroxide solution. The product, 10-[3'-(4''-methyl-1''- piperazinyl)-propyl]-2-trifluoromethylphenothiazine, is taken into benzene and purified by vacuum distillation, BP 202° to 210°C at 0.6 mm.
Therapeutic Function
Tranquilizer
General Description
Trifluoperazinehydrochloride, 10-[3-(4-Methyl-1-piperazinyl)propyl-[2-(trifluoromethyl)phenothiazine dihydrochloride (Stelazine).The absorption of trifluoperazine is erratic and variable andit is widely distributed into tissues. The excretion of trifluoperazineoccurs 50% via kidneys and the other 50% isthrough enterohepatic circulation. The metabolism and druginteractions of trifluoperazine are the same as with the otherphenothiazines. Trifluoperazine does not show any specificdrug interactions. Trifluoperazine is indicated for the managementof schizophrenia and short-term treatment ofnonpsychotic anxiety.
Biochem/physiol Actions
Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.
Safety Profile
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F-, NOx, SOx, and HCl. See also FLUORIDES.
Purification Methods
Recrystallise the salt from absolute EtOH, filter the crystals, dry them in vacuo and store them in tightly stoppered bottles because it is hygroscopic. It is soluble in H2O but insoluble in *C6H6, Et2O and alkaline aqueous solution. It has UV at 258 and 307.5nm (log 4.50 and 3.50) in EtOH (neutral species). [Craig max et al. J Org Chem 22 709 1957.] It is a calmodulin inhibitor [Levene & Weiss J Parmacol Exptl Ther 208 454 1978] and is a psychotropic agent [Fowler Arzneim.-Forsch 27 866 1977]. [Beilstein 27 III/IV 1353.]
Trifluoperazine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Trifluoperazine dihydrochloride manufacturers
- Product
- Trifluoperazine dihydrochloride 440-17-5
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-16
- Product
- Trifluoperazine dihydrochloride 440-17-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-23
- Product
- Trifluoperazine dihydrochloride 440-17-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11